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Psychopharmacology

, Volume 130, Issue 4, pp 404–406 | Cite as

Substitution of the selective serotonin reuptake inhibitors fluoxetine and paroxetine for the discriminative stimulus effects of ethanol in rats

  • S. Maurel
  • Rudy Schreiber
  • Jean De Vry
RAPID COMMUNICATION

Abstract

 Rats trained to discriminate ethanol (EtOH, 1 g/kg IP) from saline in a two-lever procedure completely generalized to the selective serotonin reuptake inhibitors (SSRIs) fluoxetine and paroxetine. Substitution of fluoxetine was completely blocked by the selective 5-HT2A receptor antagonist MDL 100,907 and not affected by the selective 5-HT1A receptor antagonist WAY-100635. It is suggested that the previously reported effectiveness of SSRIs in reducing EtOH consumption could be based on similarities in discriminative stimulus effects of SSRIs and EtOH. Stimulation of 5-HT2A receptors may underlie these stimulus similarities and contribute to the EtOH intake-reducing effects of SSRIs.

Key words 5-HT receptor subtypes Alcoholism Drug discrimination MDL 100 907 WAY-100635 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • S. Maurel
    • 1
  • Rudy Schreiber
    • 1
  • Jean De Vry
    • 1
  1. 1.Institute for Neurobiology, Troponwerke GmbH & Co. KG, Neurather Ring 1, D-51063 Köln, GermanyDE

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