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Psychopharmacology

, Volume 231, Issue 23, pp 4443–4453 | Cite as

Compromised frontocerebellar circuitry contributes to nonplanning impulsivity in recovering alcoholics

  • Young-Chul Jung
  • Tilman Schulte
  • Eva M. Müller-Oehring
  • Kee Namkoong
  • Adolf Pfefferbaum
  • Edith V. Sullivan
Original Investigation

Abstract

Rationale

Degradation of frontocerebellar circuitry is a principal neural mechanism of alcoholism-related executive dysfunctions affecting impulse control and cognitive planning.

Objective

We tested the hypothesis that alcoholic patients would demonstrate compromised dorsal anterior cingulate cortex (dACC) –cerebellar functional connectivity when adjusting their strategies to accommodate uncertain conditions and would recruit compensatory brain regions to overcome ineffective response patterns.

Methods

Twenty-six alcoholics and 26 healthy participants underwent functional MRI in two sequential runs while performing a decision-making task. The first run required a response regardless of level of ambiguity of the stimuli; the second run allowed a PASS option (i.e., no response choice), which was useful on ambiguous trials.

Results

Healthy controls demonstrated strong synchronous activity between the dACC and cerebellum while planning and executing a behavioral strategy. By contrast, alcoholics showed synchronous activity between the dACC and the premotor cortex, perhaps enabling successful compensation for accuracy and reaction time in certain conditions; however, a negative outcome of this strategy was rigidity in modifying response strategy to accommodate uncertain conditions. Compared with the alcoholic group, the control group had lower nonplanning impulsiveness, which correlated with using the option PASS to respond in uncertain conditions.

Conclusion

These findings suggest that compromised dACC–cerebellar functional circuitry contributes to recruitment of an alternative network—dACC–premotor cortex— to perform well under low-risk, unambiguous conditions. This compensatory network, however, was inadequate to enable the alcoholics to avert making poor choices in planning and executing an effective behavioral strategy in high-risk, uncertain conditions.

Keywords

Alcoholism Nonplanning impulsivity Anterior cingulate cortex Cerebellum 

Notes

Acknowledgments

The authors would like to thank William Hawkes for data collection and analysis. This research was supported by NIH grants AA010723, AA012388, AA017168, and AA017923.

Disclosure

The authors declare no conflict of interest.

Supplementary material

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Young-Chul Jung
    • 1
    • 2
    • 4
  • Tilman Schulte
    • 3
  • Eva M. Müller-Oehring
    • 2
    • 3
  • Kee Namkoong
    • 1
    • 4
  • Adolf Pfefferbaum
    • 2
    • 3
  • Edith V. Sullivan
    • 2
  1. 1.Department of PsychiatryYonsei University College of MedicineSeoulSouth Korea
  2. 2.Department of Psychiatry and Behavioral SciencesStanford University School of MedicineStanfordUSA
  3. 3.Neuroscience ProgramSRI InternationalMenlo ParkUSA
  4. 4.Institute of Behavioral Science in MedicineYonsei University College of MedicineSeoulSouth Korea

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