There is a growing body of evidence demonstrating the therapeutic potential of ayahuasca for treating depression and anxiety. However, the mechanisms of action involved in ayahuasca’s therapeutic effects are unclear. Mindfulness and cognitive flexibility may be two possible psychological mechanisms. Like other classic psychedelics, ayahuasca also leads to an ‘afterglow’ effect of improved subjective well-being that persists after the acute effects have subsided. This period may offer a window of increased therapeutic potential.
To explore changes in mindfulness and cognitive flexibility before and within 24 h after ayahuasca use.
Forty-eight participants (54% female) were assessed on measures of mindfulness (Five Facets Mindfulness Questionnaire (FFMQ)), decentering (Experiences Questionnaire (EQ)), and cognitive flexibility (Cognitive Flexibility Scale (CFS)), and completed the Stroop and Wisconsin Picture Card Sorting Task (WPCST) before drinking ayahuasca, and again within 24 h.
Mindfulness (FFMQ total scores and four of the five mindfulness facets: observe, describe, act with awareness, and non-reactivity) and decentering (EQ) significantly increased in the 24 h after ayahuasca use. Cognitive flexibility (CFS and WPCST) significantly improved in the 24 h after ayahuasca use. Changes in both mindfulness and cognitive flexibility were not influenced by prior ayahuasca use.
The present study supports ayahuasca’s ability to enhance mindfulness and further reports changes in cognitive flexibility in the ‘afterglow’ period occur, suggesting both could be possible psychological mechanisms concerning the psychotherapeutic effects of ayahuasca. Given psychological gains occurred regardless of prior ayahuasca use suggests potentially therapeutic effects for both naïve and experienced ayahuasca drinkers.
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Alonso JF, Romero S, Mañanas MÀ, Riba J (2015) Serotonergic psychedelics temporarily modify information transfer in humans. Int J Neuropsychopharmacol 18(8). https://doi.org/10.1093/ijnp/pyv039
Baer RA, Smith GT, Hopkins J, Krietemeyer J, Toney L (2006) Using self-report assessment methods to explore facets of mindfulness. Assessment 13(1):27–45
Baer RA, Smith GT, Lykins E, Button D, Krietemeyer J, Sauer S, Williams JM (2008) Construct validity of the Five Facet Mindfulness Questionnaire in meditating and nonmeditating samples. Assessment 15(3):329–342
Barbosa PC, Strassman RJ, Da Silveira DX, Areco K, Hoy R, Pommy J, Bogenschutz M (2016) Psychological and neuropsychological assessment of regular hoasca users. Comprehensive Psychiatry 71:95–105
Berg EA (1948) A simple objective technique for measuring flexibility in thinking. J Gen Psychol 39(1):15–22
Bissonette GB, Powell EM, Roesch MR (2013) Neural structures underlying set-shifting: roles of medial prefrontal cortex and anterior cingulate cortex. Behav Brain Res 250:91–101
Bohlmeijer E, Ten Klooster PM, Fledderus M, Veehof M, Baer R (2011) Psychometric properties of the Five Facet Mindfulness Questionnaire in Depressed Adults and Development of a Short Form. Assessment 18(3):308–320
Bouso JC, Riba J (2014) Ayahuasca and the treatment of drug addiction. In: Labate B, Canvar C (eds) The therapeutic use of ayahuasca. Springer, Berlin, pp 95–109
Bouso JC, González D, Fondevila S, Cutchet M, Fernández X, Ribeiro Barbosa PC, Riba J (2012) Personality, psychopathology, life attitudes and neuropsychological performance among ritual users of ayahuasca: a longitudinal study. PLoS One 7(8):e42421
Bouso JC, Fábregas JM, Antonijoan RM, Rodríguez-Fornells A, Riba J (2013) Acute effects of ayahuasca on neuropsychological performance: differences in executive function between experienced and occasional users. Psychopharmacology 230(3):415–424
Bouso JC, Palhano-Fontes F, Rodríguez-Fornells A, Ribeiro S, Sanches R, Crippa JA, Riba J (2015) Long-term use of psychedelic drugs is associated with differences in brain structure and personality in humans. Eur Neuropsychopharmacol 25(4):483–492
Carhart-Harris RL, Leech R, Hellyer PJ, Shanahan M, Feilding A, Tagliazucchi E, Nutt D (2014) The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs. Front Hum Neurosci:8
Doering-Silveira E, Lopez E, Grob CS, De Rios MD, Alonso LK, Tacla C et al (2005) Ayahuasca in adolescence: a neuropsychological assessment. J Psychoactive Drugs 37(2):123–128
Dominguez-Clavé E, Soler J, Elices M, Pascual JC, Alvarez E, de la Fuente Revenga M, Friedlander P, Feilding A, Riba J (2016) Ayahuasca: pharmacology, neuroscience and therapeutic potential. Brain Res Bull 126(Pt 1):89–101
Fresco DM, Moore MT, Van Dulmen MH, Segal ZV, Ma SH, Teasdale JD, Williams JM (2007) Initial psychometric properties of the experiences questionnaire: validation of a self-report measure of decentering. Behav Ther 38(3):234–246
Goldberg S, Tucker R, Greene P, Davidson R, Wampold B, Kearney D, Simpson T (2018) Mindfulness-based interventions for psychiatric disorders: a systematic review and meta-analysis. Clin Psychol Rev 59:52–60
Gossop, M. (1995). Severity of Dependence Scale. PsycTESTS Dataset
Gouzoulis-Mayfrank E, Thelen B, Habermeyer E, Kunert HJ, Kovar K, Lindenblatt H et al (1999) Psychopathological, neuroendocrine and autonomic effects of 3,4-methylenedioxyethylamphetamine (MDE), psilocybin and d -methamphetamine in healthy volunteers. Psychopharmacology 142(1):41–50
Griffiths RR, Johnson MW, Carducci MA, Umbricht A, Richards WA, Richards BD, Cosimano MP, Klinedinst MA (2016) Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: a randomized double blind trial. J Psychopharmacol 30(12):1181–1197
Grob CS, Danforth AL, Chopra GS, Hagerty M, McKay CR, Halberstadt AL, Greer GR (2011) Pilot study of psilocybin treatment for anxiety in patients with advanced-stage cancer. Arch Gen Psychiatry 68(1):71–78
Hayes SC, Luoma JB, Bond FW, Masuda A, Lillis J (2006) Acceptance and commitment therapy: model, processes and outcomes. Behav Res Ther 44(1):1–25
Hayes-Skelton S, Graham J (2013) Decentering as a common link among mindfulness, cognitive reappraisal, and social anxiety. Behav Cogn Psychother 41(3):317–328
Heaton RK (1981) A manual for the Wisconsin Card Sorting Test. Western Psychological Services, Los Angeles
Hermle L, Fünfgeld M, Oepen G, Botsch H, Borchardt D, Gouzoulis E, Spitzer M (1992) Mescaline induced psychopathological, neuropsychological, and neurometabolic effects in normal subjects: experimental psychosis as a tool for psychiatric research. Biol Psychiatry 32(11):976–991
Johnco C, Wuthrich V, Rapee R (2014) The influence of cognitive flexibility on treatment outcome and cognitive restructuring skill acquisition during cognitive behavioural treatment for anxiety and depression in older adults: results of a pilot study. Behav Res Ther 57:55–64
Kabat-Zinn J (2003) Mindfulness-based interventions in context: past, present, and future. Clin Psychol Sci Pract 10(2):144–156
Kim C, Johnson NF, Cilles SE, Gold BT (2011) Common and distinct mechanisms of cognitive flexibility in prefrontal cortex. J Neurosci 31(13):4771–4779
Kuypers KP, Riba J, De la Fuente Revenga M, Barker S, Theunissen EL, Ramaekers JG (2016) Ayahuasca enhances creative divergent thinking while decreasing conventional convergent thinking. Psychopharmacology 233(18):3395–3403
Lee JK, Orsillo SM (2014) Investigating cognitive flexibility as a potential mechanism of mindfulness in generalized anxiety disorder. J Behav Ther Exp Psychiatry 45(1):208–216
Leinonen TIK-M (2000) Impaired Wisconsin Card Sorting Test performance in first-episode severe depression. Nordic Journal of Psychiatry 54(4):275–280
Martin, M. M., & Rubin, R. B. (1995). A new measure of cognitive flexibility. Psychological Reports, 76(2):
Moreno FA, Wiegand CB, Taitano EK, Delgado PL (2006) Safety, tolerability, and efficacy of psilocybin in 9 patients with obsessive-compulsive disorder. J Clin Psychiatry 67(11):1735–1740
Palhano-Fontes F, Andrade KC, Tofoli LF, Santos AC, Crippa JA, Hallak JE, De Araujo DB (2015) The psychedelic state induced by ayahuasca modulates the activity and connectivity of the default mode network. PLoS One 10(2):e0118143
Pang D, Ruch W (2018) Scrutinizing the components of mindfulness: insights from current, past, and non-meditators. Mindfulness 10(3):492–505
Prickett JI, Liester MB (2002) Hypotheses regarding ayahuasca’s potential mechanisms of action in the treatment of addiction. In: Labate B, Canvar C (eds) The therapeutic use of ayahuasca. Springer, Berlin, pp 111–132
Riba J, Romero S, Grasa E, Mena E, Carrió I, Barbanoj MJ (2006) Increased frontal and paralimbic activation following ayahuasca, the pan-amazonian inebriant. Psychopharmacology 186(1):93–98
Sampedro F, De la Fuente Revenga M, Valle M, Roberto N, Domínguez-Clavé E, Elices M, Riba J (2017) Assessing the psychedelic “after-glow” in ayahuasca users: post-acute neurometabolic and functional connectivity changes are associated with enhanced mindfulness capacities. Int J Neuropsychopharmacol 20(9):698–711
Soler J, Franquesa A, Feliu-Soler A, Cebolla A, García-Campayo J, Tejedor R, Portella MJ (2014) Assessing decentering: validation, psychometric properties, and clinical usefulness of the experiences questionnaire in a Spanish sample. Behav Ther 45(6):863–871
Soler J, Elices M, Franquesa A, Barker S, Friedlander P, Fielding A, Pascual JC, Riba J (2016) Exploring the therapeutic potential of ayahuasca: acute intake increases mindfulness-related capacities. Psychopharmacology 233:823–829
Soler J, Elices M, Dominguez-Clavé E, Pascual JC, Feilding A, Navarro-Gil M, Riba J (2018) Four weekly ayahuasca sessions lead to increases in “acceptance” capacities: a comparison study with a standard 8-week mindfulness training program. Front Pharmacol 9
Stroop, J. R. (1935). Stroop Color Interference Test. PsycTESTS Dataset
Uthaug MV, van Oorsouw K, Kuypers KPC, van Boxtel M, Broers NJ, Mason NL, Toennes SW, Rib J, Ramaekers JG (2018) Sub-acute and long-term effects of ayahuasca on affect and cognitive thinking style and their association with ego dissolution. Psychopharmacology 235:2979–2989
Vollenweider FX, Kometer M (2010) The neurobiology of psychedelic drugs: implications for the treatment of mood disorders. Nat Rev Neurosci 11:642–651
Vollenweider FX, Leenders KL, Scharfetter C, Maguire P, Stadelmann O, Angst J (1997) Positron emission tomography and fluorodeoxyglucose studies of metabolic hyperfrontality and psychopathology in the psilocybin model of psychosis. Neuropsychopharmacology 16:357–372
The study was granted ethical approval by the School of Psychology, University of East London’s Ethics Committee.
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Murphy-Beiner, A., Soar, K. Ayahuasca’s ‘afterglow’: improved mindfulness and cognitive flexibility in ayahuasca drinkers. Psychopharmacology (2020). https://doi.org/10.1007/s00213-019-05445-3
- Cognitive flexibility
- Psychological flexibility
- Psychological mechanisms