Psychopharmacology

, Volume 136, Issue 4, pp 335–341 | Cite as

Isradipine prevents global and regional cocaine-induced changes in brain blood flow: a preliminary study

  • B. Johnson
  • Bruce Barron
  • Bing Fang
  • L. Lamki
  • Louis Wagner
  • Lynda Wells
  • Paul Kenny
  • Dennis Overton
  • Sukhindar Dhother
  • David Abramson
  • Richard Chen
  • Larry Kramer
ORIGINAL INVESTIGATION

Abstract

The L-type calcium channel antagonist, isradipine, reduces brain ischemia in animal models of ischemic stroke. These effects of isradipine appear more pronounced in dopamine (DA) rich brain regions. These same DA-rich brain regions have also been shown to be the areas most affected by cocaine-induced ischemic changes. Using a novel quantified approach to single photon emission computerized tomography, we demonstrated that isradipine pre-treatment prevented cocaine-induced ischemic changes, especially in these DA-rich brain regions. This is the first demonstration that any medication, including isradipine, can prevent the ischemic effects of cocaine on brain blood flow. Isradipine may, therefore, be a useful therapeutic agent for the prevention of brain ischemia in cocaine addicts.

Key words Cocaine Brain blood flow Quantitative SPECT Ischemia Isradipine Stroke Calcium channel antagonist Human 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • B. Johnson
    • 1
  • Bruce Barron
    • 2
  • Bing Fang
    • 2
  • L. Lamki
    • 2
  • Louis Wagner
    • 2
  • Lynda Wells
    • 3
  • Paul Kenny
    • 3
  • Dennis Overton
    • 3
  • Sukhindar Dhother
    • 3
  • David Abramson
    • 3
  • Richard Chen
    • 1
  • Larry Kramer
    • 4
  1. 1.Clinical Laboratory and Experimental Alcohol Research Center, University of Texas – Health Science Center at Houston, 1300 Moursund St, Houston, TX 77030, USAUS
  2. 2.University of Texas – Health Science Center at Houston, Hermann Hospital, 6411 Fannin St, Houston, TX 77030, USAUS
  3. 3.University of Texas – Health Science Center at Houston, Department of Anesthesiology, 6431 Fannin St, Houston, TX 77030, USAUS
  4. 4.University of Texas – Health Science Center at Houston, Department of Radiology, 6431 Fannin St, Houston, TX 77030, USAUS

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