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Psychopharmacology

, Volume 231, Issue 19, pp 3899–3905 | Cite as

MDMA effects consistent across laboratories

  • Matthew G. Kirkpatrick
  • Matthew J. Baggott
  • John E. Mendelson
  • Gantt P. Galloway
  • Matthias E. Liechti
  • Cédric M. Hysek
  • Harriet de WitEmail author
Original Investigation

Abstract

Rationale

Several laboratories have conducted placebo-controlled drug challenge studies with 3,4-methylenedioxymethamphetamine (MDMA), providing a unique source of data to examine the reliability of the acute effects of the drug across subject samples and settings. We examined the subjective and physiological responses to the drug across three different laboratories and investigated the influence of prior MDMA use.

Methods

Overall, 220 healthy volunteers with varying levels of previous MDMA experience participated in laboratory-based studies in which they received placebo or MDMA orally (1.5 mg/kg or 125-mg fixed dose) under double-blind conditions. Cardiovascular and subjective effects were assessed before and repeatedly after drug administration. The studies were conducted independently by investigators in Basel, San Francisco, and Chicago.

Results

Despite methodological differences between the studies and differences in the subjects’ drug use histories, MDMA produced very similar cardiovascular and subjective effects across the sites. The participants’ prior use of MDMA was inversely related to feeling “Any Drug Effect” only at sites testing more experienced users.

Conclusions

These data indicate that the pharmacological effects of MDMA are robust and highly reproducible across settings. There was also modest evidence for tolerance to the effects of MDMA in regular users.

Keywords

MDMA Tolerance Mood Humans 

Notes

Acknowledgments

This research was supported by DA02812 and DA026570 (Chicago: Harriet de Wit PI), DA017716 and DA016776 (SF: John E. Mendelson PI), and SNSF320030_138481 and SNFF32323B_144996 (Basel: Matthias E. Liechti PI).

Conflict of interest

The authors declare no conflicts of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Matthew G. Kirkpatrick
    • 1
  • Matthew J. Baggott
    • 1
    • 2
  • John E. Mendelson
    • 2
  • Gantt P. Galloway
    • 2
  • Matthias E. Liechti
    • 3
  • Cédric M. Hysek
    • 3
  • Harriet de Wit
    • 1
    Email author
  1. 1.Department of Psychiatry and Behavioral NeuroscienceUniversity of ChicagoChicagoUSA
  2. 2.Addiction & Pharmacology Research LaboratoryCalifornia Pacific Medical CenterSan FranciscoUSA
  3. 3.Division of Clinical Pharmacology and ToxicologyUniversity Hospital and University of BaselBaselSwitzerland

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