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Psychopharmacology

, Volume 131, Issue 1, pp 79–85 | Cite as

The attenuation of morphine-conditioned place preference following chronic mild stress is reversed by a CCKB receptor antagonist

  • Olga Valverde
  • Claire Smadja
  • Bernard P. Roques
  • R. Maldonado
ORIGINAL INVESTIGATION

Abstract

Chronic exposure to mild unpredictable stress has been found to abolish the acquisition of preference for a distinctive environment paired with morphine, whereas morphine induced conditioning place preference in non-stressed rats. Chronic treatment for 21 days with the tricyclic antidepressant imipramine reversed the motivational effects produced by chronic mild stress, and animals showed a place preference for the morphine-paired compartment. When the CCKB receptor antagonist PD-134,308 was co-administered with morphine in stressed animals during the conditioning period, the preference for the morphine-paired compartment was also re-established. The CCKB receptor antagonist given alone did not induce rewarding effects in this paradigm. These findings indicate that the administration of a CCKB receptor antagonist reversed the effects of chronic mild stress on opiate rewarding properties.

Key words Conditioned place preference Chronic unpredictable mild stress Reward CCKB receptor antagonist Depression Stress Morphine Imipramine PD-134 308 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Olga Valverde
    • 1
  • Claire Smadja
    • 1
  • Bernard P. Roques
    • 1
  • R. Maldonado
    • 1
  1. 1.Département de Pharmacologie Moléculaire et Structurale, U266 INSERM, URA D 1500 CNRS, Université René Descartes, URF des Sciences Pharmaceutiques et Biologiques, 4, Avenue de l’Observatoire, F-75270 Paris Cedex 06, FranceFR

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