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Psychopharmacology

, Volume 235, Issue 9, pp 2587–2595 | Cite as

The effect of dopamine on conditioned placebo analgesia in healthy individuals: a double-blind randomized trial

  • Matthias Zunhammer
  • Magnus Gerardi
  • Ulrike Bingel
Original Investigation
  • 144 Downloads

Abstract

Rationale

Better means to control placebo effects are key to optimizing treatment outcomes. Dopamine-based reward and learning mechanisms have been hypothesized to drive placebo effects. Here, we tested whether dopamine augmentation can modulate learned placebo effects.

Methods

We performed a randomized, double-blind parallel group study with 70 healthy adult participants to test whether a single oral dose of the dopamine precursor levodopa/carbidopa (100/25 mg) administered before the acquisition of conditioned placebo analgesia enhances the placebo response in an established experimental placebo model using heat pain.

Results

Overall, the observed levels of placebo analgesia in our sample were low and not statistically significant. Levodopa, compared to placebo, only led to a marginal increase in placebo analgesia. Female participants tended to show larger placebo responses than male participants. Within the female subgroup, levodopa showed small-to-moderate effects on placebo analgesia; however, this effect was not statistically significant.

Conclusions

In summary, the present study could not provide evidence for a placebo augmenting effect of levodopa-enhanced dopamine levels in healthy subjects. Further studies are needed to elucidate whether placebo enhancement can be achieved through dopamine augmentation.

Keywords

Human Placebo Analgesia l-DOPA Conditioning Experimental pain 

Notes

Compliance with ethical standards

Conflicts of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Klinik für NeurologieUniversitätsklinikum EssenEssenGermany

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