Psychopharmacology

, Volume 231, Issue 24, pp 4649–4657

Acute effects of low and high dose alcohol on smoking lapse behavior in a laboratory analogue task

  • Christopher W. Kahler
  • Jane Metrik
  • Nichea S. Spillane
  • Anne Day
  • Adam M. Leventhal
  • Sherry A. McKee
  • Jennifer W. Tidey
  • John E. McGeary
  • Valerie S. Knopik
  • Damaris J. Rohsenow
Original Investigation

Abstract

Rationale

Smoking lapses (i.e., returns to smoking after quitting) often occur following alcohol consumption with observational data suggesting greater quantities of alcohol lead to greater risk. However, a causal dose-dependent effect of alcohol consumption on smoking lapse behavior has not been established, and the mechanisms that might account for such an effect have not been tested.

Objectives

In a within-subjects design, we examined the effects of low- (0.4 g/kg) and high-dose (0.8 g/kg) alcohol, relative to placebo, on smokers’ ability to resist initiating smoking after acute smoking abstinence.

Methods

Participants were 100 heavy alcohol drinkers, smoking 10–30 cigarettes per day. Across three separate days, participants consumed placebo, low-dose, or high-dose alcohol following 3 h of smoking abstinence and, 35 min later, were offered the opportunity to smoke while resisting smoking was monetarily reinforced proportional to the amount of time delayed.

Results

Consistent with a dose–response effect, participants smoked 3.35 min (95 % confidence intervals (CI) [−7.09, 0.40], p = .08) earlier following low-dose alcohol and 6.36 min (95 % CI [−9.99, −2.73], p = .0006) earlier following high-dose alcohol compared to drinking a placebo beverage. Effects of dose on smoking behavior were partially mediated by increases in urge to smoke. There was no evidence that alcohol’s effects on urge to smoke or ability to resist smoking were mediated through its stimulating or sedating effects.

Conclusions

Alcohol can reduce the ability to resist smoking in a dose-dependent fashion, in part, due to its effect on increasing the intensity of smoking urges.

Keywords

Alcohol Smoking relapse Craving Urge to smoke Stimulation Alcohol administration 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Christopher W. Kahler
    • 1
  • Jane Metrik
    • 2
    • 1
  • Nichea S. Spillane
    • 1
  • Anne Day
    • 1
  • Adam M. Leventhal
    • 3
  • Sherry A. McKee
    • 4
  • Jennifer W. Tidey
    • 1
  • John E. McGeary
    • 2
    • 5
    • 6
  • Valerie S. Knopik
    • 5
    • 6
  • Damaris J. Rohsenow
    • 2
    • 1
  1. 1.Center for Alcohol and Addiction StudiesBrown University School of Public HealthProvidenceUSA
  2. 2.Providence VA Medical CenterProvidenceUSA
  3. 3.Departments of Preventive Medicine and PsychologyUniversity of Southern California Keck School of MedicineLos AngelesUSA
  4. 4.Department of PsychiatryYale University School of MedicineNew HavenUSA
  5. 5.Division of Behavioral Genetics, Rhode Island HospitalBrown UniversityProvidenceUSA
  6. 6.Department of Psychiatry and Human Behavior, Alpert Medical SchoolBrown UniversityProvidenceUSA

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