Theoretical Chemistry Accounts

, Volume 125, Issue 3, pp 329–334

Raman spectroscopy study of breast disease

  • Marcelo Moreno
  • Leandro Raniero
  • Emília Ângelo Loschiavo Arisawa
  • Ana Maria do Espírito Santo
  • Edson Aparecido Pereira dos Santos
  • Renata Andrade Bitar
  • Airton Abrahão Martin
Regular Article

DOI: 10.1007/s00214-009-0698-6

Cite this article as:
Moreno, M., Raniero, L., Arisawa, E.Â.L. et al. Theor Chem Acc (2010) 125: 329. doi:10.1007/s00214-009-0698-6

Abstract

The aim of this study was to evaluate the vibrational modes of malignant and benign breast tissues with the following diagnosis: fibroadenoma, invasive ductal carcinoma, ductal carcinoma in situ, and fibrocystic condition. Quadratic discriminate analysis, a multivariate statistical method of analysis, showed 98.5% separation between normal and altered tissue. Significant changes were observed at the lower Raman shift for altered tissue. For a better understanding of the spectral differences, a biochemical interpretation was also performed in terms of the reduction and oxidation processes in the cell environment which could be associated with an inflammatory reaction.

Keywords

Raman spectroscopy Breast cancer Principal component analysis Biochemical analysis Linear discriminant analysis Quadratic correlation analysis 

Abbreviations

BC

Breast cancer

RS

Raman spectroscopy

FBC

Fibrocystic breast conditions

FD

Fibroadenoma

DCIS

Ductal carcinoma in situ

IDC

Invasive ductal carcinoma

PCA

Principal component analysis

LDA

Linear discriminant analysis

QDA

Quadratic correlation analysis

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Marcelo Moreno
    • 1
    • 2
  • Leandro Raniero
    • 1
  • Emília Ângelo Loschiavo Arisawa
    • 1
  • Ana Maria do Espírito Santo
    • 1
  • Edson Aparecido Pereira dos Santos
    • 1
  • Renata Andrade Bitar
    • 1
  • Airton Abrahão Martin
    • 1
  1. 1.Laboratory of Biomedical Vibrational Spectroscopy, Institute of Research and Development, IP&DUniversidade do Vale do Paraíba, UniVapSão José dos CamposBrazil
  2. 2.Medical SchoolUniversidade Comunitária Regional de Chapecó, UnochapecóChapecóBrazil

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