, Volume 134, Issue 3, pp 303–308

Precipitating factors in spontaneous recurrence of methamphetamine psychosis

  • K. Yui
  • Takeo Ishiguro
  • Kimihiko Goto
  • Shigenori Ikemoto

DOI: 10.1007/s002130050453

Cite this article as:
Yui, K., Ishiguro, T., Goto, K. et al. Psychopharmacology (1997) 134: 303. doi:10.1007/s002130050453


This paper examines noradrenergic hyperactivity in response to stress in the development of spontaneous recurrences of methamphetamine (MAP) psychosis, a phenomenon known as flashbacks, in studies of psychedelic drug use. We studied predictors of flashbacks in 36 subjects with flashbacks, along with 80 subjects with a histroy of MAP psychosis who did not experience flashbacks. Plasma monoamine metabolite levels were assayed in 26 of the 36 subjects with flashbacks, 16 of the 80 subjects without flashbacks, nine subjects with persistent MAP psychosis, and 28 normal controls. None of the 28 controls became psychotic. A square root transformation was applied to all monoaminergic values, resulting in data nearly normally distributed. The subjects with flashbacks had been exposed to stressful events or threatening paranoid-hallucinatory states or both during previos MAP use. Most flashbacks occurred under conditions that provoked a mild fear of other people. Plasma norepinephrine levels were markedly increased during flashbacks. Thus, stressful experiences together with MAP use may have induced noradrenergic hyperreactivity to a mild stress, which in turn may elicit memories of MAP psychosis associated with stressful experiences. A mild fear of other people precipitated the flashbacks, including markedly increased noradrenergic activity. The results of this study suggest that noradrenergic hyperreactivity to a mild stress is a precipitating factor in spontaneous recurrences of MAP psychosis.

Key words Methamphetamine psychosis Flashbacks Precipitating factor Stressful experience Noradrenergic hyperactivity 

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • K. Yui
    • 1
  • Takeo Ishiguro
    • 2
  • Kimihiko Goto
    • 3
  • Shigenori Ikemoto
    • 4
  1. 1.Medical Care Section, Urawa Juvenile Classification Home, Ministry of Justice, Takasago 3-16-34-31, Urawa 336, Japan Fax (+81)48/836-1372JP
  2. 2.Department of Psychiatry, Jichi Medical School, Tochigi 329-04, JapanJP
  3. 3.Yamazaki College, Shibuya 151, Tokyo, JapanJP
  4. 4.Department of Legal Medicine and Human Genetics, Jichi Medical School, Tochigi 329-04, JapanJP

Personalised recommendations