Sumatriptan decreases food intake and increases plasma growth hormone in healthy women
- Cite this article as:
- Boeles, S., Williams, C., Campling, G. et al. Psychopharmacology (1997) 129: 179. doi:10.1007/s002130050178
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We studied the effect of the 5-HT1B/1D receptor agonist sumatriptan (6 mg SC) on plasma growth hormone and prolactin and food intake in 15 healthy female subjects using a double-blind, placebo-controlled, cross-over design. Sumatriptan significantly elevated plasma growth hormone but did not alter plasma prolactin. Sumatriptan also significantly lowered total food intake in a buffet meal, particularly decreasing the intake of fat. Our results indicate that 5-HT1B/1D receptors may be involved in the regulation of food intake in humans. In addition, while activation of 5-HT1B/1D receptors stimulates growth hormone release in both men and women, sumatriptan lowers plasma prolactin only in men, suggesting sex differences in the 5-HT regulation of prolactin release.