LSD enhances suggestibility in healthy volunteers
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Lysergic acid diethylamide (LSD) has a history of use as a psychotherapeutic aid in the treatment of mood disorders and addiction, and it was also explored as an enhancer of mind control.
The present study sought to test the effect of LSD on suggestibility in a modern research study.
Ten healthy volunteers were administered with intravenous (i.v.) LSD (40–80 μg) in a within-subject placebo-controlled design. Suggestibility and cued mental imagery were assessed using the Creative Imagination Scale (CIS) and a mental imagery test (MIT). CIS and MIT items were split into two versions (A and B), balanced for ‘efficacy’ (i.e. A≈B) and counterbalanced across conditions (i.e. 50 % completed version ‘A’ under LSD). The MIT and CIS were issued 110 and 140 min, respectively, post-infusion, corresponding with the peak drug effects.
Volunteers gave significantly higher ratings for the CIS (p = 0.018), but not the MIT (p = 0.11), after LSD than placebo. The magnitude of suggestibility enhancement under LSD was positively correlated with trait conscientiousness measured at baseline (p = 0.0005).
These results imply that the influence of suggestion is enhanced by LSD. Enhanced suggestibility under LSD may have implications for its use as an adjunct to psychotherapy, where suggestibility plays a major role. That cued imagery was unaffected by LSD implies that suggestions must be of a sufficient duration and level of detail to be enhanced by the drug. The results also imply that individuals with high trait conscientiousness are especially sensitive to the suggestibility-enhancing effects of LSD.
KeywordsSerotonin Hallucinogens Psychedelics LSD Suggestibility Hypnosis
This research received financial and intellectual support from the Beckley Foundation and was conducted as part of a wider Beckley-Imperial research programme. This report presents independent research carried out at the NIHR/Wellcome Trust Imperial Clinical Research Facility. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. The authors are grateful to Devin Terhune, David Luke and Jamie Ward for advising on the inclusion of the MODTAS and OSIVQ and to Neiloufar Family for her help with managing the research.
- Abramson HA (1967). The use of LSD in psychotherapy and alcoholism. edn. [s.n.]: Indianapolis.Google Scholar
- Barber TX (1995). Hypnosis: a scientific approach. edn. J. Aronson: Northvale, N.J.;; London.Google Scholar
- Carhart-Harris RL, Williams TM, Sessa B, Tyacke RJ, Rich AS et al (2011) The administration of psilocybin to healthy, hallucinogen-experienced volunteers in a mock-functional magnetic resonance imaging environment: a preliminary investigation of tolerability. J Psychopharmacol 25:1562–67PubMedCrossRefGoogle Scholar
- Cohen S (1964) The beyond within; the LSD story, 1st edn. Atheneum, New YorkGoogle Scholar
- Crawford HJ, Knebel T, Vendemia JMC (1998) The nature of hypnotic analgesia: neurophysiological foundation and evidence. Contemporary Hypnosis 15:24–35Google Scholar
- Dienes Z, Hutton S (2013) Understanding hypnosis metacognitively: rTMS applied to left DLPFC increases hypnotic susceptibility. Cortex 49:386–392Google Scholar
- Dienes Z, Brown E, Hutton S, Kirsch I, Mazzoni G, Wright DB (2009) Hypnotic suggestibility, cognitive inhibition, and dissociation. Consciousness and cognition 18(4):837–847Google Scholar
- Gasser P, Holstein D, Michel Y, Doblin R, Yazar-Klosinski B, Passie T, et al. (2014). Safety and efficacy of lysergic acid diethylamide-assisted psychotherapy for anxiety associated with life-threatening diseases. J Nerv Mental Dis 202(7):513–20Google Scholar
- Grof S (1980) LSD Psychotherapy. Hunter House, USGoogle Scholar
- Gudjonsson G (2003) The psychology of interrogations and confessions. Wiley, New YorkGoogle Scholar
- Hilgard ER (1986) Divided consciousness: multiple controls in human thought and action. Am J Psychol 91(3):545–547Google Scholar
- Hofmann A (1980) LSD: my problem child. McGraw-Hill, New YorkGoogle Scholar
- Hull CL (1933). Hypnosis and suggestibility: an experimental approach. edn. Appleton: [S.l.].Google Scholar
- Jamieson G (1987). The structure and meaning of absorption: Phd thesisGoogle Scholar
- Josiah Macy JF, Abramson HA (1960) The Use of LSD in Psychotherapy. Transactions of a conference on d-lysergic acid diethylamide, LSD-25, April 22, 23 and 24, 1959. Princeton, N.J. Edited by Harold A. Abramson. edn. New YorkGoogle Scholar
- Marks J (1979). The search for the “Manchurian candidate”: the CIA and mind control. edn. Norton, 1991: New York;; LondonGoogle Scholar
- Ott U, Reuter M, Hennig J, Vaitl D (2005) Evidence for a common biological basis of the absorption trait, hallucinogen effects, and positive symptoms: epistasis between 5-HT2a and COMT polymorphisms. Am J Med Genet B Neuropsychiatr Genet : Off Publ Int Soc Psychiatr Genet 137B(1):29–32CrossRefGoogle Scholar
- Patterson DR, Jensen MP (2003) Hypnosis and clinical pain. Psychological Bulletin 129(4):495–521Google Scholar
- Roseman L, Leech R, Nutt DJ, Feilding A, Carhart-Harris RL (2014). The effects of psilocybin and MDMA on between-network resting state functional connectivity in healthy volunteers. Front Hum Neurosci 8:204. doi: 10.3389/fnhum.2014.00204
- Sandison RA, Whitelaw JD (1957) Further studies in the therapeutic value of lysergic acid diethylamide in mental illness. J Mental Sci 103(431):332–343Google Scholar
- Semmens-Wheeler R, Dienes Z, Duka T (2013) Alcohol increases hypnotic susceptibility. Consciousness and Cognition 22:1082–1091Google Scholar
- Spanos NP (1986) Hypnotic behaviour: a social-psychological interpretation of amnesia, analgesia, and ‘trance logic’. Behavioural and Brain Sciences 9:449–502Google Scholar
- Stevens J (1987). Storming heaven: LSD and the American dream. edn. Paladin, 1989: LondonGoogle Scholar
- Tagliazucchi E, Carhart-Harris R, Leech R, Nutt D, Chialvo DR (2014). Enhanced repertoire of brain dynamical states during the psychedelic experience. arXiv preprint arXiv:1405.6466Google Scholar
- Turecki G, Briere R, Dewar K, Antonetti T, Lesage AD, Seguin M et al (1999) Prediction of level of serotonin 2A receptor binding by serotonin receptor 2A genetic variation in postmortem brain samples from subjects who did or did not commit suicide. Am J Psychiatry 156(9):1456–1458PubMedGoogle Scholar
- Vaidya VA, Marek GJ, Aghajanian GK, Duman RS (1997) 5-HT2A receptor-mediated regulation of brain-derived neurotrophic factor mRNA in the hippocampus and the neocortex. J Neurosci : Off J Soc Neurosci 17(8):2785–2795Google Scholar
- Vollenweider FX, Leenders KL, Scharfetter C, Maguire P, Stadelmann O, Angst J (1997) Positron emission tomography and fluorodeoxyglucose studies of metabolic hyperfrontality and psychopathology in the psilocybin model of psychosis. Neuropsychopharmacol : Off Publ Am Coll Neuropsychopharmacol 16(5):357–372CrossRefGoogle Scholar
- Weitzenhoffer AM, Hilgard ER (1959) Stanford hypnotic susceptibility scale, for use in research investigations in the field of hypnotic phenomena. Consulting Psychologists, Palo AltoGoogle Scholar
- Woody E, Sadler P (1998) On re-integrating dissociated theories: comment on Kirsch and Lynn. Psychological Bulletin 123:192–197Google Scholar