, Volume 148, Issue 4, pp 344–349

Ipsapirone challenge in aggressive men shows an inverse correlation between 5-HT1A receptor function and aggression

  • A. J. Cleare
  • A. J. Bond
Original Investigation


Previous studies have suggested that 5-HT1A receptor function is linked to aggression. We studied 12 healthy men selected to have high trait levels of aggression. They filled in various self-rating measures of aggression, and underwent a double blind, crossover challenge with ipsapirone (20 mg orally) and a placebo. On both occasions, we measured the endocrine (ACTH, cortisol, growth hormone and prolactin), hypothermic and bodily symptom responses every 30 min for 180 min. We found that subjects with blunted neuroendocrine responses to the ipsapirone challenge had significantly higher self-ratings of aggression on a number of measures. The same relationship held using the bodily symptom response to ipsapirone: blunted responses were associated with higher ratings of aggression. We conclude that impaired 5-HT1A receptor function is associated with increased aggressiveness.

Key words Neuroendocrine Prolactin Cortisol ACTH Growth hormone Serotonin Irritability Anger 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • A. J. Cleare
    • 1
  • A. J. Bond
    • 2
  1. 1.Department of Psychological Medicine, Institute of Psychiatry and Guy’s King’s and St Thomas’ School of Medicine, 103 Denmark Hill, London SE5 8AZ, UK e-mail:, Fax: +44-171-740-5129GB
  2. 2.Department of Psychiatry, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UKGB

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