Psychopharmacology

, Volume 235, Issue 4, pp 1041–1054 | Cite as

Earlier alcohol use onset prospectively predicts changes in functional connectivity

  • Tam T. Nguyen-Louie
  • Alan N. Simmons
  • Lindsay M. Squeglia
  • M. Alejandra Infante
  • Joseph P. Schacht
  • Susan F. Tapert
Original Investigation

Abstract

Background

Half of all new alcohol initiates are between 12 and 17 years old. This is a period of intense neurodevelopment, including changes in functional connectivity patterns among higher-order function areas. It is crucial to understand how alcohol-related neurotoxicity may be influenced by drinking onset age.

Design

This study prospectively examined the effects of age of first drink on frontoparietal context-dependent functional connectivity (cdFC) during a visual working memory task. Youth 13.5 years of age (SD = 1.2) underwent a neuropsychological and neuroimaging session before drinking initiation and at follow-up 6 years later. Hierarchical linear regressions examined if youth with earlier ages of onset for first and weekly alcohol use showed higher follow-up cdFC between the dorsolateral prefrontal cortex and posterior parietal cortex regions of interest and whole-brain exploratory regions, controlling for pre-drinking cdFC. Higher follow-up cdFC was hypothesized to be correlated with poorer performances in neuropsychological performance.

Results

Exploratory whole-brain analyses showed that, as hypothesized, earlier ages of weekly drinking onset were associated with higher cdFC between the bilateral posterior cingulate and cortical and subcortical areas implicated in attentional processes, which was in turn associated with poorer performance on neuropsychological tasks of attention, ps < .05. No relationship between age of onset and cdFC between the two ROIs were found.

Conclusion

Earlier ages of weekly alcohol use initiation may adversely affect neurodevelopment by reducing developmentally appropriate integration of attentional circuits during a cognitive challenge. Delaying the onset of weekly alcohol use patterns well after early adolescence may reduce the risk for harm of alcohol use on the brain.

Keywords

Anticorrelations Alcohol use Alcohol onset Context-dependent functional connectivity 

Notes

Acknowledgements

The authors thank the participants, family, and other informants; the San Diego Unified School District; and the outstanding research staff: Norma Castro, Claudia Cota, and Irene Lee. This study was supported by National Institute on Alcohol Abuse and Alcoholism Grants R01 AA13419, U01 AA021695 (PI: Tapert), T32 AA013525 (PI: Riley), and F31 AA024389 (PI: Nguyen-Louie).

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.San Diego State University/University of California San Diego Joint Doctoral Program in Clinical PsychologySan DiegoUSA
  2. 2.Department of PsychiatryUniversity of California San DiegoSan DiegoUSA
  3. 3.Department of Psychiatry and Behavioral SciencesMedical University of South CarolinaCharlestonUSA

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