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Psychopharmacology

, Volume 231, Issue 4, pp 737–751 | Cite as

Depression, impulsiveness, sleep, and memory in past and present polydrug users of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy)

  • Lynn TaurahEmail author
  • Chris Chandler
  • Geoff Sanders
Original Investigation

Abstract

Rationale

Ecstasy (3,4-methylenedioxymethamphetamine, MDMA) is a worldwide recreational drug of abuse. Unfortunately, the results from human research investigating its psychological effects have been inconsistent.

Objectives

The present study aimed to be the largest to date in sample size and 5HT-related behaviors; the first to compare present ecstasy users with past users after an abstinence of 4 or more years, and the first to include robust controls for other recreational substances.

Methods

A sample of 997 participants (52 % male) was recruited to four control groups (non-drug (ND), alcohol/nicotine (AN), cannabis/alcohol/nicotine (CAN), non-ecstasy polydrug (PD)), and two ecstasy polydrug groups (present (MDMA) and past users (EX-MDMA). Participants completed a drug history questionnaire, Beck Depression Inventory, Barratt Impulsiveness Scale, Pittsburgh Sleep Quality Index, and Wechsler Memory Scale-Revised which, in total, provided 13 psychometric measures.

Results

While the CAN and PD groups tended to record greater deficits than the non-drug controls, the MDMA and EX-MDMA groups recorded greater deficits than all the control groups on ten of the 13 psychometric measures. Strikingly, despite prolonged abstinence (mean, 4.98; range, 4–9 years), past ecstasy users showed few signs of recovery. Compared with present ecstasy users, the past users showed no change for ten measures, increased impairment for two measures, and improvement on just one measure.

Conclusions

Given this record of impaired memory and clinically significant levels of depression, impulsiveness, and sleep disturbance, the prognosis for the current generation of ecstasy users is a major cause for concern.

Keywords

MDMA Ecstasy Present users Past users Prolonged abstinence Depression Impulsiveness Sleep Memory Long-lasting deficits 

Notes

Acknowledgments

The authors declare no conflict of interest and no sources of external funding. The study formed part of a PhD thesis submitted by LT and supervised by CC and GS.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.School of PsychologyLondon Metropolitan UniversityLondonUK
  2. 2.School of Psychology, Faculty of Life Sciences and ComputingLondon Metropolitan UniversityLondonUK

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