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Psychopharmacology

, Volume 142, Issue 2, pp 132–138 | Cite as

Short-term treatment with citicoline (CDP-choline) attenuates some measures of craving in cocaine-dependent subjects: a preliminary report

  • Perry F. Renshaw
  • Sarah Daniels
  • Leslie H. Lundahl
  • Veronica Rogers
  • S. E. Lukas
ORIGINAL INVESTIGATION

Abstract

The administration of cytidine-5′-diphosphate choline (CDP-choline, citicoline) to animals increases the rate of membrane phospholipid synthesis and elevates brain dopamine levels. Because cocaine dependence has been associated with increases in brain phospholipid precursors, as well as depletion of dopamine within the central nervous system, the present outpatient study was conducted to assess the safety of citicoline (500 mg bid) and to determine if short-term treatment alters mood states and cocaine craving in subjects with a history of cocaine dependence. In addition, measures of drug craving and mood states after presentation of cocaine-related cues were collected on two occasions: before and after 14 days of double-blind treatment with either citicoline or placebo. Subjects did not experience any side effects and citicoline treatment was associated with decreases in self-reported mood states associated with cocaine craving. These preliminary data are encouraging and suggest that citicoline warrants further study as a promising potential treatment for cocaine abuse and dependence that is devoid of side effects.

Key words Cocaine Craving Cytidine CDP-choline Human Medication Drug dependent Citicoline 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • Perry F. Renshaw
    • 1
  • Sarah Daniels
    • 2
  • Leslie H. Lundahl
    • 2
  • Veronica Rogers
    • 2
  • S. E. Lukas
    • 2
  1. 1.Brain Imaging Center, McLean Hospital/Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USAUS
  2. 2.Behavioral Psychopharmacology Research Laboratory, McLean Hospital/Harvard Medical School, East House III, 115 Mill Street, Belmont, MA 02478, USA e-mail: lukas@mclean.org, Fax: +1-617-855-3711US

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