, Volume 143, Issue 3, pp 315–317

Anandamide induces overeating: mediation by central cannabinoid (CB1) receptors

  • Claire M. Williams
  • T. C. Kirkham
Rapid Communication

DOI: 10.1007/s002130050953

Cite this article as:
Williams, C. & Kirkham, T. Psychopharmacology (1999) 143: 315. doi:10.1007/s002130050953


Rationale: Central cannabinoid systems have been implicated in appetite regulation by the respective hyperphagic actions of exogenous cannabinoids, such as Δ9-THC, and hypophagic effects of selective cannabinoid receptor antagonists. Objective: This study examined whether an endogenous cannabinoid, anandamide, could induce overeating, via a specific action at central (CB1) cannabinoid receptors. Methods: Pre-satiated male rats (n=18), received subcutaneous injections of anandamide (0.5, 1.0, 5.0, 10.0 mg/kg) before 3-h, nocturnal food intake tests. In a second series of intake tests (n=8), anandamide injection (1.0 mg/kg) was preceded by injection of the specific CB1 receptor antagonist, SR141716 (0.1, 0.5, 1.0 mg/kg SC). Results: All doses of anandamide induced significant overeating, with 1.0 mg/kg being most potent. Additionally, hyperphagia induced by 1.0 mg/kg anandamide was dose-dependently attenuated by SR141716 pretreatment. Conclusion: This first demonstration of anandamide-induced, CB1-mediated, overeating provides important evidence for the involvement of a central cannabinoid system in the normal control of eating.

Key words SR141716 Hyperphagia Rat Pre-feed Eating Appetite 

Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • Claire M. Williams
    • 1
  • T. C. Kirkham
    • 1
  1. 1.Department of Psychology, University of Reading, Whiteknights, PO Box 238, Reading RG6 6AL, UK, e-mail:, Fax: +44-1189-316-715GB

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