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Psychopharmacology

, Volume 231, Issue 11, pp 2223–2236 | Cite as

A critical analysis of alcohol hangover research methodology for surveys or studies of effects on cognition

  • Richard Stephens
  • James A. Grange
  • Kate Jones
  • Lauren Owen
Review

Abstract

Rationale

Alcohol hangover may be defined as an adverse effect of heavy alcohol consumption present after sufficient time has elapsed for the alcohol to have been eliminated from the blood. Understanding how hangover may impair performance is important for public safety; yet, there is relatively little hangover research. This paper outlines good practice for future studies.

Objectives

This paper presents a critical analysis of hangover methodology for surveys or studies of effects on cognition with human subjects and provides suggestions for optimum research practice for laboratory-based and naturalistic alcohol hangover studies.

Results

Four hangover symptom scales have been developed and subjected to psychometric testing. For retrospective assessment, we recommend the Hangover Symptoms Scale (HSS) or the Alcohol Hangover Severity Scale (AHSS). For concurrent assessment of hangover symptoms, we recommend either the Acute Hangover Scale (AHS), the five-item version of the HSS, or the AHSS. In research aiming to assess the cognitive effects of alcohol hangover, we suggest focusing on the cognitive domains of attention, memory and executive function, and we specify a number of tests within these cognitive domains that are likely to be sensitive to any decrements due to hangover. Finally, we argue that naturalistic studies should assess biological markers to improve the accuracy of estimates of alcohol consumption. Specifically, we recommend the assessment of ethyl glucuronide (EtG) for this purpose.

Conclusions

Recommendations are made with respect to assessing hangover symptoms, cognitive effects of hangover and biological markers of alcohol consumption.

Keywords

Review Alcohol hangover Symptoms Cognitive performance Biological markers Ethyl glucuronide 

Notes

Acknowledgment

This research was supported by EU 7th Framework Marie Curie Research Fellowship Project No: 301424.

References

  1. Anderson S, Dawson J (1999) Neuropsychological correlates of alcoholic hangover. S Afr J Sci 95:145–147Google Scholar
  2. Baddeley A (2012) Working memory: theories models and controversies. Annu Rev Psychol 63:1–29PubMedCrossRefGoogle Scholar
  3. Baker EL, Letz RE, Fidler AT, Stuart S, Plantamura D, Lyndon M (1985) A computer-based neurobehavioral evaluation system for occupational and environmental pidemiology: methodology and validation studies. Neurotoxicol Teratol 7:369–377Google Scholar
  4. Berry CJ, Shanks DR, Henson RN (2008) A unitary signal-detection model of implicit and explicit memory. Trends Cogn Sci 12:367–373PubMedCrossRefGoogle Scholar
  5. Brown SW (2006) Timing and executive function: bidirectional interference between concurrent temporal production and randomization tasks. Mem Cogn 34:1464–1471CrossRefGoogle Scholar
  6. Chait LD, Perry JL (1994) Acute and residual effects of alcohol and marijuana alone and in combination on mood and performance. Psychopharmacology 115:340–349PubMedCrossRefGoogle Scholar
  7. Collins WE, Schroeder DJ, Gilson RD, Guedry FE (1971) Effects of alcohol ingestion on tracking performance during angular acceleration. J Appl Psychol 55:559–563PubMedCrossRefGoogle Scholar
  8. Collins WE, Chiles WD (1980) Laboratory performance during acute intoxication and hangover. Hum Factors 22:445–462PubMedGoogle Scholar
  9. Conway ARA, Kane MJ, Bunting MF, Hambrick DZ, Wilhelm O, Engle RW (2005) Working memory span tasks: A methodological review and user’s guide. Psychon Bull Rev 12:769–786PubMedCrossRefGoogle Scholar
  10. Coulthard E, Singh-Curry V, Husain M (2006) Treatment of attention deficits in neurological disorders. Curr Opin Neurol 19:613–618PubMedCrossRefGoogle Scholar
  11. Dahl H, Stephanson N, Beck O, Helander A (2002) Comparison of urinary excretion characteristics of ethanol and ethyl glucuronide. J Anal Toxicol 26:201–204PubMedCrossRefGoogle Scholar
  12. Droenner P, Schmitt G, Aderjan R, Zimmer HA (2002) Kinetic model describing the pharmacokinetics of ethyl glucuronide in humans. Forensic Sci Int 28:24–29CrossRefGoogle Scholar
  13. Eriksen BA, Eriksen CW (1974) Effects of noise letters upon identification of a target letter in a non-search task. Percept Psychophys 16:143–149CrossRefGoogle Scholar
  14. Farrell S, Lewandowsky S (2010) Computational models as aids to better reasoning in psychology. Curr Dir Psychol Sci 19:329–335CrossRefGoogle Scholar
  15. Finnigan F, Hammersley R (1992) The effects of alcohol on performance. In: Smith AP, Jones DM (eds) Handbook of human performance. Academic, London, pp 73–126Google Scholar
  16. Finnigan F, Hammersley R, Cooper T (1998) An examination of next-day hangover effects after a 100mg/100ml dose of alcohol in heavy social drinkers. Addiction 93:1829–1838PubMedCrossRefGoogle Scholar
  17. Finnigan F, Schulze D, Smallwood J, Helander A (2005) The effects of self-administered alcohol-induced ‘hangover’ in a naturalistic setting on psychomotor and cognitive performance and subjective state. Addiction 100:1680–1689PubMedCrossRefGoogle Scholar
  18. Fisk AD, Scerbo MW (1987) Automatic and control processing approach to interpreting vigilance performance: a review and reevaluation. Hum Factors 29:653–660PubMedGoogle Scholar
  19. Goll M, Schmitt G, Ganssmann B, Aderjan RE (2002) Excretion profiles of ethyl glucuronide in human urine after internal dilution. J Anal Toxicol 26:262–266PubMedCrossRefGoogle Scholar
  20. Grange JA, Houghton G (in press) Task switching and cognitive control New York NY: Oxford University Press.Google Scholar
  21. Halter CC, Dresen S, Auwaerter V, Wurst FM, Weinmann W (2008) Kinetics in serum and urinary excretion of ethyl sulfate and ethyl glucuronide after medium dose ethanol intake. Int J Legal Med 122:123–128PubMedCrossRefGoogle Scholar
  22. Heffernan T, Clark R, Bartholomew J, Ling J, Stephens R (2010) Does binge drinking in teenagers affect their everyday prospective memory? Drug Alcohol Depend 109:73–78PubMedCrossRefGoogle Scholar
  23. Høiseth G, Bernard JP, Stephanson N, Normann PT, Christophersen AS, Mørland J, Helander A (2008) Comparison between the urinary alcohol markers EtG EtS and GTOL/5-HIAA in a controlled drinking experiment. Alcohol Alcohol 43:187–191PubMedCrossRefGoogle Scholar
  24. Høiseth G, Yttredal B, Karinen R, Gjerde H, Mørland J, Christophersen AS (2010) A Ethyl glucuronide concentrations in oral fluid blood and urine after volunteers drank 05 and 10 g/kg doses of ethanol. J Anal Toxicol 34:319–324PubMedCrossRefGoogle Scholar
  25. Howland J, Rohsenow DJ, Edwards EM (2008) Are some drinkers resistant to hangover? A literature review. Curr Drug Abuse Rev 1:42–46PubMedCrossRefGoogle Scholar
  26. Howland J, Rohsenow DJ, Greece JA, Littlefield CA, Almeida A (2010) The effects of binge drinking on college students’ next-day academic test-taking performance and mood state. Addiction 105:655–665PubMedCentralPubMedCrossRefGoogle Scholar
  27. Jaeggi SM, Buschkuehl M, Perrig WJ, Meier B (2010) The concurrent validity of the N-back task as a working memory measure. Memory 18:394–412PubMedCrossRefGoogle Scholar
  28. Jones K, Harrison Y (2001) Frontal lobe function, sleep loss and fragmented sleep. Sleep Med Rev 5:463–475PubMedCrossRefGoogle Scholar
  29. Kiesel A, Steinhauser M, Wendt M, Falkstein M, Jost K, Philipp A, Koch I (2010) Control and interference in task switching—a review. Psychol Bull 136:849–874PubMedCrossRefGoogle Scholar
  30. Kruisselbrink LD, Martin KL, Megeney M (2006) Physical and psychomotor functioning of females the morning after consuming low to moderate quantities of beer. J Stud Alcohol 67:416–420PubMedGoogle Scholar
  31. Laurell H, Törnros J (1983) Investigation of alcoholic hangover effects on driving performance. Blutalkohol 20:489–499Google Scholar
  32. Lemon J, Chester G, Fox A, Greeley J, Nabke C (1993) Investigation of the “hangover” effects of an acute dose of alcohol on psychomotor performance. Alcohol Clin Exp Res 17:665–668PubMedCrossRefGoogle Scholar
  33. Lewis SS, Hutchinson MR, Zhang Y, Hund DK, Maier SF, Rice KC, Watkins LR (2013) Glucuronic acid and the ethanol metabolite ethyl-glucuronide cause toll-like receptor 4 activation and enhanced pain. Brain Behav Immun 30:24–32PubMedCentralPubMedCrossRefGoogle Scholar
  34. Ling J, Stephens R, Heffernan TM (2010) Cognitive and psychomotor performance during alcohol hangover. Curr Drug Abuse Rev 3:80–87PubMedCrossRefGoogle Scholar
  35. Logan GD, Cowan WB (1984) On the ability to inhibit thought and action: a theory of an act of control. Psychol Rev 91:295–327CrossRefGoogle Scholar
  36. MacLeod CM (1991) Half a century of research on the Stroop effect: an integrative review. Psychol Bull 109:163–203PubMedCrossRefGoogle Scholar
  37. McKinney A, Coyle K (2007) Next-day effects of alcohol and an additional stressor on memory and psychomotor performance. J Stud Alcohol 68:446–454Google Scholar
  38. McKinney A, Coyle K (2004) Next day effects of a normal night’s drinking on memory and psychomotor performance. Alcohol Alcohol 39:509–513PubMedCrossRefGoogle Scholar
  39. McKinney A, Coyle K, Penning R, Verster JC (2012) Next day effects of naturalistic alcohol consumption on tasks of attention. Human Psychopharmacol-Clin Exp 27:587–594CrossRefGoogle Scholar
  40. Miyake A, Friedman NP, Emerson MJ, Witzki AH, Howerter A, Wager TD (2000) The unity and diversity of executive functions and their contributions to complex “frontal lobe” tasks: a latent variable analysis. Cogn Psychol 41:49–100PubMedCrossRefGoogle Scholar
  41. Norman DA, Shallice T (1986) Attention to action: willed and automatic control of behavior. In: Davidson RJ, Schwartz GE, Shapiro D (eds) Consciousness and self-regulation: advances in research and theory vol 4. Plenum, New YorkGoogle Scholar
  42. Penning R, van Nuland M, Fliervoet LAL, Olivier B, Verster JC (2010) The pathology of alcohol hangover. Curr Drug Abuse Rev 3:68–75PubMedCrossRefGoogle Scholar
  43. Penning R, McKinney A, Bus LS, Olivier B, Slot K, Verster JC (2013) Measurement of alcohol hangover severity: development of the Alcohol Hangover Severity Scale (AHSS). Psychopharmacology 225:803–810PubMedCrossRefGoogle Scholar
  44. Perry RJ, Hodges JR (1999) Attention and executive deficits in Alzheimer’s disease. Crit Rev Brain 122:383–404Google Scholar
  45. Piasecki TM, Slutske WS, Wood PK, Hunt-Carter EE (2010) Frequency and correlates of diary-measured hangoverlike experiences in a college sample. Psychol Addict Behav 24:163–169Google Scholar
  46. Posner MI, Petersen SE (1990) The attention system of the human brain. Annu Rev Neurosci 13:25–42PubMedCrossRefGoogle Scholar
  47. Prat G, Adan A, Pérez-Pàmies M, Sànchez-Turet M (2008) Neurocognitive effects of alcohol hangover. Addict Behav 33:15–23PubMedCrossRefGoogle Scholar
  48. Robertson BM, Piasecki TM, Slutske WS, Wood PK, Sher KJ, Shiffman S, Heath AC (2012) Validity of the hangover symptoms scale: evidence from an electronic diary study. Alcohol Clin Exp Res 36:171–177PubMedCentralPubMedCrossRefGoogle Scholar
  49. Roehrs T, Yoon J, Roth T (1991) Nocturnal and next-day effects of ethanol and basal level of sleepiness. Hum Psychopharmacol 6:307–311CrossRefGoogle Scholar
  50. Rohsenow DJ, Howland J, Arnedt JT, Almeida AB, Greece J, Minsky S, Kempler CS, Sales S (2010) Intoxication with bourbon versus vodka: effects on hangover sleep and next-day neurocognitive performance in young adults. Alcohol Clin Exp Res 34:1–10CrossRefGoogle Scholar
  51. Rohsenow DJ, Howland J, Minsky S, Greece J, Almeida A, Roehrs TA (2007) The acute hangover scale: a new measure of immediate hangover symptoms. Addict Behav 32:1314–1320PubMedCentralPubMedCrossRefGoogle Scholar
  52. Rohsenow DJ, Howland J, Minsky S, Arnedt JT (2006) Effects of heavy drinking by maritime academy cadets on hangover perceived sleep and next-day ship power plant operation. J Stud Alcohol 67:406–415PubMedGoogle Scholar
  53. Rosvold HE, Mirsky AF, Sarason I, Bransome ED Jr, Beck LH (1956) A continuous performance test of brain damage. J Consult Psychol 20:343–350PubMedCrossRefGoogle Scholar
  54. Rutherford A, Markopoulos G, Bruno D, Brady-Van-den-Bos M (2012) Long-term memory: encoding to retrieval. In: Braisby N, Gellatly A (eds) Cognitive psychology . Oxford University Press, OxfordGoogle Scholar
  55. Schacter DL (1987) Implicit memory: history and current status. J Exp Psychol 3:501–518Google Scholar
  56. Sjøgren MD, Thomsen AN, Olsen AK (2000) Impaired neuropsychological performance in chronic nonmalignant pain patients receiving long-term oral opioid therapy. J Pain Symptom Manag 19:100–108CrossRefGoogle Scholar
  57. Slutske WS, Piasecki TM, Hunt-Carter EE (2003) Development and initial validation of the hangover symptoms scale: prevalence and correlates of hangover in college students. Alcohol Clin Exp Res 27:1442–1450PubMedCrossRefGoogle Scholar
  58. Squire LR (1992) Declarative and nondeclarative memory: multiple brain systems supporting learning and memory. J Cogn Neurosci 4:232–243PubMedCrossRefGoogle Scholar
  59. Stephens R, Ling J, Heffernan TM, Heather N, Jones K (2008) A review of the literature on the cognitive effects of the alcohol hangover. Alcohol Alcohol 43:163–170PubMedCrossRefGoogle Scholar
  60. Streufert S, Pogash R, Braig D, Gingrich D, Kantner A, Landis R, Lonardi L, Roache J, Severs W (1995) Alcohol hangover and managerial effectiveness. Alcohol Clin Exp Res 19:1141–1146PubMedCrossRefGoogle Scholar
  61. Süß HM, Oberauer K, Wittmann WW, Wilhelm O, Schulze R (2002) Working-memory capacity explains reasoning ability-and a little bit more. Intelligence 30:261–288CrossRefGoogle Scholar
  62. Swift R, Davidson D (1998) Alcohol hangover: mechanisms and mediators. Alcohol Health Res World 22:54–60PubMedGoogle Scholar
  63. Taylor JL, Dolhert N, Friedman L, Mementhaler M, Yesavage JA (1996) Alcohol elimination and simulator performance of male and female aviators: a preliminary report. Aviat Space Environ Med 67:407–413PubMedGoogle Scholar
  64. Törnros J, Laurell H (1991) Acute and hang-over effects of alcohol on simulated driving performance. Blutalkohol 28:24–30PubMedGoogle Scholar
  65. Turgay A, Binder C, Snyder R, Fisman S (2003) Long-term safety and efficacy of risperidone for the treatment of disruptive behavior disorders in children with subaverage IQs. Pediatrics 110:97–109Google Scholar
  66. Vandierendonck A, Liefooghe B, Verbruggen F (2010) Task switching: interplay of reconfiguration and interference control. Psychol Bull 136:601–626PubMedCrossRefGoogle Scholar
  67. Verbruggen F, Logan GD (2008) Response inhibition in the stop-signal paradigm. Trends Cogn Sci 12:418–424PubMedCentralPubMedCrossRefGoogle Scholar
  68. Verbruggen F, Logan GD (2009) Models of response inhibition in the stop-signal and stop-change paradigms. Neurosci Biobehav Rev 33:647–661PubMedCentralPubMedCrossRefGoogle Scholar
  69. Verbruggen F, Chambers CD, Logan GD (2013) Fictitious inhibitory differences: how skewness and slowing distort the estimation of stopping latencies. Psychol Sci 24:352–362PubMedCentralPubMedCrossRefGoogle Scholar
  70. Verster JC (2008) The alcohol hangover—a puzzling phenomenon. Alcohol Alcohol 43:124–126PubMedCrossRefGoogle Scholar
  71. Verster JC, Stephens R, Penning R et al (2010) The alcohol hangover research group consensus statement on best practice in alcohol hangover research. Curr Drug Abuse Rev 3:116–126PubMedCentralPubMedCrossRefGoogle Scholar
  72. Verster JC, van Duin D, Volkerts ER, Schreuder AHCML, Verbaten MN (2003) Alcohol hangover effects on memory functioning and vigilance performance after an evening of binge drinking. Neuropsychopharmacology 28:740–746PubMedCrossRefGoogle Scholar
  73. Wiese JG, Shlipak MG, Browner WS (2000) The alcohol hangover. Ann Intern Med 132:897–902PubMedCrossRefGoogle Scholar
  74. Yesavage A, Leirer VO (1986) Hangover effects of aircraft pilots 14 h after alcohol ingestion: a preliminary report. Am J Psychiatry 143:1546–1550PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Richard Stephens
    • 1
  • James A. Grange
    • 1
  • Kate Jones
    • 2
  • Lauren Owen
    • 1
  1. 1.Centre for Psychological ResearchKeele UniversityStaffordshireUK
  2. 2.Health and Safety LaboratoryDerbyshireUK

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