Psychopharmacology

, Volume 132, Issue 4, pp 396–401

Improvement of acute exacerbations of schizophrenia with amisulpride: a comparison with haloperidol

  • H. J. Möller
  • P. Boyer
  • O. Fleurot
  • W. Rein
  • PROD-ASLP Study Group
ORIGINAL INVESTIGATION

DOI: 10.1007/s002130050361

Cite this article as:
Möller, H., Boyer, P., Fleurot, O. et al. Psychopharmacology (1997) 132: 396. doi:10.1007/s002130050361

Abstract

Amisulpride is a substituted benzamide with high selectivity for dopaminergic D2 and D3 receptors. This study compared 800 mg/day amisulpride and 20 mg/day haloperidol in patients with acute exacerbations of schizophrenia. This multicenter, double-blind trial involved 191 patients allocated, after a 1 to 7-day wash-out period, to amisulpride (n = 95) or haloperidol (n = 96) for 6 weeks. Improvement of mean BPRS total score was 48% for amisulpride and 38% for haloperidol (NS), whereas improvement in the Negative PANSS subscale was greater in the amisulpride group (37%) compared to haloperidol (24%) (P = 0.038). CGI scores showed a higher number of responders in the amisulpride (62%) than in the haloperidol group (44%) (P = 0.014). More extrapyramidal symptoms measured with the Simpson-Angus scale were provoked in the haloperidol group (P = 0.0009). Amisulpride is at least as effective as haloperidol in the treatment of acute exacerbations of schizophrenia, and is more effective in the treatment of negative symptoms whilst causing less parkinsonism.

Key words Amisulpride Atypical antipsychotic Schizophrenia Haloperidol Productive symptoms Secondary negative symptoms 

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • H. J. Möller
    • 1
  • P. Boyer
    • 2
  • O. Fleurot
    • 3
  • W. Rein
    • 4
  • PROD-ASLP Study Group
  1. 1.Department of Psychiatry, University of Munich Medical School, Nussbaumstrasse 7, D-80336 Munich, GermanyDE
  2. 2.Centre Hospitalier Sainte-Anne, 100 rue de la Santé, F-75014 Paris, FranceFR
  3. 3.Synthélabo Recherche, 31 avenue Vaillant-Couturier, F-92225 Bagneux Cedex, FranceFR
  4. 4.Synthélabo Groupe, 22 avenue Galilée, BP 82, F-92352 Le Plessis-Robinson Cedex, FranceFR

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