Effects of the 5-HT2C receptor agonist meta-chlorophenylpiperazine on appetite, food intake and emotional processing in healthy volunteers
- 442 Downloads
The treatment of obesity is an increasing global health priority, yet few effective drug treatments are currently available. The discovery of novel anti-obesity therapies could be assisted by the validation of experimental (translational) medicine models in healthy volunteers that assess efficacy and safety at an early stage of drug development.
The aim of this study was to examine the effects of the 5-HT2C receptor agonist meta-chlorophenylpiperazine (mCPP) in an experimental medicine model assessing both appetite and mood.
Using a between-subjects, double-blind, placebo-controlled design, 24 male and 24 female participants were randomly assigned to either placebo, 15- or 30-mg mCPP treatment groups. Lunch was eaten from a Universal Eating Monitor (UEM) that measured eating rate, and the participants completed the P1vital® Oxford Emotional Test Battery (ETB) and a series of appetite and mood ratings.
mCPP reduced appetite and, in women, enhanced measures of satiation. The drug also enhanced memory for emotional material in the word recall and recognition memory tasks of the ETB.
The results provide new insight into the effects of mCPP on appetite, satiety and memory in humans. In addition, our data provide an illustration of the value of measuring changes in appetite and mood in healthy volunteers to determine the potential efficacy and safety of novel anti-obesity drugs.
KeywordsExperimental medicine Anti-obesity drugs mCPP 5-HT2C ETB UEM Appetite Food intake Satiation quotient Emotional processing Memory
The research was carried out at the National Institute for Health Research (NIHR)/Wellcome Trust Birmingham Clinical Research Facility. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health. The authors would like to thank the staff at the facility for their support during the study. This work was funded by P1vital and the BBSRC1
Conflicts of interest
Dr Colin Dourish is an employee and shareholder of P1vital Ltd., Dr Suzanne Higgs is a member of P1vital's Advisory Panel, and Jason Michael Thomas is funded by the Steve Cooper P1vital—BBSRC PhD Studentship.
- AMA (2013) AMA adopts new policies on second day of voting at annual meeting. http://www.ama-assn.org/ama/pub/news/news/2013/2013-06-18-new-ama-policies-annual-meeting.page
- Davidson MH, Hauptman J, DiGirolamo M, Foreyt JP, Halsted CH, Heber D, Heimburger DC, Lucas CP, Robbins DC, Chung J, Heymsfield SB (1999) Weight control and risk factor reduction in obese subjects treated for 2 years with orlistat: a randomized controlled trial. JAMA 281:235–242PubMedCrossRefGoogle Scholar
- Dourish CT, Wilding JPH, Halford JCG (2008) Anti-obesity drugs: from animal models to clinical efficacy. In: McArthur RA, Borsini F (eds) Animal and translational models for CNS drug discovery. Vol 3–Reward deficit disorders. Academic, New York, 271–315Google Scholar
- Ekman P, Friesen WV (1976) Pictures of facial affect. Consulting Psychologists Press, Palo AltoGoogle Scholar
- Eysenck HJ, Eysenck SBG (1975) Manual of the Eysenck personality questionnaire (adult and junior). Hodder, LondonGoogle Scholar
- Finucane MM, Stevens GA, Cowan MJ, Danaei G, Lin JK, Paciorek CJ, Singh GM, Gutierrez HR, Lu Y, Bahalim AN, Farzadfar F, Riley LM, Ezzati M (2011) National, regional, and globaltrends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1million participants. Lancet 377:557–567PubMedCrossRefGoogle Scholar
- Matsumoto D, Ekman P (1988) Japanese and Caucasian facial expressions of emotion (JACFEE). Intercultural and Emotion Research Laboratory. Department of Psychology, San Francisco State University, San FranciscoGoogle Scholar
- Nelson HE (1982) The National Adult Reading Test (NART): test manual. NFER-NelsonGoogle Scholar
- Sassi F (2010) Obesity and the economics of prevention: fit not fat. http://www.oecd.org/document/31/0,3343,en_2649_33929_45999775_1_1_1_1,00.html. Accessed 11 Aug 2012
- Smith KA, Oldman AD, Goodall EM, Walsh AES, Williams C, Odontiadis J, Cowen PJ (1994) Effects of meta-chlorophenylpiperazine on neuroendocrine responses and food intake in healthy female volunteers. J Serotonin Res 1:127–132Google Scholar
- Spielberger CD (1983) Manual for the state-trait anxiety inventory. Consulting Psychologists Publishing, Palo AltoGoogle Scholar
- Spitzer RL, Williams JB, Gibbon M, First MB (2004) Structured clinical interview for the DSM-IV (SCID-I/P)Google Scholar
- WHO (2012) Obesity and overweight, Fact sheet N°311. World Health Organization. http://www.who.int/mediacentre/factsheets/fs311/en/index.html Accessed 11 Aug 2012