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Psychopharmacology

, Volume 234, Issue 1, pp 63–71 | Cite as

Medications influencing central cholinergic neurotransmission affect saccadic and smooth pursuit eye movements in healthy young adults

  • Preshanta Naicker
  • Shailendra Anoopkumar-Dukie
  • Gary D. Grant
  • Justin J. KavanaghEmail author
Original Investigation

Abstract

Rationale

Acetylcholine is an important neuromodulator in the central nervous system, where it plays a significant role in central functions such as the regulation of movement.

Objective

This study investigated the pharmacological effects of over-the-counter anticholinergic medications on saccadic and smooth pursuit eye movements, in order to establish the significance of central cholinergic pathways in the control of these centrally regulated oculomotor processes.

Methods

Sixteen subjects (mean age 23 ± 3 years, 9 females) performed pro-saccadic, anti-saccadic and smooth pursuit eye movement tests, while an eye tracker collected eye movement data. Oculomotor assessments were performed pre-ingestion, 0.5 and 2 h post-ingestion of drugs with varying degrees of central anticholinergic properties. The drugs tested were promethazine, hyoscine hydrobromide, hyoscine butylbromide and placebo.

Results

The drug intervention with stronger central anticholinergic properties, promethazine, decreased amplitude and increased velocity in the pro-saccadic task and increased duration in the anti-saccadic task. Promethazine, once again, was the only drug to decrease eye velocity in the smooth pursuit test.

Conclusion

The prominent effects of the stronger central anticholinergic promethazine, on saccadic and smooth pursuit eye movements, potentially conveys the significance of central cholinergic pathways in the control of these centrally regulated oculomotor processes.

Keywords

Anticholinergic Saccadic eye movement Smooth pursuit Oculomotor Neurotransmitter 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Preshanta Naicker
    • 1
    • 2
  • Shailendra Anoopkumar-Dukie
    • 1
    • 2
  • Gary D. Grant
    • 1
    • 2
  • Justin J. Kavanagh
    • 1
    • 3
    Email author
  1. 1.Menzies Health InstituteGriffith UniversityGold CoastAustralia
  2. 2.School of PharmacyGriffith UniversityGold CoastAustralia
  3. 3.Centre for Musculoskeletal ResearchGriffith UniversityGold CoastAustralia

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