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Psychopharmacology

, Volume 150, Issue 1, pp 45–51 | Cite as

Acute administration of amitriptyline and mianserin increases dopamine release in the rat nucleus accumbens: possible involvement of serotonin2C receptors

  • Vincenzo Di Matteo
  • Michele Di Mascio
  • Giuseppe Di Giovanni
  • Ennio Esposito
Original Investigation

Abstract.

Previous studies of conventional tricyclic and non-tricyclic antidepressants have suggested that a number of these drugs display considerable pharmacological activity at 5-HT2C receptors in the brain. There is evidence that 5-HT2C receptors are involved in the control of the activity of the central dopaminergic system. Therefore, the effects of amitriptyline (5 mg/kg and 10 mg/kg i.p.) and of the atypical antidepressant mianserin (2.5 mg/kg and 5 mg/kg i.p.) were studied on the extracellular concentration of dopamine (DA) in the nucleus accumbens of chloral hydrate-anesthetized rats, using intracerebral microdialysis. Amitriptyline and mianserin significantly increased DA release (+31.1±7.9% and +33.6±4.3%, respectively) at the higher doses. In addition, lower doses of mianserin (2.5 mg/kg i.p.) and amitriptyline (5 mg/kg i.p.) blocked the inhibitory action of RO 60-0175 (1 mg/kg i.p.), a selective 5-HT2C receptor agonist, on DA release. The effect of RO 60-0175 (1 mg/kg i.p.) was completely blocked by SB 242084 (2.5 mg/kg i.p.), a selective and powerful 5-HT2C receptor antagonist. Taken together, these data indicate that amitriptyline and mianserin increase DA release in the nucleus accumbens by blocking 5-HT2C receptors.

Amitriptyline Mianserin Dopamine release Nucleus accumbens Microdialysis 

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Copyright information

© Springer-Verlag 2000

Authors and Affiliations

  • Vincenzo Di Matteo
    • 1
  • Michele Di Mascio
    • 1
  • Giuseppe Di Giovanni
    • 2
  • Ennio Esposito
    • 1
  1. 1.Istituto di Ricerche Farmacologiche "Mario Negri", Consorzio "Mario Negri" Sud, 66030 Santa Maria Imbaro (Chieti), Italy
  2. 2.Dipartimento di Oncologia-Neuroscienze, Istituto di Neurologia, Università "G. D'Annunzio", Chieti, Italy

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