Abnormal fronto-limbic engagement in incarcerated stimulant users during moral processing
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Stimulant use is a significant and prevalent problem, particularly in criminal populations. Previous studies found that cocaine and methamphetamine use is related to impairment in identifying emotions and empathy. Stimulant users also have abnormal neural structure and function of the ventromedial prefrontal cortex (vmPFC), amygdala, and anterior (ACC) and posterior cingulate (PCC), regions implicated in moral decision-making. However, no research has studied the neural correlates of stimulant use and explicit moral processing in an incarcerated population.
Here, we examine how stimulant use affects sociomoral processing that might contribute to antisocial behavior. We predicted that vmPFC, amygdala, PCC, and ACC would show abnormal neural response during a moral processing task in incarcerated methamphetamine and cocaine users.
Incarcerated adult males (N = 211) were scanned with a mobile MRI system while completing a moral decision-making task. Lifetime drug use was assessed. Neural responses during moral processing were compared between users and non-users. The relationship between duration of use and neural function was also examined.
Incarcerated stimulant users showed less amygdala engagement than non-users during moral processing. Duration of stimulant use was negatively associated with activity in ACC and positively associated with vmPFC response during moral processing.
These results suggest a dynamic pattern of fronto-limbic moral processing related to stimulant use with deficits in both central motive and cognitive integration elements of biological moral processes theory. This increases our understanding of how drug use relates to moral processing in the brain in an ultra-high-risk population.
KeywordsMorality fMRI Cocaine Methamphetamine Stimulant vmPFC ACC Limbic
Research reported in this publication was supported by the National Institute of Mental Health and National Institute on Drug Abuse under R01MH070539, R01DA026964, and R01DA026505 to Kent A. Kiehl. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Compliance with ethical standards
All participants provided written, informed consent prior to their inclusion in the study and were compensated at an hourly rate comparable to pay rates for work within the facilities. All procedures and materials were approved by the University of New Mexico Institutional Review Board (IRB) and thus have been performed in accordance with the ethical standards of the Declaration of Helsinki.
Conflict of interest
The authors do not have any financial conflicts of interest.
- Alia-Klein N, Parvaz MA, Woicik PA, Konova AB, Maloney T, Shumay E, Wang RL, Telang F, Biegon A, Wang GJ, Fowler JS, Tomasi D, Volkow ND, Goldstein RZ (2011) Gene x disease interaction on orbitofrontal gray matter in cocaine addiction. Arch Gen Psychiatry 68:283–294CrossRefPubMedPubMedCentralGoogle Scholar
- BJS BoJS (2004) Drug use and dependence, state and federal prisonersGoogle Scholar
- Daumann J, Koester P, Becker B, Wagner D, Imperati D, Gouzoulis-Mayfrank E, Tittgemeyer M (2011) Medial prefrontal gray matter volume reductions in users of amphetamine-type stimulants revealed by combined tract-based spatial statistics and voxel-based morphometry. Neuroimage 54:794–801CrossRefPubMedGoogle Scholar
- Ersche KD, Williams GB, Robbins TW, Bullmore ET (2013) Meta-analysis of structural brain abnormalities associated with stimulant drug dependence and neuroimaging of addiction vulnerability and resilience. Curr Opin Neurobiol 23:615–624Google Scholar
- First M, Spitzer R, Williams J, Gibbon M (1997) Structured Clinical Interview for DSM-IV (SCID), 1997. American Psychiatric Association, Washington, DCGoogle Scholar
- Fox HC, Bergquist KL, Casey J, Hong KA, Sinha R (2011) Selective cocaine-related difficulties in emotional intelligence: relationship to stress and impulse control. Am J Addiction 20:151–160Google Scholar
- Hare RD (2003) Manual for the Hare Psychopathy Checklist-Revised. Multi-Health Systems, TorontoGoogle Scholar
- Huang B, Dawson DA, Stinson FS, Hasin DS, Ruan W, Saha TD, Smith SM, Goldstein RB and Grant BF (2006) Prevalence, correlates, and comorbidity of nonmedical prescription drug use and drug use disorders in the United States: results of the National Epidemiologic Survey on Alcohol and Related Conditions. J Clin Psychiatry 67:1062–1073Google Scholar
- Kim YT, Kwon DH and Chang YM (2011a) Impairments of facial emotion recognition and theory of mind in methamphetamine abusers. Psychiat Res 186:80–84.Google Scholar
- Kim MJ, Loucks RA, Palmer AL, Brown AC, Solomon KM, Marchante AN and Whalen PJ (2011b) The structural and functional connectivity of the amygdala: from normal emotion to pathological anxiety. Behav Brain Res 223:403–410.Google Scholar
- Kohno M, Okita K, Morales AM, Robertson CL, Dean AC, Ghahremani DG, Sabb FW, Rawson RA, Mandelkern MA, Bilder RM, London ED (2016) Midbrain functional connectivity and ventral striatal dopamine D2-type receptors: link to impulsivity in methamphetamine users. Mol Psychiatry. doi: 10.1038/mp.2015.223
- NIDA NIoDA (2014) Trends & statistics.Google Scholar
- SAMSHA SAaMHSA (2011) Results from the 2010 National Survey on Drug Use and Health: summary of national findings. In: NSDUH Series H-41. Substance Abuse and Mental Health Services Administration (SAMHSA), RockvilleGoogle Scholar
- SAMSHA SAaMHSA (2014) Results from the 2013 National Survey on Drug Use and Health: summary of national findings. Substance Abuse and Mental Health Services Administration, RockvilleGoogle Scholar
- Psychological Software Tools (2012) E-Prime. Psychological Software Tools, PittsburghGoogle Scholar
- Urry HL, Van Reekum CM, Johnstone T, Kalin NH, Thurow ME, Schaefer HS, Jackson CA, Frye CJ, Greischar LL, Alexander AL (2006) Amygdala and ventromedial prefrontal cortex are inversely coupled during regulation of negative affect and predict the diurnal pattern of cortisol secretion among older adults. J Neurosci 26:4415–4425CrossRefPubMedGoogle Scholar
- Verdejo-Garcia A, Contreras-Rodríguez O, Fonseca F, Cuenca A, Soriano-Mas C, Rodriguez J, Pardo-Lozano R, Blanco-Hinojo L, de Sola LS, Farré M, Torrens M, Pujol J, de la Torre R (2014) Functional alteration in frontolimbic systems relevant to moral judgment in cocaine-dependent subjects. Addict Biol 19:272–281CrossRefPubMedGoogle Scholar
- Wechsler D (1997) WAIS-III: administration and scoring manual: Wechsler Adult Intelligence Scale. Psychological Corporation, San Antonio, TXGoogle Scholar