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Psychopharmacology

, Volume 133, Issue 3, pp 300–304 | Cite as

Self-administration in rats allowed unlimited access to nicotine

  • James D. Valentine
  • Jonathan S. Hokanson
  • Shannon G. Matta
  • B. M. Sharp
RAPID COMMUNICATION

Abstract

 The purpose of the present study was to develop an animal model of nicotine self-administration that more closely approximates the conditions of human nicotine use than do existing models. In most nicotine self-administration models, rats acquire self-administration during brief daily sessions in which rapid injections of a relatively high dose of the drug, 0.03 mg/kg, serve as the reinforcer. The present study examined nicotine self-administration in rats that acquired the behavior while having virtually unlimited access to injections of a relatively low dose of the drug; the rats did not have any prior operant training or shaping. Under these conditions, rats readily acquire nicotine self-administration at doses at least as low as 0.00375 mg/kg per injection, and they self-administer throughout the active portion of their light cycle. The daily nicotine intake of rats, which ranged from 0.18 to 1.38 mg/kg per day, appears to be comparable to that of human smokers.

Key words Nicotine Self-administration Intravenous Dose-response Nicotine intake Unlimited access Rats 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • James D. Valentine
    • 1
  • Jonathan S. Hokanson
    • 1
  • Shannon G. Matta
    • 1
  • B. M. Sharp
    • 1
  1. 1.Endocrine-Neuroscience Research Laboratories, Minneapolis Medical Foundation, 914 S. Eighth Street, Minneapolis, MN 55404, USAUS

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