Analytical and Bioanalytical Chemistry

, Volume 372, Issue 2, pp 301–304

Miniature surface-plasmon resonance immunosensors – rapid and repetitive procedure

  • Masayasu Suzuki
  • Fumihiko Ozawa
  • Wakako Sugimoto
  • Shuji Aso
Special Issue Paper

DOI: 10.1007/s00216-001-1209-3

Cite this article as:
Suzuki, M., Ozawa, F., Sugimoto, W. et al. Anal Bioanal Chem (2002) 372: 301. doi:10.1007/s00216-001-1209-3

Abstract.

Miniaturized immunosensors based on surface-plasmon resonance (SPR) have been developed by using the sensor recently developed by Texas Instruments. By using this sensor for human immunoglobulin G (IgG) rapid and repetitive measurements could be performed by alternate injection of sample and glycine-HCl buffer. A sensor for human serum albumin (HSA) could also be developed similarly. One difficulty in immunosensor development is dissociation of the strongly bound antigen–antibody complex. A "regenerable" immunosensor has also been developed for this reason.

Immunosensor SPR Miniaturization Human IgG Biosensor 

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Masayasu Suzuki
    • 1
  • Fumihiko Ozawa
    • 1
  • Wakako Sugimoto
    • 2
  • Shuji Aso
    • 2
  1. 1.Department of Electric and Electronic Engineering, Toyama University,3190 Gofuku, Toyama, Toyama 930–8555, Japan
  2. 2.Department of Biochemical Engineering and Science, Kyushu Institute of Technology, 680–4 Kawazu, Iizuka, Fukuoka 820–8502, Japan

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