The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects
- Cite this article as:
- Stough, C., Lloyd, J., Clarke, J. et al. Psychopharmacology (2001) 156: 481. doi:10.1007/s002130100815
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Rationale: Extracts of Bacopa monniera have been reported to exert cognitive enhancing effects in animals. However, the effects on human cognition are inconclusive. Objective: The current study examined the chronic effects of an extract of B. monniera (Keenmind) on cognitive function in healthy human subjects. Methods: The study was a double-blind placebo-controlled independent-group design in which subjects were randomly allocated to one of two treatment conditions, B. monniera (300 mg) or placebo. Neuropsychological testing was conducted pre-(baseline) and at 5 and 12 weeks post drug administration. Results: B. monniera significantly improved speed of visual information processing measured by the IT task, learning rate and memory consolidation measured by the AVLT (P<0.05), and state anxiety (P<0.001) compared to placebo, with maximal effects evident after 12 weeks. Conclusions: These findings suggest that B. monniera may improve higher order cognitive processes that are critically dependent on the input of information from our environment such as learning and memory.