The beneficial effect of oxytocin on avoidance-related facial emotion recognition depends on early life stress experience
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Previous studies have shown that oxytocin (OXT) enhances social cognitive processes. It has also been demonstrated that OXT does not uniformly facilitate social cognition. The effects of OXT administration strongly depend on the exposure to stressful experiences in early life. Emotional facial recognition is crucial for social cognition. However, no study has yet examined how the effects of OXT on the ability to identify emotional faces are altered by early life stress (ELS) experiences. Given the role of OXT in modulating social motivational processes, we specifically aimed to investigate its effects on the recognition of approach- and avoidance-related facial emotions.
In a double-blind, between-subjects, placebo-controlled design, 82 male participants performed an emotion recognition task with faces taken from the “Karolinska Directed Emotional Faces” set. We clustered the six basic emotions along the dimensions approach (happy, surprise, anger) and avoidance (fear, sadness, disgust). ELS was assessed with the Childhood Trauma Questionnaire (CTQ).
Our results showed that OXT improved the ability to recognize avoidance-related emotional faces as compared to approach-related emotional faces. Whereas the performance for avoidance-related emotions in participants with higher ELS scores was comparable in both OXT and placebo condition, OXT enhanced emotion recognition in participants with lower ELS scores. Independent of OXT administration, we observed increased emotion recognition for avoidance-related faces in participants with high ELS scores.
Our findings suggest that the investigation of OXT on social recognition requires a broad approach that takes ELS experiences as well as motivational processes into account.
KeywordsOxytocin Neuropeptide Facial emotion recognition Early life stress
Conflicts of interest
All authors report no potential conflict of interest or financial interest.
- Bernstein DP, Fink L (1998) Childhood Trauma Questionnaire: a retrospective self-report manual. The Psychological Corporation, San AntonioGoogle Scholar
- Costa PTM (1992) Revised NEO personality inventory and NEO five-factor inventory (Professional Manual). Psychological Assessment Resources, OdessaGoogle Scholar
- Dannlowski U, Stuhrmann A, Beutelmann V, Zwanzger P, Lenzen T, Grotegerd D, Domschke K, Hohoff C, Ohrmann P, Bauer J, Lindner C, Postert C, Konrad C, Arolt V, Heindel W, Suslow T, Kugel H (2012) Limbic scars: long-term consequences of childhood maltreatment revealed by functional and structural magnetic resonance imaging. Biol Psychiatry 71(4):286–293PubMedCrossRefGoogle Scholar
- Judd CM, McClelland GH, Ryan CR (2009) Data analysis: a model comparison approach, 2nd ed. RoutledgeGoogle Scholar
- Lundqvist D, Flykt A, Öhman A (1998) The Karolinska Directed Emotional Faces — KDEF, CD ROM from Department of Clinical Neuroscience, Psychology section, Karolinska Institutet, ISBN 91-630-7164-9Google Scholar
- Maheu FS, Dozier M, Guyer AE, Mandell D, Peloso E, Poeth K, Jenness J, Lau JY, Ackerman JP, Pine DS, Ernst M (2010) A preliminary study of medial temporal lobe function in youths with a history of caregiver deprivation and emotional neglect. Cogn Affect Behav Neurosci 10(1):34–49PubMedCentralPubMedCrossRefGoogle Scholar
- Melis MR, Melis T, Cocco C, Succu S, Sanna F, Pillolla G, Boi A, Ferri GL, Argiolas A (2007) Oxytocin injected into the ventral tegmental area induces penile erection and increases extracellular dopamine in the nucleus accumbens and paraventricular nucleus of the hypothalamus of male rats. Eur J Neurosci 26:1026–1035PubMedCrossRefGoogle Scholar
- Olff M, Frijling JL, Kubzansky LD, Bradley B, Ellenbogen MA, Cardoso C, Bartz JA, Yee JR, van Zuiden M (2013) The role of oxytocin in social bonding, stress regulation and mental health: an update on the moderating effects of context and interindividual differences. Psychoneuroendocrinology 38:1883–1894PubMedCrossRefGoogle Scholar
- Steyer R, Schwenkmezger P, Notz P, Eid M (1997) Der Mehrdimensionale Befindlichkeitsfragebogen (MDBF). Hogrefe-Verlage für Psychologie, GöttingenGoogle Scholar
- Wittchen HU, Wunderlich U, Gruschwitz S, Zaudig M (1997) SKID-I. Strukturiertes Klinisches Interview für DSM-IV. Achse I: Psychische Störungen. Hogrefe, GöttingenGoogle Scholar