Blunted stress reactivity in chronic cannabis users
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One of the most commonly cited reasons for chronic cannabis use is to cope with stress. Consistent with this, cannabis users have shown reduced emotional arousal and dampened stress reactivity in response to negative imagery.
To our knowledge, the present study represents the first to examine the effects of an acute stress manipulation on subjective stress and salivary cortisol in chronic cannabis users compared to non-users.
Forty cannabis users and 42 non-users were randomly assigned to complete either the stress or no stress conditions of the Maastricht Acute Stress Test (MAST). The stress condition of the MAST manipulates both physiological (placing hand in ice bath) and psychosocial stress (performing math under conditions of social evaluation). Participants gave baseline subjective stress ratings before, during, and after the stress manipulation. Cortisol was measured from saliva samples obtained before and after the stress manipulation. Further, cannabis cravings and symptoms of withdrawal were measured.
Subjective stress ratings and cortisol levels were significantly higher in non-users in the stress condition relative to non-users in the no stress condition. In contrast, cannabis users demonstrated blunted stress reactivity; specifically, they showed no increase in cortisol and a significantly smaller increase in subjective stress ratings. The stress manipulation had no impact on cannabis users’ self-reported cravings or withdrawal symptoms.
Chronic cannabis use is associated with blunted stress reactivity. Future research is needed to determine whether this helps to confer resiliency or vulnerability to stress-related psychopathology as well as the mechanisms underlying this effect.
KeywordsCannabis Marijuana Stress Cortisol Craving Withdrawal
Washington State University’s Dedicated Marijuana Account funded this study. We thank Anthony Berger for running the cortisol assays.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
- Buckner JD, Zvolensky MJ, Ecker AH, Jeffries ER (2016) Cannabis craving in response to laboratory-induced social stress among racially diverse cannabis users: the impact of social anxiety disorder. J Psychopharmacol 30(4):363–369. doi: 10.1177/0269881116629115 CrossRefPubMedPubMedCentralGoogle Scholar
- Childs E, Lutz JA, de Wit H (2017) Dose-related effects of delta-9-THC on emotional responses to acute psychosocial stress. Drug Alcohol Depend (in press)Google Scholar
- Cohen S, Williamson G (1988) Perceived stress in a probability sample of the United States. In: Spacapan S, Oskamp S (eds) The social psychology of health: Claremont symposium on applied social psychology. Newbury Park, CaliforniaGoogle Scholar
- Cuttler C, Spradlin A (2017) Measuring cannabis consumption. Psychometric properties of the Daily Sessions, Frequency, Age of Onset, and Quantity of Cannabis Use Inventory (DFAQ-CU). PLOS ONE (in press)Google Scholar
- Di Marzo V, Berrendero F, Bisogno T, González S, Cavaliere P, Romero J, Cebeira M, Ramos JA, Fernández-Ruiz JJ (2000) Enhancement of anandamide formation in the limbic forebrain and reduction of endocannabinoid contents in the striatum of delta9-tetrahydrocannabinol-tolerant rats. J Neurochem 74(4):1627–1635CrossRefPubMedGoogle Scholar
- González S, Fernández-Ruiz J, Di Marzo V, Hernández M, Arévalo C, Nicanor C, Cascio MG, Ambrosio E, Ramos JA (2004) Behavioral and molecular changes elicited by acute administration of SR141716 to Delta9-tetrahydrocannabinol-tolerant rats: an experimental model of cannabinoid abstinence. Drug Alcohol Depend 74(2):159–170. doi: 10.1016/j.drugalcdep.2003.12.011 CrossRefPubMedGoogle Scholar
- Hill MN, McLaughlin RJ, Pan B, Fitzgerald ML, Roberts CJ, Lee TT, Karatsoreos IN, Mackie K, Viau V, Pickel VM, McEwen BS, Liu QS, Gorzalka BB, Hillard CJ (2011) Recruitment of prefrontal cortical endocannabinoid signaling by glucocorticoids contributes to termination of the stress response. J Neurosci 31(29):10506–10515. doi: 10.1523/JNEUROSCI.0496-11.2011 CrossRefPubMedPubMedCentralGoogle Scholar
- King GR, Ernst T, Deng W, Stenger A, Gonzales RM, Nakama H, Chang L (2011) Altered brain activation during visuomotor integration in chronic active cannabis users: relationship to cortisol levels. J Neurosci 31(49):17923–17931. doi: 10.1523/JNEUROSCI.4148-11.2011 CrossRefPubMedPubMedCentralGoogle Scholar
- Malcher-Lopes R, Di S, Marcheselli VS, Weng FJ, Stuart CT, Bazan NG, Tasker JG (2006) Opposing crosstalk between leptin and glucocorticoids rapidly modulates synaptic excitation via endocannabinoid release. J Neurosci 26(24):6643–6650. doi: 10.1523/JNEUROSCI.5126-05.2006 CrossRefPubMedGoogle Scholar
- Monteleone P, Di Filippo C, Fabrazzo M, Milano W, Martiadis V, Corrivetti G, Monteleone AM, Maj M (2014) Flattened cortisol awakening response in chronic patients with schizophrenia onset after cannabis exposure. Psychiatry Res 215(2):263–267. doi: 10.1016/j.psychres.2013.12.016 CrossRefPubMedGoogle Scholar
- Schuermeyer J, Salomonsen-Sautel S, Price RK, Balan S, Thurstone C, Min SJ, Sakai JT (2014) Temporal trends in marijuana attitudes, availability and use in Colorado compared to non-medical marijuana states: 2003-11. Drug Alcohol Depend 140:145–155. doi: 10.1016/j.drugalcdep.2014.04.016 CrossRefPubMedPubMedCentralGoogle Scholar
- Smeets T, Cornelisse S, Quaedflieg CW, Meyer T, Jelicic M, Merckelbach H (2012) Introducing the Masstricht Acute Stress Test (MAST): a quick and non-invasive approach to elicit robust autonomic and glucocorticoid stress responses. Psychneuroendocrinology 37:1998–2008. doi: 10.1016/j.psyneuen.2012.04.012 CrossRefGoogle Scholar
- Sotnikov S, Wittmann A, Bunck M, Bauer S, Deussing J, Schmidt M, Touma C, Landgraf R, Czibere L (2014) Blunted HPA axis reactivity reveals glucocorticoid system dysbalance in a mouse model of high anxiety-related behavior. Psychoneuroendocrinology 48:41–51. doi: 10.1016/j.psyneuen.2014.06.006 CrossRefPubMedGoogle Scholar
- Substance Abuse and Mental Health Services Administration (SAMHSA) (2014). Behavioral health trends in the United States: results from the 2014 National Survey on Drug Use and Health. Retrieved March 15th, from http://www.samhsa.gov/data/sites/default/files/NSDUH-FRR1-2014/NSDUH-FRR1-2014.pdf
- United Nations Office on Drugs and Crime (2012) World drug report. United Nations, New YorkGoogle Scholar
- Urry HL, van Reekum CM, Johnstone T, Kalin NH, Thurow ME, Schaefer HS, Jackson CA, Frye CJ, Greischar LL, Alexander AL, Davidson RJ (2006) Amygdala and ventromedial prefrontal cortex are inversely coupled during regulation of negative affect and predict the diurnal pattern of cortisol secretion among older adults. J Neurosci 26(16):4415–4425. doi: 10.1523/JNEUROSCI.3215-05.2006 CrossRefPubMedGoogle Scholar
- Volkow ND, Wang GJ, Telang F, Fowler JS, Alexoff D, Logan J, Jayne M, Wong C, Tomasi D (2014) Decreased dopamine brain reactivity in marijuana abusers is associated with negative emotionality and addiction severity. Proc Natl Acad Sci U S A 111(30):E3149–E3156. doi: 10.1073/pnas.1411228111 CrossRefPubMedPubMedCentralGoogle Scholar