, Volume 231, Issue 22, pp 4271–4279 | Cite as

Effects of acute alcohol tolerance on perceptions of danger and willingness to drive after drinking

  • Michael T. Amlung
  • David H. Morris
  • Denis M. McCarthy
Original Investigation



Drinking and driving is associated with elevated rates of motor vehicle accidents and fatalities. Previous research suggests that alcohol impairs judgments about the dangers of risky behaviors; however, how alcohol affects driving-related judgments is less clear. Impairments have also been shown to differ across limbs of the blood alcohol concentration (BAC) curve, which is known as acute tolerance.


The objectives of this study were to examine whether perceptions about the dangerousness of driving after drinking and willingness to drive differed across the ascending and descending limbs of the BAC curve and to test whether reductions in perceived danger were associated with willingness to drive on the descending limb.


Fifty-six participants were randomly assigned to receive either a moderate dose of alcohol (peak BAC = 0.10 g%) or placebo. We assessed perceived dangerousness and willingness to drive at matched BACs (~0.067–0.068 g%) on the ascending and descending limbs.


Both perceived danger and willingness to drive showed acute tolerance in the alcohol group. Participants judged driving to be significantly less dangerous and were more willing to drive on the descending limb compared to the ascending limb. The magnitude of change in perceived danger significantly predicted willingness to drive on the descending limb.


Decreased impairment associated with acute tolerance may lead individuals to underestimate the dangerousness of driving after drinking and in turn make poor decisions regarding driving. This study further emphasizes the descending limb as a period of increased risk and offers support for enhancing prevention efforts by targeting drivers at declining BAC levels.


Drinking and driving Perceived danger Alcohol administration Acute tolerance Descending limb 



This research was supported by grants (R01 AA019546, T32 AA013526) from the National Institute of Alcohol Abuse and Alcoholism. The authors thank Dr. Chia-Lin Tsai for contributions to data analysis.

Conflict of interest

The authors have no conflicts of interest in conducting this research. This study complies with the laws of the United States of America.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Michael T. Amlung
    • 1
  • David H. Morris
    • 1
  • Denis M. McCarthy
    • 1
  1. 1.Department of Psychological SciencesUniversity of MissouriColumbiaUSA

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