Psychopharmacology

, Volume 233, Issue 8, pp 1537–1537 | Cite as

Erratum to: mGluR2/3 agonist LY379268 rescues NMDA and GABAA receptor level deficits induced in a two-hit mouse model of schizophrenia

  • Martin Engel
  • Peta Snikeris
  • Natalie Matosin
  • Kelly Anne Newell
  • Xu-Feng Huang
  • Elisabeth Frank
Erratum

Erratum to: Psychopharmacology

DOI 10.1007/s00213-016-4230-0

Legends of Figs. 1, 2 and 3 were misplaced in the original version of this article. Correct legends are presented below:

Fig. 1 Acute LY379268 and olanzapine treatment restore NMDA-R binding density levels in several brain regions of two-hit NRG1 HET (PCP) mice. Wild type mice (WT) and neuregulin 1 heterozygous transmembrane domain knockout mice (HET) received chronic phencyclidine (PCP) or saline (SAL) treatment for 14 days and an acute treatment of LY379268 or olanzapine after 14 days washout. N-methyl-D-aspartate receptors (NMDA-R) binding was quantified in the prefrontal cortex (PFC), caudate putamen (CPu), Nucleus accumbens (NAcb), whole hippocampus (Hipp) and subregions (CA1), dentate gyrus (DG), lateral septum (LS). Data presented as mean binding density nCi/mg tissue ± standard error of the mean (n = 6), Statistical significance:*P < 0.05, **P < 0.01, ***P < 0.001 as compared to WT(SAL) vehicle

Fig. 2 Acute LY379268 and olanzapine treatment restore GABAA-R binding density levels in several brain regions of two-hit NRG1 HET (PCP) mice. Wild type mice (WT) and neuregulin 1 heterozygous transmembrane domain knockout mice (HET) received chronic phencyclidine (PCP) or saline (SAL) treatment for 14 days and an acute treatment of LY379268 or olanzapine after 14 days washout. Gamma-aminobutyric acid receptor A (GABAA-R) binding was quantified in the prefrontal cortex (PFC), caudate putamen (CPu), Nucleus accumbens (NAcb), whole hippocampus (Hipp) and subregions (CA1), dentate gyrus (DG), lateral septum (LS). Data presented as mean binding density nCi/mg tissue ± standard error of the mean (n = 6), Statistical significance:*P < 0.05, **P < 0.01, ***P < 0.001 as compared to WT(SAL) vehicle

Fig. 3 Acute LY379268 treatment restores positive correlation between NMDA-R and GABAA-R binding levels across brain regions in two-hit NRG1 HET(PCP) mice. Spearman’s correlation plots depicting the relationship between NMDA-R and GABAA-R binding levels across all brain regions, following the different modelling strategies and acute treatment options. Abbreviations: wild type mice (WT), neuregulin 1 heterozygous transmembrane domain knockout mice (NRG1), chronic phencyclidine treatment (PCP), chronic saline treatment (SAL) *P > 0.05, **P > 0.01

Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Martin Engel
    • 1
    • 2
    • 3
    • 4
  • Peta Snikeris
    • 1
    • 2
    • 3
  • Natalie Matosin
    • 1
    • 2
    • 3
  • Kelly Anne Newell
    • 1
    • 2
    • 3
  • Xu-Feng Huang
    • 1
    • 2
    • 3
  • Elisabeth Frank
    • 1
    • 3
  1. 1.Schizophrenia Research InstituteSydneyAustralia
  2. 2.Faculty of Science Medicine and HealthUniversity of WollongongWollongongAustralia
  3. 3.Illawarra Health and Medical Research InstituteUniversity of WollongongWollongongAustralia
  4. 4.School of Biological SciencesUniversity of WollongongWollongongAustralia

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