Theoretical Chemistry Accounts

, 131:1286 | Cite as

Enzyme dynamics and catalysis in the mechanism of DNA polymerase

Regular Article


This contribution contains the commentaries of the three authors about two papers in this issue of TCA that present alternative views of the role of conformational changes in the specificity of enzyme DNA polymerase β. Concepts such as dynamical effects, the induced fit model or the importance of sampling in modeling of enzymatic reactions are briefly revised within the context of the debate established in the two previous papers.


Enzyme dynamics Enzymatic catalysis Dynamical effects DNA polymerase 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Centre for Computational Chemistry, School of ChemistryUniversity of BristolBristolUK
  2. 2.Department of Chemistry and Quantum Theory ProjectUniversity of FloridaGainesvilleUSA
  3. 3.Departamento de Química FísicaUniversidad de ValenciaBurjasotSpain

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