Psychopharmacology

, Volume 148, Issue 4, pp 404–411 | Cite as

The loudness dependency of the auditory evoked N1/P2-component as a predictor of the acute SSRI response in depression

  • J. Gallinat
  • R. Bottlender
  • G. Juckel
  • A. Munke-Puchner
  • G. Stotz
  • H. -J. Kuss
  • P. Mavrogiorgou
  • U. Hegerl
Original Investigation

Abstract 

Rationale: A serotonergic dysfunction is supposed to play a pathogenetic role in depression, but there is a considerable number of non-responders in the acute treatment of depression with serotonergic agents like SSRI. Thus, an indicator of central serotonergic activity could lead to a more specific pharmacological treatment of depression. In animal and human data there is a growing amount of evidence that a strong loudness dependency of late auditory evoked potentials (LDAEP) is an indicator of low serotonergic activity and vice versa. Objective: In 29 depressive inpatients (DSM-III-R diagnosis 296.x in 28 patients, 300.4 in one patient), the hypothesis was tested that a strong LDAEP prior to treatment can predict a better clinical outcome under SSRI treatment over 4 weeks. Results: Patients with a strong pre-treatment LDAEP had a significantly greater decrease of depressive symptoms (Hamilton Scale for Depression) after 4 weeks than patients with a flat LDAEP. Significantly more responders fell into the group with a high LDAEP. Contrary to what might be expected, a second recording in a subsample of 19 patients after 4 weeks of treatment failed to show changes in the LDAEP. Conclusion: Our finding confirms the hypothesis that a strong LDAEP, indicating a low serotonergic activity, is related to a favorable response to acute SSRI treatment in depression. The LDAEP is a promising tool for the prediction of response to serotonin agonists in depression and it seems to be of clinical importance.

Key words Auditory evoked potentials Serotonin Depression Response prediction Augmenting/reducing 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • J. Gallinat
    • 1
  • R. Bottlender
    • 2
  • G. Juckel
    • 2
  • A. Munke-Puchner
    • 2
  • G. Stotz
    • 2
  • H. -J. Kuss
    • 2
  • P. Mavrogiorgou
    • 2
  • U. Hegerl
    • 2
  1. 1.Department of Psychiatry, Laboratory of Clinical Psychophysiology, Free University Berlin, Eschenallee 3, 14050 Berlin, Germany e-mail: gallinat@zedat.fu-berlin.de, Fax: +49-30-306-85-122DE
  2. 2.Department of Psychiatry, Laboratory of Clinical Neurophysiology, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich, GermanyDE

Personalised recommendations