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Psychopharmacology

, Volume 230, Issue 3, pp 487–497 | Cite as

Effects of acute alcohol intoxication on saccadic conflict and error processing

  • Ksenija Marinkovic
  • Elizabeth Rickenbacher
  • Sheeva Azma
  • Elinor Artsy
  • Adrian K. C. Lee
Original Investigation

Abstract

Rationale

Flexible behavior optimization relies on cognitive control which includes the ability to suppress automatic responses interfering with relevant goals. Extensive evidence suggests that the anterior cingulate cortex (ACC) is the central node in a predominantly frontal cortical network subserving executive tasks. Neuroimaging studies indicate that the ACC is sensitive to acute intoxication during conflict, but such evidence is limited to tasks using manual responses with arbitrary response contingencies.

Objectives

The present study was designed to examine whether alcohol's effects on top–down cognitive control would generalize to the oculomotor system during inhibition of hardwired saccadic responses.

Methods

Healthy social drinkers (N = 22) underwent functional magnetic resonance imaging (fMRI) scanning and eye movement tracking during alcohol (0.6 g/kg ethanol for men, 0.55 g/kg for women) and placebo conditions in a counterbalanced design. They performed visually guided prosaccades (PS) towards a target and volitional antisaccades (AS) away from it. To mitigate possible vasoactive effects of alcohol on the BOLD (blood oxygenation level-dependent) signal, resting perfusion was quantified with arterial spin labeling (ASL) and used as a covariate in the BOLD analysis.

Results

Saccadic conflict was subserved by a distributed frontoparietal network. However, alcohol intoxication selectively attenuated activity only in the ACC to volitional AS and erroneous responses.

Conclusions

This study provides converging evidence for the selective ACC vulnerability to alcohol intoxication during conflict across different response modalities and executive tasks, confirming its supramodal, high-level role in cognitive control. Alcohol intoxication may impair top–down regulative functions by attenuating the ACC activity, resulting in behavioral disinhibition and decreased self-control.

Keywords

Anterior cingulate cortex Cognitive control Antisaccades Alcohol intoxication Error-related activity Arterial spin labeling (ASL) 

Notes

Acknowledgments

This work was supported by funds from the National Institutes of Health (R01-AA016624 and P41RR14075) and Medical Investigation of Neurodevelopmental Disorders (MIND) Institute. Data were collected at the MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging. Authors report no financial or other conflict of interest related to this work. We thank Simon Sigalovsky, Matija Zelic, Sarah Sheldon, Roya Bagheri, Lawrence Wald, and Dara Manoach for assistance.

Supplementary material

213_2013_3173_MOESM1_ESM.docx (84 kb)
ESM 1 (DOCX 83.6 KB)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Ksenija Marinkovic
    • 1
  • Elizabeth Rickenbacher
    • 2
  • Sheeva Azma
    • 3
  • Elinor Artsy
    • 4
  • Adrian K. C. Lee
    • 5
  1. 1.Department of RadiologyUniversity of California at San DiegoLa JollaUSA
  2. 2.Champalimaud Neuroscience ProgrammeChapmalimaud Center for the UnknownLisbonPortugal
  3. 3.Interdisciplinary Program in NeuroscienceGeorgetown UniversityWashingtonUSA
  4. 4.Department of NeurologyCedars-Sinai Medical GroupLos AngelesUSA
  5. 5.Department of Speech and Hearing Sciences and Institute for Learning and Brain SciencesUniversity of WashingtonSeattleUSA

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