Psychopharmacology

, Volume 128, Issue 2, pp 130–138 | Cite as

Characterization of tobacco withdrawal symptoms: transdermal nicotine reduces hunger and weight gain

  • D. E. Jorenby
  • Dorothy K. Hatsukami
  • Stevens S. Smith
  • Michael C. Fiore
  • Sharon Allen
  • Joni Jensen
  • Timothy B. Baker
ORIGINAL INVESTIGATION

Abstract

The accurate assessment of both tobacco withdrawal and the impact of the nicotine patch on withdrawal may be compromised by attrition of subjects, or by subjects smoking during withdrawal. To reduce these occurrences, 211 participants were provided with intensive cessation counseling while trying to quit smoking with either nicotine (21 mg) or placebo transdermal patches. Subject attrition was low, with 80.5% of participants continuing through the 5-week study period. Abstinence rates were also high over this period (75% and 61% in active and placebo groups, respectively). In this multisite, double-blind trial, withdrawal severity was assessed using a nine-item daily self-report questionnaire, and abstinence was confirmed via CO monitoring. Abrupt smoking cessation increased multiple tobacco withdrawal symptoms/signs including craving for cigarettes, irritability, anxiety, appetite, sleep disruption, difficulty concentrating, restlessness, depression, and impatience. Treatment with transdermal nicotine reduced craving for cigarettes, anxiety, irritability, and appetite, as well as weight gain (1.85 versus 2.88 kg mean gain over 4 weeks in active and placebo groups, respectively).

Key words Nicotine Tobacco withdrawal Transdermal nicotine patch 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • D. E. Jorenby
    • 1
  • Dorothy K. Hatsukami
    • 2
  • Stevens S. Smith
    • 1
  • Michael C. Fiore
    • 1
  • Sharon Allen
    • 2
  • Joni Jensen
    • 2
  • Timothy B. Baker
    • 1
  1. 1.Center For Tobacco Research and Intervention, University of Wisconsin, Madison, WI 53706, USAUS
  2. 2.Tobacco Research Laboratory, Department of Psychiatry, University of Minnesota, MN 55455, USAUS

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