Psychopharmacology

, Volume 138, Issue 1, pp 9–15

Acute tryptophan depletion attenuates the prolactin response to d-fenfluramine challenge in healthy human subjects

  • E. F. Coccaro
  • Richard J. Kavoussi
  • Thomas B. Cooper
  • Richard Hauger
ORIGINAL INVESTIGATION

DOI: 10.1007/s002130050639

Cite this article as:
Coccaro, E., Kavoussi, R., Cooper, T. et al. Psychopharmacology (1998) 138: 9. doi:10.1007/s002130050639

Abstract

Prolactin responses to d-fenfluramine (d-FEN) Challenge (0.5 mg/kg PO) were examined after pretreatment with and without acute tryptophan depletion (ATD) in six physically healthy male volunteers. Compared to pretreatment with SHAM-ATD, ATD pretreatment attenuated the PRL response to d-FEN Challenge in all subjects. These data suggest that PRL responses to d-FEN challenge reflect to a substantial degree the activity of newly synthesized 5-HT.

Key wordsd-Fenfluramine Tryptophan Prolactin Human 

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • E. F. Coccaro
    • 1
  • Richard J. Kavoussi
    • 1
  • Thomas B. Cooper
    • 2
  • Richard Hauger
    • 3
  1. 1.Clinical Neuroscience Research Unit, Department of Psychiatry, MCP Hahnemann School of Medicine, 3200 Henry Avenue, Philadelphia, PA 19129, USA Fax: +1-215-842-4321US
  2. 2.Analytical Psychopharmacology Laboratory, Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York, USAUS
  3. 3.Neuroendocrine Research Laboratory, Department of Psychiatry, University of California, San Diego, California, USAUS

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