, Volume 232, Issue 19, pp 3663–3676 | Cite as

Psilocybin-induced spiritual experiences and insightfulness are associated with synchronization of neuronal oscillations

  • Michael Kometer
  • Thomas Pokorny
  • Erich Seifritz
  • Franz X. Volleinweider
Original Investigation



During the last years, considerable progress has been made toward understanding the neuronal basis of consciousness by using sophisticated behavioral tasks, brain-imaging techniques, and various psychoactive drugs. Nevertheless, the neuronal mechanisms underlying some of the most intriguing states of consciousness, including spiritual experiences, remain unknown.


To elucidate state of consciousness-related neuronal mechanisms, human subjects were given psilocybin, a naturally occurring serotonergic agonist and hallucinogen that has been used for centuries to induce spiritual experiences in religious and medical rituals.


In this double-blind, placebo-controlled study, 50 healthy human volunteers received a moderate dose of psilocybin, while high-density electroencephalogram (EEG) recordings were taken during eyes-open and eyes-closed resting states. The current source density and the lagged phase synchronization of neuronal oscillations across distributed brain regions were computed and correlated with psilocybin-induced altered states of consciousness.


Psilocybin decreased the current source density of neuronal oscillations at 1.5–20 Hz within a neural network comprising the anterior and posterior cingulate cortices and the parahippocampal regions. Most intriguingly, the intensity levels of psilocybin-induced spiritual experience and insightfulness correlated with the lagged phase synchronization of delta oscillations (1.5–4 Hz) between the retrosplenial cortex, the parahippocampus, and the lateral orbitofrontal area.


These results provide systematic evidence for the direct association of a specific spatiotemporal neuronal mechanism with spiritual experiences and enhanced insight into life and existence. The identified mechanism may constitute a pathway for modulating mental health, as spiritual experiences can promote sustained well-being and psychological resilience.


Psilocybin Consciousness Spirituality Oscillations Serotonin EEG Resting-State PCC ACC Delta 



This work was supported by the Swiss Neuromatrix Foundation and the Heffter Research Institute. We thank Petra Schäfle for her assistance in recruiting and measuring.

Conflict of interests

Prof. Vollenweider is board member of Heffter Research Institute. None of the author has a conflict of interest with regard to this study.


  1. Alkire MT, Hudetz AG, Tononi G (2008) Consciousness and anesthesia. Science 322:876–880PubMedCentralCrossRefPubMedGoogle Scholar
  2. Babiloni C, Lizio R, Carducci F, Vecchio F, Redolfi A, Marino S, Tedeschi G, Montella P, Guizzaro A, Esposito F (2011) Resting state cortical electroencephalographic rhythms and white matter vascular lesions in subjects with Alzheimer’s disease: an Italian multicenter study. J Alzheimers Dis 26:331–346PubMedGoogle Scholar
  3. Babiloni C, Carducci F, Lizio R, Vecchio F, Baglieri A, Bernardini S, Cavedo E, Bozzao A, Buttinelli C, Esposito F (2013) Resting state cortical electroencephalographic rhythms are related to gray matter volume in subjects with mild cognitive impairment and Alzheimer’s disease. Hum Brain Mapp 34:1427–1446CrossRefPubMedGoogle Scholar
  4. Bar M, Aminoff E (2003) Cortical analysis of visual context. Neuron 38:347–358CrossRefPubMedGoogle Scholar
  5. Bell AJ, Sejnowski TJ (1995) An information-maximization approach to blind separation and blind deconvolution. Neural Comput 7:1129–1159CrossRefPubMedGoogle Scholar
  6. Boly M, Phillips C, Tshibanda L, Vanhaudenhuyse A, Schabus M, Dang-Vu TT, Moonen G, Hustinx R, Maquet P, Laureys S (2008) Intrinsic brain activity in altered states of consciousness: how conscious is the default mode of brain function? Ann N Y Acad Sci 1129:119–129PubMedCentralCrossRefPubMedGoogle Scholar
  7. Brewer JA, Worhunsky PD, Gray JR, Tang Y-Y, Weber J, Kober H (2011) Meditation experience is associated with differences in default mode network activity and connectivity. Proc Natl Acad Sci 108:20254–20259PubMedCentralCrossRefPubMedGoogle Scholar
  8. Busch NA, Dubois J, VanRullen R (2009) The phase of ongoing EEG oscillations predicts visual perception. J Neurosci 29:7869–7876CrossRefPubMedGoogle Scholar
  9. Buschman TJ, Denovellis EL, Diogo C, Bullock D, Miller EK (2012) Synchronous oscillatory neural ensembles for rules in the prefrontal cortex. Neuron 76:838–846PubMedCentralCrossRefPubMedGoogle Scholar
  10. Buzsáki G, Draguhn A (2004) Neuronal oscillations in cortical networks. Science 304:1926–1929CrossRefPubMedGoogle Scholar
  11. Buzsáki G, Anastassiou CA, Koch C (2012) The origin of extracellular fields and currents--EEG, ECoG, LFP and spikes. Nat Rev Neurosci 13:407–420CrossRefPubMedGoogle Scholar
  12. Canuet L, Ishii R, Pascual-Marqui RD, Iwase M, Kurimoto R, Aoki Y, Ikeda S, Takahashi H, Nakahachi T, Takeda M (2011) Resting-state EEG source localization and functional connectivity in schizophrenia-like psychosis of epilepsy. PLoS ONE 6:e27863PubMedCentralCrossRefPubMedGoogle Scholar
  13. Canuet L, Tellado I, Couceiro V, Fraile C, Fernandez-Novoa L, Ishii R, Takeda M, Cacabelos R (2012) Resting-state network disruption and APOE genotype in Alzheimer’s disease: a lagged functional connectivity study. PLoS ONE 7, e46289PubMedCentralCrossRefPubMedGoogle Scholar
  14. Carhart-Harris RL, Erritzoe D, Williams T, Stone JM, Reed LJ, Colasanti A, Tyacke RJ, Leech R, Malizia AL, Murphy K, Hobden P, Evans J, Feilding A, Wise RG, Nutt DJ (2012) Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin. Proc Natl Acad Sci U S A 109:2138–2143PubMedCentralCrossRefPubMedGoogle Scholar
  15. Celada P, Puig MV, Díaz-Mataix L, Artigas F (2008) The hallucinogen DOI reduces low-frequency oscillations in rat prefrontal cortex: reversal by antipsychotic drugs. Biol Psychiatry 64:392–400CrossRefPubMedGoogle Scholar
  16. Ching S, Cimenser A, Purdon PL, Brown EN, Kopell NJ (2010) Thalamocortical model for a propofol-induced alpha-rhythm associated with loss of consciousness. Proc Natl Acad Sci U S A 107:22665–22670PubMedCentralCrossRefPubMedGoogle Scholar
  17. Cott C, Rock A (2008) Phenomenology of N,N-dimethyltryptamine use: a thematic analysis. J Scientific Exploration 22:359–370Google Scholar
  18. Dehaene S, Changeux JP (2011) Experimental and theoretical approaches to conscious processing. Neuron 70:200–227CrossRefPubMedGoogle Scholar
  19. Derogatis L (1994) SCL-90-R: Symptom Checklist-90-R. Administration, scoring and procedures manual. National Computer Systems Inc, MinneapolisGoogle Scholar
  20. Dittrich A (1998) The standardized psychometric assessment of altered states of consciousness (ASCs) in humans. Pharmacopsychiatry 31:80–84CrossRefPubMedGoogle Scholar
  21. Elmer S, Rogenmoser L, Kühnis J, Jäncke L (2015) Bridging the gap between perceptual and cognitive perspectives on absolute pitch. J Neurosci 35:366–371CrossRefPubMedGoogle Scholar
  22. Fahrenfort JJ, Snijders TM, Heinen K, van Gaal S, Scholte HS, Lamme VA (2012) Neuronal integration in visual cortex elevates face category tuning to conscious face perception. Proc Natl Acad Sci U S A 109:21504–21509PubMedCentralCrossRefPubMedGoogle Scholar
  23. Fell J, Axmacher N (2011) The role of phase synchronization in memory processes. Nat Rev Neurosci 12:105–118CrossRefPubMedGoogle Scholar
  24. Foster BL, Kaveh A, Dastjerdi M, Miller KJ, Parvizi J (2013) Human retrosplenial cortex displays transient theta phase locking with medial temporal cortex prior to activation during autobiographical memory retrieval. J Neurosci 33:10439–10446PubMedCentralCrossRefPubMedGoogle Scholar
  25. Goda SA, Piasecka J, Olszewski M, Kasicki S, Hunt MJ (2013) Serotonergic hallucinogens differentially modify gamma and high frequency oscillations in the rat nucleus accumbens. Psychopharmacology (Berl) 228:271–282CrossRefGoogle Scholar
  26. Gouzoulis-Mayfrank E, Schreckenberger M, Sabri O, Arning C, Thelen B, Spitzer M, Kovar KA, Hermle L, Büll U, Sass H (1999) Neurometabolic effects of psilocybin, 3,4-methylenedioxyethylamphetamine (MDE) and d-methamphetamine in healthy volunteers. A double-blind, placebo-controlled PET study with [18F]FDG. Neuropsychopharmacology 20:565–581CrossRefPubMedGoogle Scholar
  27. Griffiths RR, Richards WA, McCann U, Jesse R (2006) Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance. Psychopharmacology (Berl) 187:268–283, discussion 284–292 CrossRefGoogle Scholar
  28. Griffiths R, Richards W, Johnson M, McCann U, Jesse R (2008) Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and spiritual significance 14 months later. J Psychopharmacol 22:621–632PubMedCentralCrossRefPubMedGoogle Scholar
  29. Grob C, S., Bossis A, P., Griffiths R, R. (2013) Use of the classic hallucinogen psilocybin for treatment of existential distress associated with cancer. In: Carr BI, Steel J (eds) Psychological Aspects of Cancer. Springer, USAGoogle Scholar
  30. Grob CS, Danforth AL, Chopra GS, Hagerty M, McKay CR, Halberstadt AL, Greer GR (2011) Pilot study of psilocybin treatment for anxiety in patients with advanced-stage cancer. Arch Gen Psychiatry 68:71–8Google Scholar
  31. Guggisberg AG, Rizk S, Ptak R, Di Pietro M, Saj A, Lazeyras F, Lovblad K-O, Schnider A, Pignat J-M (2014) Two intrinsic coupling types for resting-state integration in the human brain. Brain Topogr 1–12Google Scholar
  32. Gusnard DA, Akbudak E, Shulman GL, Raichle ME (2001) Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function. Proc Natl Acad Sci U S A 98:4259–4264PubMedCentralCrossRefPubMedGoogle Scholar
  33. Haegens S, Nácher V, Luna R, Romo R, Jensen O (2011) α-Oscillations in the monkey sensorimotor network influence discrimination performance by rhythmical inhibition of neuronal spiking. Proc Natl Acad Sci U S A 108:19377–19382PubMedCentralCrossRefPubMedGoogle Scholar
  34. Hanslmayr S, Volberg G, Wimber M, Dalal SS, Greenlee MW (2013) Prestimulus Oscillatory Phase at 7 Hz Gates Cortical Information Flow and Visual Perception. Curr Biol 23(22):2273–8CrossRefPubMedGoogle Scholar
  35. Hilty L, Langer N, Pascual-Marqui R, Boutellier U, Lutz K (2011) Fatigue-induced increase in intracortical communication between mid/anterior insular and motor cortex during cycling exercise. Eur J Neurosci 34:2035–2042CrossRefPubMedGoogle Scholar
  36. Hipp JF, Engel AK, Siegel M (2011) Oscillatory synchronization in large-scale cortical networks predicts perception. Neuron 69:387–396CrossRefPubMedGoogle Scholar
  37. Horacek J, Brunovsky M, Novak T, Skrdlantova L, Klirova M, Bubenikova-Valesova V, Krajca V, Tislerova B, Kopecek M, Spaniel F (2007) Effect of low-frequency rTMS on electromagnetic tomography (LORETA) and regional brain metabolism (PET) in schizophrenia patients with auditory hallucinations. Neuropsychobiology 55:132–142CrossRefPubMedGoogle Scholar
  38. Jatoi MA, Kamel N, Malik AS, Faye I (2014) EEG based brain source localization comparison of sLORETA and eLORETA. Australas Phys Eng Sci Med 37:713–721CrossRefPubMedGoogle Scholar
  39. Klimesch W, Sauseng P, Hanslmayr S (2007) EEG alpha oscillations: the inhibition-timing hypothesis. Brain Res Rev 53:63–88CrossRefPubMedGoogle Scholar
  40. Kometer M, Schmidt A, Bachmann R, Studerus E, Seifritz E, Vollenweider FX (2012) Psilocybin biases facial recognition, goal-directed behavior, and mood state toward positive relative to negative emotions through different serotonergic subreceptors. Biol Psychiatry 72:898–906CrossRefPubMedGoogle Scholar
  41. Kometer M, Schmidt A, Jäncke L, Vollenweider FX (2013) Activation of serotonin 2A receptors underlies the psilocybin-induced effects on α oscillations, N170 visual-evoked potentials, and visual hallucinations. J Neurosci 33:10544–10551CrossRefPubMedGoogle Scholar
  42. Kühnis J, Elmer S, Jäncke L (2014) Auditory evoked responses in musicians during passive vowel listening are modulated by functional connectivity between bilateral auditory-related brain regions. J Cogn Neurosci 26:2750–2761CrossRefPubMedGoogle Scholar
  43. Lee TW, Girolami M, Sejnowski TJ (1999) Independent component analysis using an extended infomax algorithm for mixed subgaussian and supergaussian sources. Neural Comput 11:417–441CrossRefPubMedGoogle Scholar
  44. Levin JS (1993) Age differences in mystical experience. Gerontologist 33:507–513CrossRefPubMedGoogle Scholar
  45. Lu H, Zuo Y, Gu H, Waltz JA, Zhan W, Scholl CA, Rea W, Yang Y, Stein EA (2007) Synchronized delta oscillations correlate with the resting-state functional MRI signal. Proc Natl Acad Sci U S A 104:18265–18269PubMedCentralCrossRefPubMedGoogle Scholar
  46. Maselko J, Kubzansky LD (2006) Gender differences in religious practices, spiritual experiences and health: results from the US General Social Survey. Soc Sci Med 62:2848–2860CrossRefPubMedGoogle Scholar
  47. McClain CS, Rosenfeld B, Breitbart W (2003) Effect of spiritual well-being on end-of-life despair in terminally-ill cancer patients. Lancet 361:1603–1607CrossRefPubMedGoogle Scholar
  48. Melloni L, Molina C, Pena M, Torres D, Singer W, Rodriguez E (2007) Synchronization of neural activity across cortical areas correlates with conscious perception. J Neurosci 27:2858–2865CrossRefPubMedGoogle Scholar
  49. Merker B (2013) Cortical gamma oscillations: the functional key is activation, not cognition. Neurosci Biobehav Rev 37:401–417CrossRefPubMedGoogle Scholar
  50. Miller L, Bansal R, Wickramaratne P, Hao X, Tenke CE, Weissman MM, Peterson BS (2014) Neuroanatomical correlates of religiosity and spirituality: a study in adults at high and low familial risk for depression. JAMA Psychiatry 71:128–135PubMedCentralCrossRefPubMedGoogle Scholar
  51. Mulert C, Jäger L, Schmitt R, Bussfeld P, Pogarell O, Möller HJ, Juckel G, Hegerl U (2004) Integration of fMRI and simultaneous EEG: towards a comprehensive understanding of localization and time-course of brain activity in target detection. Neuroimage 22:83–94CrossRefPubMedGoogle Scholar
  52. Mulert C, Jäger L, Propp S, Karch S, Störmann S, Pogarell O, Möller H-J, Juckel G, Hegerl U (2005) Sound level dependence of the primary auditory cortex: simultaneous measurement with 61-channel EEG and fMRI. Neuroimage 28:49–58CrossRefPubMedGoogle Scholar
  53. Murphy M, Bruno MA, Riedner BA, Boveroux P, Noirhomme Q, Landsness EC, Brichant JF, Phillips C, Massimini M, Laureys S, Tononi G, Boly M (2011) Propofol anesthesia and sleep: a high-density EEG study. Sleep 34:283–291APubMedCentralPubMedGoogle Scholar
  54. Muthukumaraswamy SD, Carhart-Harris RL, Moran RJ, Brookes MJ, Williams TM, Errtizoe D, Sessa B, Papadopoulos A, Bolstridge M, Singh KD, Feilding A, Friston KJ, Nutt DJ (2013) Broadband cortical desynchronization underlies the human psychedelic state. J Neurosci 33:15171–15183CrossRefPubMedGoogle Scholar
  55. Neuner I, Arrubla J, Werner CJ, Hitz K, Boers F, Kawohl W, Shah NJ (2014) The default mode network and EEG regional spectral power: a simultaneous fMRI-EEG study. PLoS ONE 9:e88214PubMedCentralCrossRefPubMedGoogle Scholar
  56. Nichols DE (2004) Hallucinogens. Pharmacol Ther 101:131–181CrossRefPubMedGoogle Scholar
  57. Nichols TE (2012) Multiple testing corrections, nonparametric methods, and random field theory. Neuroimage 62:811–815CrossRefPubMedGoogle Scholar
  58. Nichols TE, Holmes AP (2002) Nonparametric permutation tests for functional neuroimaging: a primer with examples. Hum Brain Mapp 15:1–25CrossRefPubMedGoogle Scholar
  59. Nolte G, Bai O, Wheaton L, Mari Z, Vorbach S, Hallett M (2004) Identifying true brain interaction from EEG data using the imaginary part of coherency. Clin Neurophysiol 115:2292–2307CrossRefPubMedGoogle Scholar
  60. Olbrich S, Mulert C, Karch S, Trenner M, Leicht G, Pogarell O, Hegerl U (2009) EEG-vigilance and BOLD effect during simultaneous EEG/fMRI measurement. Neuroimage 45:319–332CrossRefPubMedGoogle Scholar
  61. Olbrich S, Tränkner A, Chittka T, Hegerl U, Schönknecht P (2014) Functional connectivity in major depression: increased phase synchronization between frontal cortical EEG-source estimates. Psychiatry Res Neuroimaging 222:91–99CrossRefPubMedGoogle Scholar
  62. Pascual-Marqui RD (2002) Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details. Methods Find Exp Clin Pharmacol 24(Suppl D):5–12PubMedGoogle Scholar
  63. Pascual-Marqui RD, Michel CM, Lehmann D (1994) Low resolution electromagnetic tomography: a new method for localizing electrical activity in the brain. Int J Psychophysiol 18:49–65CrossRefPubMedGoogle Scholar
  64. Pascual-Marqui RD, Lehmann D, Koukkou M, Kochi K, Anderer P, Saletu B, Tanaka H, Hirata K, John ER, Prichep L, Biscay-Lirio R, Kinoshita T (2011) Assessing interactions in the brain with exact low-resolution electromagnetic tomography. Philos Trans A Math Phys Eng Sci 369:3768–3784CrossRefPubMedGoogle Scholar
  65. Pascual-Marqui RD, Biscay RJ, Bosch-Bayard J, Lehmann D, Kochi K, Kinoshita T, Yamada N, Sadato N (2014) Assessing direct paths of intracortical causal information flow of oscillatory activity with the isolated effective coherence (iCoh). Front Hum Neurosci 8Google Scholar
  66. Perrin F, Pernier J, Bertrand O, Echallier JF (1989) Spherical splines for scalp potential and current density mapping. Electroencephalogr Clin Neurophysiol 72:184–187CrossRefPubMedGoogle Scholar
  67. Pizzagalli DA, Oakes TR, Fox AS, Chung MK, Larson CL, Abercrombie HC, Schaefer SM, Benca RM, Davidson RJ (2004) Functional but not structural subgenual prefrontal cortex abnormalities in melancholia. Mol Psychiatry 9(325):393–405CrossRefGoogle Scholar
  68. Puig MV, Watakabe A, Ushimaru M, Yamamori T, Kawaguchi Y (2010) Serotonin modulates fast-spiking interneuron and synchronous activity in the rat prefrontal cortex through 5-HT1A and 5-HT2A receptors. J Neurosci 30:2211–2222CrossRefPubMedGoogle Scholar
  69. Ramyead A, Kometer M, Studerus E, Koranyi S, Ittig S, Gschwandtner U, Fuhr P, Riecher-Rössler A (2014) Aberrant current source-density and lagged phase synchronization of neural oscillations as markers for emerging psychosis. Schizophr Bull 41(4):919–929CrossRefPubMedGoogle Scholar
  70. Riba J, Anderer P, Morte A, Urbano G, Jané F, Saletu B, Barbanoj MJ (2002) Topographic pharmaco-EEG mapping of the effects of the South American psychoactive beverage ayahuasca in healthy volunteers. Br J Clin Pharmacol 53:613–628PubMedCentralCrossRefPubMedGoogle Scholar
  71. Riba J, Anderer P, Jané F, Saletu B, Barbanoj MJ (2004) Effects of the South American psychoactive beverage ayahuasca on regional brain electrical activity in humans: a functional neuroimaging study using low-resolution electromagnetic tomography. Neuropsychobiology 50:89–101CrossRefPubMedGoogle Scholar
  72. Schoffelen JM, Gross J (2009) Source connectivity analysis with MEG and EEG. Hum Brain Mapp 30:1857–1865CrossRefPubMedGoogle Scholar
  73. Schroeder CE, Lakatos P (2009) Low-frequency neuronal oscillations as instruments of sensory selection. Trends Neurosci 32:9–18CrossRefPubMedGoogle Scholar
  74. Sheehan D, Lecrubier Y, Sheehan K, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar G (1998) The Mini-International Neuropsychiatric Interview (MINI): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59:22–33PubMedGoogle Scholar
  75. Shushruth S (2013) Exploring the neural basis of consciousness through anesthesia. J Neurosci 33:1757–1758PubMedCentralCrossRefPubMedGoogle Scholar
  76. Siegel M, Donner TH, Engel AK (2012) Spectral fingerprints of large-scale neuronal interactions. Nat Rev Neurosci 13:121–134PubMedGoogle Scholar
  77. Southwick SM, Charney DS (2012) The science of resilience: implications for the prevention and treatment of depression. Science 338:79–82CrossRefPubMedGoogle Scholar
  78. Stam CJ, Nolte G, Daffertshofer A (2007) Phase lag index: assessment of functional connectivity from multi channel EEG and MEG with diminished bias from common sources. Hum Brain Mapp 28:1178–1193CrossRefPubMedGoogle Scholar
  79. Steinmann S, Leicht G, Ertl M, Andreou C, Polomac N, Westerhausen R, Friederici AD, Mulert C (2014) Conscious auditory perception related to long-range synchrony of gamma oscillations. Neuroimage 100:435–443CrossRefPubMedGoogle Scholar
  80. Studerus E, Gamma A, Vollenweider FX (2010) Psychometric evaluation of the altered states of consciousness rating scale (OAV). PLoS ONE 5, e12412PubMedCentralCrossRefPubMedGoogle Scholar
  81. Studerus E, Kometer M, Hasler F, Vollenweider FX (2011) Acute, subacute and long-term subjective effects of psilocybin in healthy humans: a pooled analysis of experimental studies. J Psychopharmacol 25:1434–1452CrossRefPubMedGoogle Scholar
  82. Tenke CE, Kayser J, Miller L, Warner V, Wickramaratne P, Weissman MM, Bruder GE (2013) Neuronal generators of posterior EEG alpha reflect individual differences in prioritizing personal spirituality. Biol Psychol 94:426–432PubMedCentralCrossRefPubMedGoogle Scholar
  83. Thatcher RW, North DM, Biver CJ (2012) Diffusion spectral imaging modules correlate with EEG LORETA neuroimaging modules. Hum Brain Mapp 33:1062–1075CrossRefPubMedGoogle Scholar
  84. Towle VL, Bolaños J, Suarez D, Tan K, Grzeszczuk R, Levin DN, Cakmur R, Frank SA, Spire JP (1993) The spatial location of EEG electrodes: locating the best-fitting sphere relative to cortical anatomy. Electroencephalogr Clin Neurophysiol 86:1–6CrossRefPubMedGoogle Scholar
  85. Urgesi C, Aglioti SM, Skrap M, Fabbro F (2010) The spiritual brain: selective cortical lesions modulate human self-transcendence. Neuron 65:309–319CrossRefPubMedGoogle Scholar
  86. Vann SD, Aggleton JP, Maguire EA (2009) What does the retrosplenial cortex do? Nat Rev Neurosci 10:792–802CrossRefPubMedGoogle Scholar
  87. VanRullen R, Koch C (2003) Is perception discrete or continuous? Trends Cogn Sci 7:207–213CrossRefPubMedGoogle Scholar
  88. Varela F, Lachaux JP, Rodriguez E, Martinerie J (2001) The brainweb: phase synchronization and large-scale integration. Nat Rev Neurosci 2:229–239CrossRefPubMedGoogle Scholar
  89. Vecchio F, Miraglia F, Curcio G, Altavilla R, Scrascia F, Giambattistelli F, Quattrocchi CC, Bramanti P, Vernieri F, Rossini PM (2015) Cortical brain connectivity evaluated by graph theory in dementia: a correlation study between functional and structural data. J Alzheimers Dis 45(3):745–756PubMedGoogle Scholar
  90. Vitacco D, Brandeis D, Pascual-Marqui R, Martin E (2002) Correspondence of event-related potential tomography and functional magnetic resonance imaging during language processing. Hum Brain Mapp 17:4–12CrossRefPubMedGoogle Scholar
  91. Vollenweider FX, Kometer M (2010) The neurobiology of psychedelic drugs: implications for the treatment of mood disorders. Nat Rev Neurosci 11:642–651CrossRefPubMedGoogle Scholar
  92. Vollenweider FX, Leenders KL, Scharfetter C, Maguire P, Stadelmann O, Angst J (1997) Positron emission tomography and fluorodeoxyglucose studies of metabolic hyperfrontality and psychopathology in the psilocybin model of psychosis. Neuropsychopharmacology 16:357–372CrossRefPubMedGoogle Scholar
  93. Vollenweider FX, Vollenweider-Scherpenhuyzen MF, Bäbler A, Vogel H, Hell D (1998) Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action. Neuroreport 9:3897–3902CrossRefPubMedGoogle Scholar
  94. Wallis JD (2007) Orbitofrontal cortex and its contribution to decision-making. Annu Rev Neurosci 30:31–56CrossRefPubMedGoogle Scholar
  95. Wittchen H-U, Pfister H (1997) DIA-X-Interviews: Manual für Screening-Verfahren und Interview. Swets & Zeitlinger, Frankfurt, HesseGoogle Scholar
  96. Womelsdorf T, Schoffelen JM, Oostenveld R, Singer W, Desimone R, Engel AK, Fries P (2007) Modulation of neuronal interactions through neuronal synchronization. Science 316:1609–1612CrossRefPubMedGoogle Scholar
  97. Worrell GA, Lagerlund TD, Sharbrough FW, Brinkmann BH, Busacker NE, Cicora KM, O’Brien TJ (2000) Localization of the epileptic focus by low-resolution electromagnetic tomography in patients with a lesion demonstrated by MRI. Brain Topogr 12:273–282CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Michael Kometer
    • 1
  • Thomas Pokorny
    • 1
  • Erich Seifritz
    • 2
  • Franz X. Volleinweider
    • 1
  1. 1.Neuropsychopharmacology and Brain Imaging Research Unit, Department of Psychiatry, Psychotherapy and PsychosomaticsUniversity Hospital of Psychiatry ZurichZurichSwitzerland
  2. 2.Department of Psychiatry, Psychotherapy and PsychosomaticsUniversity Hospital of Psychiatry ZurichZurichSwitzerland

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