Psychopharmacology

, Volume 229, Issue 4, pp 627–637

NMDA receptor antagonists distort visual grouping in rats performing a modified two-choice visual discrimination task

  • Katja Clarissa Ward
  • Halima Zainab Khattak
  • Louise Richardson
  • Jonathan Loon Choon Lee
  • Martin Vreugdenhil
Original Investigation

DOI: 10.1007/s00213-013-3123-8

Cite this article as:
Ward, K.C., Khattak, H.Z., Richardson, L. et al. Psychopharmacology (2013) 229: 627. doi:10.1007/s00213-013-3123-8

Abstract

Rationale

Visual perception is impaired during pathological psychosis, which can be mimicked by NMDA receptor antagonists. However, the underlying mechanisms are poorly understood, partly due to limits of current rodent models for visual integration.

Objectives

The objectives of the study are (1) to develop a rodent task that can differentiate between effects on perception and nonspecific effects on task performance and (2) to test whether NMDA receptor antagonists affect visual perception in rats.

Methods

We used an adaptation of Glass patterns to assess visual grouping in rats using a two-choice visual discrimination task in an infrared touch screen conditioning chamber. After rats learned to discriminate between a radial and a concentric bipole pattern, the ability to discriminate between these patterns was tested at various levels of distortion and a psychometric function was fit to obtain the maximum task performance and signal level needed for half-maximum performance.

Results

NMDA receptor antagonists ketamine and phencyclidine at low doses increased the signal quality needed to discriminate between the visual patterns, without affecting the ability to discriminate between undistorted images. At higher doses, the ability to perform the task even with undistorted images was impaired, which was associated with stereotypic behaviour and increased impulsivity.

Conclusions

The Glass pattern-based visual grouping task is able to differentiate the effect of psychotomimetic NMDA receptor antagonists on visual perception from the effects on motor and memory functions. The half-maximum performance signal level allows quantification of cognitive psychosis in rodents, which can be translated to human psychometric functions and can be used in the development of more effective treatments.

Keywords

Ketamine Phencyclidine Glass pattern Visual grouping Operant conditioning Stereotypic behaviour Psychometric function Touch screen 

Supplementary material

213_2013_3123_MOESM1_ESM.pdf (36 kb)
ESM 1(PDF 35 kb)
213_2013_3123_MOESM2_ESM.pdf (62 kb)
ESM 2(PDF 61 kb)
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ESM 3(PDF 994 kb)
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ESM 4(PDF 88 kb)
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ESM 5(PDF 39 kb)
213_2013_3123_MOESM6_ESM.pdf (138 kb)
ESM 6(PDF 138 kb)

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Katja Clarissa Ward
    • 1
  • Halima Zainab Khattak
    • 1
  • Louise Richardson
    • 1
  • Jonathan Loon Choon Lee
    • 2
  • Martin Vreugdenhil
    • 1
  1. 1.Neuronal Networks Group, School of Clinical and Experimental MedicineUniversity of BirminghamBirminghamUK
  2. 2.Psychobiology Group, School of PsychologyUniversity of BirminghamBirminghamUK

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