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Psychopharmacology

, Volume 235, Issue 7, pp 1981–1985 | Cite as

Social reinforcement as alternative to sucrose reinforcement is increased by nicotine and methylphenidate in male Fischer-344 rats

  • Connor D. Martin
  • Heather M. Bool
  • Anthony M. George
  • Katelyn A. Carr
  • Leonard H. Epstein
  • Larry W. HawkJr
  • Jerry B. Richards
Original Investigation
  • 142 Downloads

Abstract

Background

Stimulant drugs such as nicotine (NIC) and methylphenidate (MPH) are hypothesized to increase the reinforcing value of sensory stimuli, thus increasing the effectiveness of such reinforcers as alternatives to sucrose reinforcers.

Methods

Inbred Fischer-344 rats (n = 30) were assigned to three groups: saline (SAL; n = 10), nicotine (NIC; n = 10), or methylphenidate (MPH; n = 10). Testing was done in three phases: sucrose only, (SUC), sucrose and drug (SUC/DRUG), and sucrose, drug, and social reinforcement (SUC/DRUG/SOC). During the SUC phase, rats were trained on a progressive ratio 5 (PR5) reinforcement schedule for sucrose (20% solution). In the SUC/DRUG phase, animals were treated with SAL, NIC (0.4 mg/kg, n = 10 SC), or MPH (2.0 mg/kg, n = 10 IP) 30 min prior to testing. In the SUC/DRUG/SOC phase, animals continued receiving drug treatment, and social reinforcement was introduced concurrently with the sucrose reinforcer. The progressive ratio for each reinforcer ran independently of the others. Reinforcing value was measured as break point (BP), the highest number of responses resulting in a reinforcer.

Results

SAL-treated animals showed no significant change in sucrose BP. MPH-treated animals showed decreased sucrose BP in the SUC/DRUG phase, with a further reduction in the SUC/DRUG/SOC phase. NIC-treated animals decreased sucrose BP only when a social alternative was offered.

Conclusion

Both NIC and MPH reduce the sucrose BP in the presence of a social alternative. The decrease in sucrose responding, coupled with increased social responding, suggests that the social alternative acted as an effective alternative reinforcer to sucrose. From a translational perspective, these results suggest that stimulant drugs such as NIC and MPH may increase the effectiveness of treatments that use alternative social reinforcers to decrease eating.

Keywords

Behavioral economics Operant Progressive ratio Social behavior 

Notes

Funding information

This work was supported by a grant from the center for translational research at the University of Buffalo and a grant from the National Institute of Drug Abuse (P50DA037844).

Supplementary material

213_2018_4896_MOESM1_ESM.mp4 (23.7 mb)
ESM 1 (MP4 24,232 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Connor D. Martin
    • 1
  • Heather M. Bool
    • 1
  • Anthony M. George
    • 1
  • Katelyn A. Carr
    • 2
  • Leonard H. Epstein
    • 2
  • Larry W. HawkJr
    • 3
  • Jerry B. Richards
    • 1
  1. 1.Research Institute on AddictionsUniversity of BuffaloBuffaloUSA
  2. 2.Division of Behavioral Medicine, PediatricsUniversity of BuffaloBuffaloUSA
  3. 3.Department of PsychologyUniversity of BuffaloBuffaloUSA

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