Psychopharmacology

, Volume 159, Issue 3, pp 284–293 | Cite as

Blockade or stimulation of D1 dopamine receptors attenuates cue reinstatement of extinguished cocaine-seeking behavior in rats

  • Andrea T. Alleweireldt
  • Suzanne M. Weber
  • Kenneth F. Kirschner
  • Breanna L. Bullock
  • Janet L. Neisewander
Original Investigation

Abstract.

Rationale: D1 dopamine receptor antagonists and agonists attenuate cocaine reinstatement of cocaine-seeking behavior (i.e., responding in the absence of cocaine reinforcement). Objectives: The present study investigated the effects of a D1 antagonist (SCH-23390), partial agonist (SKF-38393), and full agonist (SKF-81297) on reinstatement of cocaine-seeking behavior elicited by presentation of cocaine-paired cues. Methods: Rats that had been trained to self-administer cocaine with a light/tone stimulus complex paired with each infusion underwent extinction across days. After responding diminished, rats were given response-contingent access to the cocaine-paired stimulus complex. The effects of SCH-23390 (0–10.0 µg/kg), SKF-38393 (0–3.0 mg/kg), and SKF-81297 (0–3.0 mg/kg) on cue reinstatement of cocaine-seeking behavior were examined. The ability of the two D1 agonists to independently reinstate cocaine-seeking behavior and the effects of SKF-81297 on cocaine reinstatement were also examined. To investigate the possibility of behavioral interference, the effects of SKF-38393 and SKF-81297 on grooming and stereotypy were assessed. Results: SCH-23390 and SKF-81297, but not SKF-38393, attenuated cue reinstatement. However, while SKF-81297 dose-dependently increased response latency, SCH-23390 did not. SKF-81297 also independently reinstated responding at the two lowest doses tested while SKF-38393 had no effect. Furthermore, SKF-81297 decreased cocaine reinstatement and increased response latency only at the highest dose. Finally, stereotypy was observed at all doses of SKF-81297 that also decreased responding, although the patterns of changes in these behaviors did not completely correspond. Conclusions: While the antagonist and full agonist produced similar effects on cocaine-seeking behavior, only the agonist increased response latency, suggesting that different processes mediate the effects of these drugs.

Relapse SCH-23390 SKF-38393 SKF-81297 Conditioned reinforcement Stereotyped behavior 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Andrea T. Alleweireldt
    • 1
  • Suzanne M. Weber
    • 1
  • Kenneth F. Kirschner
    • 1
  • Breanna L. Bullock
    • 1
  • Janet L. Neisewander
    • 1
  1. 1.Department of Psychology, Arizona State University, Box 871104, Tempe, AZ 85287-1104, USAUSA

Personalised recommendations