Psychopharmacology

, Volume 137, Issue 4, pp 362–368 | Cite as

The effects of smoking on acoustic prepulse inhibition in healthy men and women

  • V. Della Casa
  • I. Höfer
  • I. Weiner
  • J. Feldon
ORIGINAL INVESTIGATION

Abstract

Acoustic prepulse inhibition (PPI) refers to the reduction of the startle reflex to an intense stimulus if it is preceded by a weak stimulus. Nicotine and smoking have been reported to enhance PPI in rats and in healthy men, respectively. We studied the influence of smoking on PPI in healthy men and women, comparing non-smokers, deprived smokers, and smokers smoking during the test session after deprivation or after ad libitum smoking. Smoking during the session enhanced PPI, without affecting startle reaction or habituation over time. In addition, the effect of smoking on PPI was gender dependent. In men, ad libitum smoking enhanced PPI compared with non-smokers, while, in women, deprivation reduced PPI and smoking restored PPI to the level of non-smokers.

Key words Startle Prepulse inhibition Gating Human Smoking Nicotine Gender 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • V. Della Casa
    • 1
  • I. Höfer
    • 1
  • I. Weiner
    • 2
  • J. Feldon
    • 1
  1. 1.Behavioral Biology and Functional Toxicology, Institute of Toxicology, Swiss Federal Institute of Technology Zürich, Schorenstrasse 16, CH-8603 Schwerzenbach, Switzerland e-mail: feldon@toxi.biol.ethz.ch, Fax: + 41-1-825-7417CH
  2. 2.Department of Psychology, Tel Aviv University, Ramat-Aviv, 69978 Tel Aviv, IsraelIL

Personalised recommendations