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Psychopharmacology

, Volume 231, Issue 22, pp 4371–4381 | Cite as

Differential regulation of observational fear and neural oscillations by serotonin and dopamine in the mouse anterior cingulate cortex

  • Byung Sun Kim
  • Junghee Lee
  • Minji Bang
  • Bo Am Seo
  • Arshi Khalid
  • Min Whan Jung
  • Daejong Jeon
Original Investigation

Abstract

Rationale

The aberrant regulation of serotonin (5-HT) and dopamine (DA) in the brain has been implicated in neuropsychiatric disorders associated with marked impairments in empathy, such as schizophrenia and autism. Many psychiatric drugs bind to both types of receptors, and the anterior cingulate cortex (ACC) is known to be centrally involved with empathy. However, the relationship between the 5-HT/DA system in the ACC and empathic behavior is not yet well known.

Objectives

We investigated the role of 5-HT/DA in empathy-like behavior and in the regulation of ACC neural activity.

Methods

An observational fear learning task was conducted following microinjections of 5-HT, DA, 5-HT and DA, methysergide (5-HT receptor antagonist), SCH-23390 (DA D1 receptor antagonist), or haloperidol (DA D2 receptor antagonist) into the mouse ACC. The ACC neural activity influenced by 5-HT and DA was electrophysiologically characterized in vitro and in vivo.

Results

The microinjection of haloperidol, but not methysergide or SCH-23390, decreased the fear response of observing mice. The administration of 5-HT and 5-HT and DA together, but not DA alone, reduced the freezing response of observing mice. 5-HT enhanced delta-band activity and reduced alpha- and gamma-band activities in the ACC, whereas DA reduced only alpha-band activity. Based on entropy, reduced complexity of ACC neural activity was observed with 5-HT treatment.

Conclusions

The current results demonstrated that DA D2 receptors in the ACC are required for observational fear learning, whereas increased 5-HT levels disrupt observational fear and alter the regularity of ACC neural oscillations.

Keywords

Serotonin Dopamine Anterior cingulate cortex Empathy Observational fear Neural activity Entropy 

Notes

Acknowledgments

This work was supported by the Korea Health 21 R&D grant (HI12C0035) funded by Ministry of Health and Welfare, and M.W.J was supported by the Research Center Program of the Institute for Basic Science, Korea.

Conflict of interest

The authors report no conflicts of interest.

Supplementary material

213_2014_3581_MOESM1_ESM.pdf (12 kb)
ESM 1 (PDF 11 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Byung Sun Kim
    • 1
  • Junghee Lee
    • 1
  • Minji Bang
    • 1
  • Bo Am Seo
    • 1
  • Arshi Khalid
    • 1
  • Min Whan Jung
    • 2
  • Daejong Jeon
    • 1
  1. 1.Department of Bio and Brain EngineeringKorea Advanced Institute of Science and Technology (KAIST)DaejeonRepublic of Korea
  2. 2.Center for Synaptic Brain Dysfunctions, Institute for Basic Science and Department of Biological SciencesKorea Advanced Institute of Science and Technology (KAIST)DaejeonRepublic of Korea

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