Psychopharmacology

, Volume 128, Issue 1, pp 31–38 | Cite as

Reduction of guinea pig pup isolation calls by anxiolytic and antidepressant drugs

  • H. E. Molewijk
  • K. Hartog
  • A. M. van der Poel
  • J. Mos
  • B. Olivier
ORIGINAL INVESTIGATION

Abstract

 Guinea pigs possess central 5-HT1D receptors similar to humans but different from rats and mice. In order to study the role of this receptor on animal behaviour, it may be of interest to develop a paradigm measuring affective states in the guinea pig. Therefore we assessed the effects of a variety of psychotropic drugs on guinea pig pup isolation calls. Anxiolytic compounds such as the benzodiazepine receptor agonists diazepam and alprazolam, the full 5-HT1A receptor agonists 8-OH-DPAT and flesinoxan, and alcohol reduced isolation calling by the guinea pig pup. Moreover, mixed antidepressant/anxiolytic compounds like the 5-HT uptake inhibitors fluvoxamine and clomipramine or the MAO-inhibitor clorgyline as well as the antidepressant NA uptake inhibitors desipramine and maprotiline suppressed vocalizations. The 5-HT1D/1A receptor agonist 5-CT was also very effective in reducing separation calls. Remarkably, the partial 5-HT1A receptor agonists buspirone and BMY 7378 did not affect calling. The neuroleptic haloperidol, the psychostimulant d-amphetamine, the putative anxiogenics DMCM and m-CPP and the putative anxiolytics ondansetron and CI-988 had no effect on isolation calls of guinea pig pups. We propose this paradigm could be helpful to assess behavioural effects of anxiolytic and antidepressant drugs in a species different from rat or mouse, and in which the effects of 5-HT1D receptor ligands may possibly be established.

Key words Distress vocalizations Guinea pig pup Anxiolytics Antidepressants Benzodiazepines 5-HT1A receptor ligands 5-HT uptake inhibitors NA uptake inhibitor 5-CT 5-HT1D receptor Alcohol 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • H. E. Molewijk
    • 1
  • K. Hartog
    • 1
  • A. M. van der Poel
    • 1
  • J. Mos
    • 1
  • B. Olivier
    • 1
  1. 1.CNS Pharmacology, Solvay Duphar B.V., P.O. Box 900, 1380 DA Weesp, The NetherlandsNL

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