The ability of THA treatment to increase cortical alpha waves is related to apolipoprotein E genotype of Alzheimer disease patients
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In a previous study, we reported that Alzheimer disease (AD) patients with an apolipoprotein E (APOE) ɛ4 allele (+ APOE4) show more severe loss of nucleus basalis (NB) cholinergic cells than patients without ɛ4 alleles (− APOE4). The present study investigates the effects of a single oral administration of THA 25 or 50 mg on cortical spectral EEG activity in + (five APOE4/4, six APOE4/3) and − APOE4 (eight APOE3/3) AD patients. THA 25 mg had no significant effect on EEG activity in any AD patients. However, THA 50 mg increased alpha activity and alpha/theta ratio in − APOE4 patients. In contrast, THA 50 mg had no effect on EEG activity in + APOE4 patients. This result tentatively suggests that in AD patients APOE genotype may affect the response of cortical electrical arousal to cholinergic therapy that enhances the efficacy of presynaptic NB axons.
Key wordsTHA EEG slowing Apolipoprotein E Alzheimer disease
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- Björklund M, Jäkälä P, Schmidt B, Riekkinen M, Koivisto E, Riekkinen P Jr (1996) An indirect Cholinesterase inhibitor, metrifonate, increases neocortical EEG arousal in rats. NeuroReport (in press)Google Scholar
- Davis KL, Thal LJ, Gamzu ER, Davis SC, Woolfson RF, Gracon SI, Drachman DA, Schneider LS, Whitehouse P, Hoover TM, Morris JC, Kawas CH, Knopman DS, Earl NL, Kumar V, Doody R, Tacrine Collaborative Study Group (1992) A double-blind, placebo-controlled multicenter study of tacrine for Alzheimer’s disease. N Engl J Med 327:1253–1259PubMedGoogle Scholar
- Helkala E-L, Koivisto K, Hänninen T, Vanhanen M, Kervinen K, Kuusisto J, Mykkänen L, Kesäniemi YA, Laakso M, Riekkinen P Sr (1996) Memory functions in human subjects with different apolipoprotein E phenotypes during a 3-year population-based follow-up study. Neurosci Lett 204:177–180PubMedCrossRefGoogle Scholar