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Psychopharmacology

, Volume 231, Issue 1, pp 135–141 | Cite as

Dopaminergic stimulation increases selfish behavior in the absence of punishment threat

  • Andreas Pedroni
  • Christoph Eisenegger
  • Matthias N. Hartmann
  • Urs Fischbacher
  • Daria Knoch
Original Investigation

Abstract

Rationale

People often face decisions that pit self-interested behavior aimed at maximizing personal reward against normative behavior such as acting cooperatively, which benefits others. The threat of social sanctions for defying the fairness norm prevents people from behaving overly selfish. Thus, normative behavior is influenced by both seeking rewards and avoiding punishment. However, the neurochemical processes mediating the impact of these influences remain unknown. Several lines of evidence link the dopaminergic system to reward and punishment processing, respectively, but this evidence stems from studies in non-social contexts.

Objectives

The present study investigates dopaminergic drug effects on individuals' reward seeking and punishment avoidance in social interaction.

Methods

Two-hundred one healthy male participants were randomly assigned to receive 300 mg of l-3,4-dihydroxyphenylalanine (L-DOPA) or a placebo before playing an economic bargaining game. This game involved two conditions, one in which unfair behavior could be punished and one in which unfair behavior could not be punished.

Results

In the absence of punishment threats, L-DOPA administration led to more selfish behavior, likely mediated through an increase in reward seeking. In contrast, L-DOPA administration had no significant effect on behavior when faced with punishment threats.

Conclusions

The results of this study broaden the role of the dopaminergic system in reward seeking to human social interactions. We could show that even a single dose of a dopaminergic drug may bring selfish behavior to the fore, which in turn may shed new light on potential causal relationships between the dopaminergic system and norm abiding behaviors in certain clinical subpopulations.

Keywords

Dopamine Reward Punishment Normative behavior Decision making 

Notes

Acknowledgements

This project was supported by a grant to DK by the Swiss National Science Foundation (PP00P1_123381). CE acknowledges support of the Swiss National Science Foundation (PA00P1_134135).

Conflict of interest

The authors declare no conflict of interest.

References

  1. Bayer HM, Glimcher PW (2005) Midbrain dopamine neurons encode a quantitative reward prediction error signal. Neuron 47:129–41PubMedCentralPubMedCrossRefGoogle Scholar
  2. Bodi N, Keri S, Nagy H, Moustafa A, Myers CE, Daw N, Dibo G, Takats A, Bereczki D, Gluck MA (2009) Reward-learning and the novelty-seeking personality: a between- and within-subjects study of the effects of dopamine agonists on young Parkinson's patients. Brain 132:2385–95PubMedCrossRefGoogle Scholar
  3. Brischoux F, Chakraborty S, Brierley DI, Ungless MA (2009) Phasic excitation of dopamine neurons in ventral VTA by noxious stimuli. Proc Natl Acad Sci USA 106:4894–9PubMedCrossRefGoogle Scholar
  4. Buckholtz JW, Treadway MT, Cowan RL, Woodward ND, Benning SD, Li R, Ansari MS, Baldwin RM, Schwartzman AN, Shelby ES, Smith CE, Cole D, Kessler RM, Zald DH (2010) Mesolimbic dopamine reward system hypersensitivity in individuals with psychopathic traits. Nat Neurosci 13:419–421PubMedCentralPubMedCrossRefGoogle Scholar
  5. Carver CS, White TL (1994) Behavioral inhibition, behavioral activation, and affective responses to impending reward and punishment: The BIS/BAS Scales. J Pers Soc Psychol 67:319CrossRefGoogle Scholar
  6. Chamberlain SR, Muller U, Blackwell AD, Clark L, Robbins TW, Sahakian BJ (2006) Neurochemical modulation of response inhibition and probabilistic learning in humans. Science 311:861–3PubMedCentralPubMedCrossRefGoogle Scholar
  7. Dagher A, Robbins TW (2009) Personality, addiction, dopamine: insights from Parkinson's disease. Neuron 61:502–10PubMedCrossRefGoogle Scholar
  8. De Brita SA, Hodgins S (2009) Antisocial personality disorder. In: McMurran M, Howard R (eds) Personality, personality disorder and violence: an evidence based approach. Wiley, LondonGoogle Scholar
  9. Eisenegger C, Knoch D, Ebstein RP, Gianotti LR, Sandor PS, Fehr E (2010) Dopamine receptor D4 polymorphism predicts the effect of L-DOPA on gambling behavior. Biol Psychiat 67:702–6PubMedCrossRefGoogle Scholar
  10. Fehr E, Gächter S (2002) Altruistic punishment in humans. Nature 415:137–140PubMedCrossRefGoogle Scholar
  11. Fischbacher U (2007) z-Tree: Zurich toolbox for ready-made economic experiments. Exp Econ 10:171–178CrossRefGoogle Scholar
  12. Guitart-Masip M, Chowdhury R, Sharot T, Dayan P, Duzel E, Dolan RJ (2012) Action controls dopaminergic enhancement of reward representations. Proc Natl Acad Sci USA 109:7511–6PubMedCrossRefGoogle Scholar
  13. Gunter TD, Vaughn MG, Philibert RA (2010) Behavioral genetics in antisocial spectrum disorders and psychopathy: a review of the recent literature. Behav Sci Law 28:148–173PubMedCrossRefGoogle Scholar
  14. Güth W, Schmittberger R, Schwarze B (1982) An experimental analyses of ultimatium bargaining. J Econ Behav Organ 3:367–88CrossRefGoogle Scholar
  15. Haselhuhn MP, Mellers BA (2005) Emotions and cooperation in economic games. Brain Res Cogn Brain Res 23:24–33PubMedCrossRefGoogle Scholar
  16. Henrich J, Ensminger J, McElreath R, Barr A, Barrett C, Bolyanatz A, Cardenas JC, Gurven M, Gwako E, Henrich N, Lesorogol C, Marlowe F, Tracer D, Ziker J (2010) Markets, religion, community size, and the evolution of fairness and punishment. Science 327:1480–4PubMedCrossRefGoogle Scholar
  17. Heym N, Ferguson E, Lawrence C (2008) An evaluation of the relationship between Gray's revised RST and Eysenck's PEN: distinguishing BIS and FFFS in Carver and White's BIS/BAS scales. Pers Indiv Differ 45:709–715CrossRefGoogle Scholar
  18. Ikemoto S, Panksepp J (1999) The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking. Brain Res Brain Res Rev 31:6–41PubMedCrossRefGoogle Scholar
  19. Lammel S, Ion DI, Roeper J, Malenka RC (2011) Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli. Neuron 70:855–62PubMedCentralPubMedCrossRefGoogle Scholar
  20. Lammel S, Lim BK, Ran C, Huang KW, Betley MJ, Tye KM, Deisseroth K, Malenka RC (2012) Input-specific control of reward and aversion in the ventral tegmental area. Nature 491:212–7PubMedCentralPubMedCrossRefGoogle Scholar
  21. Leyton M, Boileau I, Benkelfat C, Diksic M, Baker G, Dagher A (2002) Amphetamine-induced increases in extracellular dopamine, drug wanting, and novelty seeking: a PET/[11C]raclopride study in healthy men. Neuropsychopharmacol 27:1027–35CrossRefGoogle Scholar
  22. Maia TV (2010) Two-factor theory, the actor-critic model, and conditioned avoidance. Learn Behav 38:50–67PubMedCrossRefGoogle Scholar
  23. Matsumoto M, Hikosaka O (2009) Two types of dopamine neuron distinctly convey positive and negative motivational signals. Nature 459:837–41PubMedCentralPubMedCrossRefGoogle Scholar
  24. Mirenowicz J, Schultz W (1996) Preferential activation of midbrain dopamine neurons by appetitive rather than aversive stimuli. Nature 379:449–51PubMedCrossRefGoogle Scholar
  25. Mowrer O (1947) On the dual nature of learning – a re-interpretation of "conditioning" and "problem-solving". Harv Educ Rev 17:102–148Google Scholar
  26. Norris H (1971) The action of sedatives on brain stem oculomotor systems in man. Neuropharmacol 10:181–91CrossRefGoogle Scholar
  27. O'Sullivan SS, Lees AJ (2011) Dopamine dysregulation syndrome Parkinson's disease. Blackwell, London, pp 202–214Google Scholar
  28. Pessiglione M, Seymour B, Flandin G, Dolan RJ, Frith CD (2006) Dopamine-dependent prediction errors underpin reward-seeking behaviour in humans. Nature 442:1042–5PubMedCentralPubMedCrossRefGoogle Scholar
  29. Raftery AE (1995) Bayesian model selection in social research. Sociol Methodol 25:111–164Google Scholar
  30. Robinson OJ, Standing HR, DeVito EE, Cools R, Sahakian BJ (2010) Dopamine precursor depletion improves punishment prediction during reversal learning in healthy females but not males. Psychopharmacology (Berlin) 211:187–95CrossRefGoogle Scholar
  31. Rogers RD (2011) The roles of dopamine and serotonin in decision making: evidence from pharmacological experiments in humans. Neuropsychopharmacol 36:114–32CrossRefGoogle Scholar
  32. Rouder JN, Speckman PL, Sun D, Morey RD, Iverson G (2009) Bayesian t tests for accepting and rejecting the null hypothesis. Psychon Bull Rev 16:225–237PubMedCrossRefGoogle Scholar
  33. Rounsaville BJ (2004) Treatment of cocaine dependence and depression. Biol Psychiat 56:803–9PubMedCrossRefGoogle Scholar
  34. Salamone JD (1994) The involvement of nucleus accumbens dopamine in appetitive and aversive motivation. Behav Brain Res 61:117–33PubMedCrossRefGoogle Scholar
  35. Scheres A, Sanfey AG (2006) Individual differences in decision making: Drive and reward responsiveness affect strategic bargaining in economic games. Behav Brain Funct 2:35PubMedCentralPubMedCrossRefGoogle Scholar
  36. Schultz W (2007) Multiple dopamine functions at different time courses. Annu Rev Neurosci 30:259–88PubMedCrossRefGoogle Scholar
  37. Sharot T, Shiner T, Brown AC, Fan J, Dolan RJ (2009) Dopamine enhances expectation of pleasure in humans. Curr Biol 19:2077–80PubMedCentralPubMedCrossRefGoogle Scholar
  38. Soderstrom H, Blennow K, Manhem A, Forsman A (2001) CSF studies in violent offenders - I. 5-HIAA as a negative and HVA as a positive predictor of psychopathy. J Neural Transm 108:869–878PubMedCrossRefGoogle Scholar
  39. Spitzer M, Fischbacher U, Herrnberger B, Gron G, Fehr E (2007) The neural signature of social norm compliance. Neuron 56:185–196PubMedCrossRefGoogle Scholar
  40. Ungless MA, Magill PJ, Bolam JP (2004) Uniform inhibition of dopamine neurons in the ventral tegmental area by aversive stimuli. Science 303:2040–2PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Institute of Psychology, Social and Affective NeuroscienceUniversity of BaselBaselSwitzerland
  2. 2.Department of Experimental Psychology, Behavioural and Clinical Neuroscience InstituteUniversity of CambridgeCambridgeUK
  3. 3.Department of EconomicsUniversity of KonstanzKonstanzGermany
  4. 4.Thurgau Institute of EconomicsKreuzlingenSwitzerland
  5. 5.Social and Affective Neuroscience, Department of PsychologyUniversity of BaselBaselSwitzerland

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