Neural responses to subliminally presented cannabis and other emotionally evocative cues in cannabis-dependent individuals
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Addiction theories posit that drug-related cues maintain and contribute to drug use and relapse. Indeed, our recent study in cocaine-dependent patients demonstrated that subliminally presented cocaine-related stimuli activate reward neurocircuitry without being consciously perceived. Activation of reward neurocircuitry may provoke craving and perhaps prime an individual for subsequent drug-seeking behaviors.
Using an equivalent paradigm, we tested whether cannabis cues activate reward neurocircuitry in treatment-seeking, cannabis-dependent individuals and whether activation was associated with relevant behavioral anchors: baseline cannabis craving (drug-seeking behavior) and duration of use (degree of conditioning).
Twenty treatment-seeking, cannabis-dependent individuals (12 males) underwent event-related blood oxygen level-dependent functional magnetic resonance imaging during exposure to 33-ms cannabis, sexual, and aversive cues presented in a backward-masking paradigm. Drug use history and cannabis craving were assessed prior to imaging.
Participants showed increased activity to backward-masked cannabis cues in regions supporting reward detection and interoception, including the left anterior insula, left ventral striatum/amygdala, and right ventral striatum. Cannabis cue-related activity in the bilateral insula and perigenual anterior cingulate cortex was positively associated with baseline cannabis craving, and cannabis cue-related activity in the medial orbitofrontal cortex was positively correlated with years of cannabis use. Neural responses to backward-masked sexual cues were similar to those observed during cannabis cue exposure, while activation to aversive cues was observed only in the left anterior insula and perigenual anterior cingulate cortex.
These data highlight the sensitivity of the brain to subliminal reward signals and support hypotheses promoting a common pathway of appetitive motivation.
KeywordsAddiction Cannabis cues Neuroimaging Cannabis craving Subliminal Marijuana cues Marijuana craving Reward
- American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV). American Psychiatric Association, Washington, DCGoogle Scholar
- Brooks SJ, Savov V, Allzen E, Benedict C, Fredriksson R, Schioth HB (2012) Exposure to subliminal arousing stimuli induces robust activation in the amygdala, hippocampus, anterior cingulate, insular cortex and primary visual cortex: a systematic meta-analysis of fMRI studies. Neuroimage 59:2962–2973PubMedCrossRefGoogle Scholar
- Carroll KM (1998) A cognitive-behavioral approach: treating cocaine addiction (NIH publication 98–4308). National Institute on Drug Abuse, Rockville, MDGoogle Scholar
- Diekhof EK, Kaps L, Falkai P, Gruber O (2012) The role of the human ventral striatum and the medial orbitofrontal cortex in the representation of reward magnitude—an activation likelihood estimation meta-analysis of neuroimaging studies of passive reward expectancy and outcome processing. Neuropsychologia 50:1252–1266PubMedCrossRefGoogle Scholar
- Lang P, Bradley M, Cuthbert B (2008) International affective picture system (IAPS): affective ratings of pictures and instruction manual. Technical report A-8. University of Florida, Gainesville, FLGoogle Scholar
- Sobell LC, Sobell MB (1991) Timeline followback: a technique for assessing self-reported alcohol consumption. Humana, TotowaGoogle Scholar
- Substance Abuse and Mental Health Services Administration (2012) Results from the 2011 National Survey on Drug Use and Health: summary of national findings. NSDUH series H-44, HHS publication no. (SMA) 12–4713. Substance Abuse and Mental Health Services Administration, Rockville, MDGoogle Scholar