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Effects of nicotine on smooth pursuit eye movements in healthy non-smokers

  • Inga Meyhöfer
  • Anna-Maria Kasparbauer
  • Maria Steffens
  • Ulrich EttingerEmail author
Original Investigation

Abstract

Rationale

The non-selective nicotinic acetylcholine receptor (nAChR) agonist nicotine has been argued to improve attention via enhanced filtering of irrelevant stimuli. Here, we tested this hypothesis in the context of smooth pursuit eye movements (SPEMs), an oculomotor function previously shown to improve with nicotine in some but not all studies.

Objectives

In order to test whether nicotine improves performance particularly when the inhibition of distracting stimuli is required, SPEM was elicited in conditions with or without peripheral distractors. Additionally, different target frequencies were employed in order to parametrically vary general processing demands on the SPEM system.

Methods

Healthy adult non-smokers (N = 18 females, N = 13 males) completed a horizontal sinusoidal SPEM task at different target frequencies (0.2 Hz, 0.4 Hz, 0.6 Hz) in the presence or absence of peripheral distractors in a double-blind, placebo-controlled, cross-over design using a 2 mg nicotine gum.

Results

Nicotine increased peak pursuit gain relative to placebo (p < .001), but an interaction with distractor condition (p = .001) indicated that this effect was most pronounced in the presence of distractors. Catch-up saccade frequency was reduced by nicotine (p = .01), particularly at higher target frequencies (two-way interaction, p = .04). However, a three-way interaction (p = .006) indicated that the reduction with nicotine was strongest at the highest target frequency (0.6 Hz) only without distractors, whereas in the presence of distractors, it was strongest at 0.4-Hz target frequency. There were no effects of nicotine on subjective state measures.

Conclusions

Together, these findings support a role of both distractor inhibition and general processing load in the effects of nicotine on smooth pursuit.

Keywords

Nicotine Oculomotor control Attention Inhibition 

Notes

Acknowledgments

We are grateful to the Nicotine Science Center at Fertin Pharma A/S for providing the nicotine and placebo gums. We would like to thank Felix Benninghoff-Lühl, Christina Esser, Adrian Pick and Carina Steinberg for their excellent support in data collection.

Compliance with ethical standards

Approval of the local ethics committee was obtained and the study was conducted in agreement with the latest version of the Code of Ethics of the World Medical Association (Declaration of Helsinki).

Conflict of interest

The authors declare that they have no conflicts of interest.

Supplementary material

213_2019_5223_MOESM1_ESM.docx (82 kb)
ESM 1 (DOCX 82 kb)

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© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of PsychologyUniversity of BonnBonnGermany
  2. 2.Department of Psychiatry and Psychotherapy, Otto Creutzfeldt Center for Cognitive and Behavioral NeuroscienceUniversity of MuensterMuensterGermany

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