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Psychopharmacology

, Volume 232, Issue 11, pp 1879–1885 | Cite as

Cortical activity differs during nicotine deprivation versus satiation in heavy smokers

  • David E. EvansEmail author
  • Steven K. Sutton
  • Jason A. Oliver
  • David J. Drobes
Original Investigation

Abstract

Rationale

Research suggests that nicotine deprivation among smokers is associated with lesser resting cortical activity (i.e., greater power density in theta and alpha-1 EEG bands and lesser power in beta bands). These changes in cortical activity may be indicative of withdrawal-related cognitive deficits, yet the markers of differences in cortical activity are not well-established.

Objective

The objective of the study was to clarify the EEG frequency bands affected by nicotine deprivation and assess prospective moderators.

Method

One hundred twenty-four heavy smokers visited the laboratory on two occasions following overnight smoking/nicotine deprivation. Prior to collecting 3 min of resting EEG data, participants smoked two very low nicotine cigarettes (<0.05 mg nicotine yield) at one session and two moderate nicotine cigarettes (0.60 mg nicotine yield) at the other.

Results

Theta and alpha-1 band (4–7 and 8–10 Hz) was greater in the very low nicotine (deprivation) relative to higher nicotine (satiation) condition. There were no condition differences in the beta-1 and beta-2 bands (14–20 and 21–30 Hz).

Conclusions

Greater slow wave resting EEG may serve as a reliable marker of decreased cortical activity during smoking deprivation and, in turn, of withdrawal-related deficits in cognitive functioning. This research may inform the development of adjunct strategies for smoking cessation.

Keywords

Abstinence Attention Cognitive control Cortical activation EEG Hemispheric asymmetry Smoking Tobacco Withdrawal 

Notes

Acknowledgments

This study was funded by NIH grants R21 DA027001 (DE) and R21 DA024226 (DD). Additional support was provided by grant 13PRE14660076 from the American Heart Association (JO) and the Biostatistics Core Facility at the H. Lee Moffitt Cancer Center & Research Institute, an NCI designated Comprehensive Cancer Center (P30-CA076292). The authors would like to thank Renee Ornduff, Natasha Garcia, and Lauren Meltzer for their work on the project.

Conflict of interest

None of the authors have potential conflicts of interest (financial or other) regarding the information reported herein. David Drobes has served as an expert witness in litigation against tobacco companies.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • David E. Evans
    • 1
    • 2
    • 3
    Email author
  • Steven K. Sutton
    • 1
    • 2
  • Jason A. Oliver
    • 1
    • 2
  • David J. Drobes
    • 1
    • 2
  1. 1.Moffitt Cancer CenterTampaUSA
  2. 2.University of South FloridaTampaUSA
  3. 3.Department of Health Outcomes and BehaviorH. Lee Moffitt Cancer Center & Research InstituteTampaUSA

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