, Volume 225, Issue 3, pp 719–731 | Cite as

Simultaneous blockade of dopamine and noradrenaline reuptake promotes disadvantageous decision making in a rat gambling task

  • Petra J. J. Baarendse
  • Catharine A. Winstanley
  • Louk J. M. J. VanderschurenEmail author
Original Investigation



The inability to make profitable long-term decisions has been implicated in several psychiatric disorders. There is emerging evidence to support a role for dopamine (DA) in decision making, but our understanding of the role of noradrenaline (NA) and serotonin (5-HT) in decision making, and of possible interactions between the three monoamines, is limited. Moreover, impulsivity has been associated with aberrant decision making, but the underlying mechanisms are incompletely understood.


The purpose of this study is to improve our understanding of the neuropharmacological mechanisms of decision making and impulse control.


We investigated the effects of amphetamine (0.25–1.0 mg/kg) and selective reuptake inhibitors of DA (GBR12909; 2.5–10 mg/kg), NA (atomoxetine; 0.3–3.0 mg/kg), and 5-HT (citalopram; 0.3–3.0 mg/kg) in a rat gambling task (rGT). Since the rGT allows for detection of impulsive action, i.e., premature responding, we also assessed the relationship between decision making and impulsivity.


In the rGT, rats developed an optimal choice strategy from the first session onwards. Elevation of endogenous DA or NA levels increased and decreased impulsivity, respectively, but did not alter decision making. However, simultaneous blockade of DA and NA disrupted decision making, reflected by a relative decrease in choice for the advantageous choice options. Increasing 5-HT neurotransmission did not affect decision making or impulsivity.


These data suggest important but complementary or redundant roles of DA and NA neurotransmission in decision-making processes based on reward probability and punishment. Moreover, impulse control and decision making in the rGT rely on dissociable mechanisms.


Decision making Impulsivity Dopamine Serotonin Noradrenaline Rat gambling task 



This study was supported by the National Institute on Drug Abuse Grant R01 DA022628 (L.J.M.J.V.).


  1. Arnsten AFT (1997) Catecholamine regulation of the prefrontal cortex. J Psychopharmacol 11:151–162PubMedCrossRefGoogle Scholar
  2. Arnsten AFT (2000) Through the looking glass: differential noradrenergic modulation of prefrontal cortical function. Neural Plast 7:133–146PubMedCrossRefGoogle Scholar
  3. Aston-Jones G, Cohen JD (2005) An integrative theory of locus coeruleus–norepinephrine function: adaptive gain and optimal performance. Annu Rev Neurosci 28:403–450PubMedCrossRefGoogle Scholar
  4. Baarendse PJJ, Vanderschuren LJMJ (2012) Dissociable effects of monoamine reuptake inhibitors on distinct forms of impulsive behavior in rats. Psychopharmacology 219:313–326PubMedCrossRefGoogle Scholar
  5. Bark R, Dieckmann S, Bogerts B, Northoff G (2005) Deficit in decision making in catatonic schizophrenia: an exploratory study. Psychiatry Res 134:131–141PubMedCrossRefGoogle Scholar
  6. Bechara A, Damasio H (2002) Decision-making and addiction (part I): impaired activation of somatic states in substance dependent individuals when pondering decisions with negative future consequences. Neuropsychologia 40:1675–1689PubMedCrossRefGoogle Scholar
  7. Bechara A, Damasio AR, Damasio H, Anderson SW (1994) Insensitivity to future consequences following damage to human prefrontal cortex. Cognition 50:7–15PubMedCrossRefGoogle Scholar
  8. Bechara A, Dolan S, Denburg N, Hindes A, Anderson SW, Nathan PE (2001) Decision-making deficits, linked to a dysfunctional ventromedial prefrontal cortex, revealed in alcohol and stimulant abusers. Neuropsychologia 39:376–389PubMedCrossRefGoogle Scholar
  9. Berridge KC (2007) The debate over dopamine’s role in reward: the case for incentive salience. Psychopharmacology 191:391–431PubMedCrossRefGoogle Scholar
  10. Blondeau C, Dellu-Hagedorn F (2007) Dimensional analysis of ADHD subtypes in rats. Biol Psychiatry 61:1340–1350PubMedCrossRefGoogle Scholar
  11. Boureau Y-L, Dayan P (2010) Opponency revisited: competition and cooperation between dopamine and serotonin. Neuropsychopharmacology 36:74–97PubMedCrossRefGoogle Scholar
  12. Bouret S, Sara SJ (2005) Network reset: a simplified overarching theory of locus coeruleus noradrenaline function. Trends Neurosci 28:574–582PubMedCrossRefGoogle Scholar
  13. Brand M, Labudda K, Kalbe E, Hilker R, Emmans D, Fuchs G, Kessler J, Markowitsch HJ (2004) Decision-making impairments in patients with Parkinson’s disease. Behav Neurol 15:77–85PubMedGoogle Scholar
  14. Brand M, Kalbe E, Labudda K, Fujiwara E, Kessler J, Markowitsch HJ (2005) Decision-making impairments in patients with pathological gambling. Psychiatry Res 133:91–99PubMedCrossRefGoogle Scholar
  15. Brand M, Recknor EC, Grabenhorst F, Bechara A (2007) Decisions under ambiguity and decisions under risk: correlations with executive functions and comparisons of two different gambling tasks with implicit and explicit rules. J Clin Exp Neuropsychol 29:86–99PubMedCrossRefGoogle Scholar
  16. Cardinal RN, Robbins TW, Everitt BJ (2000) The effects of d-amphetamine, chlordiazepoxide, alpha-flupenthixol and behavioural manipulations on choice of signalled and unsignalled delayed reinforcement in rats. Psychopharmacology 152:362–375PubMedCrossRefGoogle Scholar
  17. Carli M, Robbins TW, Evenden JL, Everitt BJ (1983) Effects of lesions to ascending noradrenergic neurones on performance of a 5-choice serial reaction task in rats; implications for theories of dorsal noradrenergic bundle function based on selective attention and arousal. Behav Brain Res 9:361–380PubMedCrossRefGoogle Scholar
  18. Cavedini P, Riboldi G, Keller R, D’annucci A, Bellodi L (2002) Frontal lobe dysfunction in pathological gambling patients. Biol Psychiatry 51:334–341PubMedCrossRefGoogle Scholar
  19. Cole BJ, Robbins TW (1987) Amphetamine impairs the discriminative performance of rats with dorsal noradrenergic bundle lesions on a 5-choice serial reaction time task: new evidence for central dopaminergic–noradrenergic interactions. Psychopharmacology 91:458–466PubMedCrossRefGoogle Scholar
  20. Cole BJ, Robbins TW (1992) Forebrain norepinephrine: role in controlled information processing in the rat. Neuropsychopharmacology 7:129–142PubMedGoogle Scholar
  21. Cools R, Roberts AC, Robbins TW (2008) Serotoninergic regulation of emotional and behavioural control processes. Trends Cogn Sci 12:31–40PubMedCrossRefGoogle Scholar
  22. Cools R, Nakamura K, Daw ND (2011) Serotonin and dopamine: unifying affective, activational, and decision functions. Neuropsychopharmacology 36:98–113PubMedCrossRefGoogle Scholar
  23. Dalley JW, McGaughy J, O’Connell MT, Cardinal RN, Levita L, Robbins TW (2001) Distinct changes in cortical acetylcholine and noradrenaline efflux during contingent and noncontingent performance of a visual attentional task. J Neurosci 21:4908–4914PubMedGoogle Scholar
  24. Dalley JW, Cardinal RN, Robbins TW (2004) Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates. Neurosci Biobehav Rev 28:771–784PubMedCrossRefGoogle Scholar
  25. Dalley JW, Everitt BJ, Robbins TW (2011) Impulsivity, compulsivity, and top-down cognitive control. Neuron 69:680–694PubMedCrossRefGoogle Scholar
  26. Dayan P, Huys QJ (2008) Serotonin, inhibition, and negative mood. PLoS Comput Biol 4:e4PubMedCrossRefGoogle Scholar
  27. Denk F, Walton ME, Jennings KA, Sharp T, Rushworth MFS, Bannerman DM (2005) Differential involvement of serotonin and dopamine systems in cost–benefit decisions about delay or effort. Psychopharmacology 179:587–596PubMedCrossRefGoogle Scholar
  28. Eagle DM, Baunez C (2010) Is there an inhibitory-response-control system in the rat? Evidence from anatomical and pharmacological studies of behavioral inhibition. Neurosci Biobehav Rev 34:50–72PubMedCrossRefGoogle Scholar
  29. Ernst M, Paulus MP (2005) Neurobiology of decision making: a selective review from a neurocognitive and clinical perspective. Biol Psychiatry 58:597–604PubMedCrossRefGoogle Scholar
  30. Ernst M, Grant SJ, London ED, Contoreggi CS, Kimes AS, Spurgeon L (2003) Decision making in adolescents with behavior disorders and adults with substance abuse. Am J Psychiatry 160:33–40PubMedCrossRefGoogle Scholar
  31. Evenden JL (1999) Varieties of impulsivity. Psychopharmacology 146:348–361PubMedCrossRefGoogle Scholar
  32. Fernando AB, Economidou D, Theobald DE, Zou MF, Newman AH, Spoelder M, Caprioli D, Moreno M, Hipόlito L, Aspinall AT, Robbins TW, Dalley JW (2012) Modulation of high impulsivity and attentional performance in rats by selective direct and indirect dopaminergic and noradrenergic receptor agonists. Psychopharmacology 219:341–352PubMedCrossRefGoogle Scholar
  33. Floresco SB, Jentsch JD (2011) Pharmacological enhancement of memory and executive functioning in laboratory animals. Neuropsychopharmacology 36:227–250PubMedCrossRefGoogle Scholar
  34. Floresco SB, Magyar O (2006) Mesocortical dopamine modulation of executive functions: beyond working memory. Psychopharmacology 188:567–585PubMedCrossRefGoogle Scholar
  35. Floresco SB, Tse MT, Ghods-Sharifi S (2008a) Dopaminergic and glutamatergic regulation of effort- and delay-based decision making. Neuropsychopharmacology 33:1966–1979PubMedCrossRefGoogle Scholar
  36. Floresco SB, St. Onge JR, Ghods-Sharifi S, Winstanley CA (2008b) Cortico-limbic-striatal circuits subserving different forms of cost–benefit decision making. Cogn Affect Behav Neurosci 8:375–389PubMedCrossRefGoogle Scholar
  37. Franken IH, Muris P (2005) Individual differences in decision making. Personal Individ Differ 39:991–998CrossRefGoogle Scholar
  38. Franken IH, van Strien JW, Nijs I, Muris P (2008) Impulsivity is associated with behavioral decision-making deficits. Psychiatry Res 158:155–163PubMedCrossRefGoogle Scholar
  39. Gallagher DA, O’Sullivan SS, Evans AH, Lees AJ, Schrag A (2007) Pathological gambling in Parkinson’s disease: risk factors and differences from dopamine dysregulation. An analysis of published case series. Mov Disord 22:1757–1763PubMedCrossRefGoogle Scholar
  40. Garon N, Moore C, Waschbusch DA (2006) Decision making in children with ADHD only, ADHD- anxious/depressed, and control children using a child version of the Iowa gambling task. J Atten Disord 9:607–619PubMedCrossRefGoogle Scholar
  41. Grant JE, Potenza MN (2007) Treatments for pathological gambling and other impulse control disorders. In: Nathan P, Gorman J (eds) A guide to treatments that work. Oxford University Press, Oxford, pp 561–579Google Scholar
  42. Hanson KL, Luciana M, Sullwold K (2008) Reward-related decision-making deficits and elevated impulsivity among MDMA and other drug users. Drug Alcohol Depend 96:99–110PubMedCrossRefGoogle Scholar
  43. Hollander E, Rosen J (2000) Impulsivity. J Psychopharmacol 14:S39–S44PubMedGoogle Scholar
  44. Johnson SA, Yechiam E, Murphy RR, Queller S, Stout JC (2006) Motivational processes and autonomic responsivity in Asperger’s disorder: evidence from the Iowa Gambling Task. J Int Neuropsychol Soc 12:668–676PubMedGoogle Scholar
  45. Jollant F, Bellivier F, Leboyer M, Astruc B, Torres S, Verdier R, Castelnau D, Malafosse A, Courtet P (2005) Impaired decision making in suicide attempters. Am J Psychiatry 162:304–310PubMedCrossRefGoogle Scholar
  46. Kranz GS, Kasper S, Lanzenberger R (2010) Reward and the serotonergic system. Neuroscience 166:1023–1035PubMedCrossRefGoogle Scholar
  47. Kreek MJ, Nielsen DA, Butelman ER, LaForge KS (2005) Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction. Nat Neurosci 8:1450–1457PubMedCrossRefGoogle Scholar
  48. Lawrence NS, Wooderson S, Mataix-Cols D, David R, Speckens A, Phillips ML (2006) Decision making and set shifting impairments are associated with distinct symptom dimensions in obsessive–compulsive disorder. Neuropsychology 20:409–419PubMedCrossRefGoogle Scholar
  49. Luman M, Oosterlaan J, Knol DL, Sergeant JA (2008) Decision-making in ADHD: sensitive to frequency but blind to the magnitude of penalty? J Child Psychol Psychiatry 49:712–722PubMedCrossRefGoogle Scholar
  50. Malloy-Diniz L, Fuentes D, Leite WB, Correa H, Bechara A (2007) Impulsive behavior in adults with attention deficit/hyperactivity disorder: characterization of attentional, motor and cognitive impulsiveness. J Int Neuropsychol Soc 13:693–698PubMedCrossRefGoogle Scholar
  51. Mavaddat N, Kirkpatrick PJ, Rogers RD, Sahakian BJ (2000) Deficits in decision-making in patients with aneurysms of the anterior communicating artery. Brain 123:2109–2117PubMedCrossRefGoogle Scholar
  52. McDonald J (2009) Handbook of biological statistics, 2nd edn. Sparky House Publishing, BaltimoreGoogle Scholar
  53. Mitchell MR, Vokes CM, Blankenship AL, Simon NW, Setlow B (2011) Effects of acute administration of nicotine, amphetamine, diazepam, morphine, and ethanol on risky decision-making in rats. Psychopharmacology 218:703–712PubMedCrossRefGoogle Scholar
  54. Morgan MJ, Impallomeni LC, Pirona A, Rogers RD (2006) Elevated impulsivity and impaired decision-making in abstinent ecstasy (MDMA) users compared to polydrug and drug-naïve controls. Neuropsychopharmacology 31:1562–1573PubMedCrossRefGoogle Scholar
  55. Navarra R, Graf R, Huang Y, Logue S, Comery T, Hughes Z, Day M (2008) Effects of atomoxetine and methylphenidate on attention and impulsivity in the 5-choice serial reaction time test. Prog Neuropsychopharmacol Biol Psychiatry 32:34–41PubMedCrossRefGoogle Scholar
  56. O’Carroll RE, Papps BP (2003) Decision making in humans: the effect of manipulating the central noradrenergic system. J Neurol Neurosurg Psychiatry 74:376–378PubMedCrossRefGoogle Scholar
  57. O’Donnell JM, Marek GJ, Seiden LS (2005) Antidepressant effects assessed using behavior maintained under a differential-reinforcement-of-low-rate (DRL) operant schedule. Neurosci Biobehav Rev 29:785–798PubMedCrossRefGoogle Scholar
  58. Ouyang M, Young MB, Lestini MM, Schutsky K, Thomas SA (2012) Redundant catecholamine signaling consolidates fear memory via phospholipase C. J Neurosci 32:1932–1941PubMedCrossRefGoogle Scholar
  59. Paine TA, Tomasiewicz HC, Zhang K, Carlezon WA (2007) Sensitivity of the five-choice serial reaction time task to the effects of various psychotropic drugs in Sprague–Dawley rats. Biol Psychiatry 62:687–693PubMedCrossRefGoogle Scholar
  60. Paterson NE, Ricciardi J, Wetzler C, Hanania T (2011) Sub-optimal performance in the 5-choice serial reaction time task in rats was sensitive to methylphenidate, atomoxetine and D-amphetamine, but unaffected by the COMT inhibitor tolcapone. Neurosci Res 69:41–50PubMedCrossRefGoogle Scholar
  61. Pattij T, Vanderschuren LJ (2008) The neuropharmacology of impulsive behaviour. Trends Pharmacol Sci 29:192–199PubMedCrossRefGoogle Scholar
  62. Raylu N, Oei TP (2002) Pathological gambling. A comprehensive review. Clin Psychol Rev 22:1009–1061PubMedCrossRefGoogle Scholar
  63. Robbins TW (2002) The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry. Psychopharmacology 163:362–380PubMedCrossRefGoogle Scholar
  64. Robbins TW, Arnsten AF (2009) The neuropsychopharmacology of fronto-executive function: monoaminergic modulation. Annu Rev Neurosci 32:267–287PubMedCrossRefGoogle Scholar
  65. Robbins TW, Everitt BJ (2007) A role for mesencephalic dopamine in activation: commentary on Berridge (2006). Psychopharmacology 191:433–437PubMedCrossRefGoogle Scholar
  66. Robinson ES, Eagle DM, Mar AC, Bari A, Banerjee G, Jiang X, Dalley JW, Robbins TW (2008) Similar effects of the selective noradrenaline reuptake inhibitor atomoxetine on three distinct forms of impulsivity in the rat. Neuropsychopharmacology 33:1028–1037PubMedCrossRefGoogle Scholar
  67. Rogers RD (2011) The roles of dopamine and serotonin in decision making: evidence from pharmacological experiments in humans. Neuropsychopharmacology 36:114–132PubMedCrossRefGoogle Scholar
  68. Rogers RD, Robbins TW (2001) Investigating the neurocognitive deficits associated with chronic drug misuse. Curr Opin Neurobiol 11:250–257PubMedCrossRefGoogle Scholar
  69. Salamone JD, Cousins MS, Bucher S (1994) Anhedonia or anergia? Effects of haloperidol and nucleus accumbens dopamine depletion on instrumental response selection in a T-maze cost/benefit procedure. Behav Brain Res 65:221–229PubMedCrossRefGoogle Scholar
  70. Salamone JD, Correa M, Farrar A, Mingote SM (2007) Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits. Psychopharmacology 191:461–482PubMedCrossRefGoogle Scholar
  71. Schutter DJ, van Bokhoven I, Vanderschuren LJ, Lochman JE, Matthys W (2011) Risky decision making in substance dependent adolescents with a disruptive behavior disorder. J Abnorm Child Psychol 39:333–339PubMedCrossRefGoogle Scholar
  72. Seedat S, Kesler S, Niehaus DJ, Stein DJ (2000) Pathological gambling behaviour: emergence secondary to treatment of Parkinson’s disease with dopaminergic agents. Depress Anxiety 11:185–186PubMedCrossRefGoogle Scholar
  73. Sevy S, Hassoun Y, Bechara A, Yechiam E, Napolitano B, Burdick K, Delman H, Malhotra A (2006) Emotion-based decision-making in healthy subjects: short-term effects of reducing dopamine levels. Psychopharmacology 188:228–235PubMedCrossRefGoogle Scholar
  74. Shurman B, Horan WP, Nuechterlein KH (2005) Schizophrenia patients demonstrate a distinctive pattern of decision-making impairment on the Iowa Gambling Task. Schizophr Res 72:215–224PubMedCrossRefGoogle Scholar
  75. Simon NW, Gilbert RJ, Mayse JD, Bizon JL, Setlow B (2009) Balancing risk and reward: a rat model of risky decision making. Neuropsychopharmacology 34:2208–2217PubMedCrossRefGoogle Scholar
  76. Simon NW, Montgomery KS, Beas BS, Mitchell MR, LaSarge CL, Mendez IA, Bañuelos C, Vokes CM, Taylor AB, Haberman RP, Bizon JL, Setlow B (2011) Dopaminergic modulation of risky decision-making. J Neurosci 31:17460–17470PubMedCrossRefGoogle Scholar
  77. Sirviö J, Jäkälä P, Mazurkiewicz M, Haapalinna A, Riekkinen P Jr, Riekkinen PJ (1993) Dose- and parameter-dependent effects of atipamezole, an alpha 2-antagonist, on the performance of rats in a five-choice serial reaction time task. Pharmacol Biochem Behav 45:123–129PubMedCrossRefGoogle Scholar
  78. St Onge JR, Floresco SB (2009) Dopaminergic regulation of risk based decision-making. Neuropsychopharmacology 34:681–697PubMedCrossRefGoogle Scholar
  79. Sun H, Cocker PJ, Zeeb FD, Winstanley CA (2012) Chronic atomoxetine treatment during adolescence decreases impulsive choice, but not impulsive action, in adult rats and alters markers of synaptic plasticity in the orbitofrontal cortex. Psychopharmacology 219:285–301PubMedCrossRefGoogle Scholar
  80. Tops M, Russo S, Boksem MA, Tucker DM (2009) Serotonin: modulator of a drive to withdraw. Brain Cogn 71:427–436PubMedCrossRefGoogle Scholar
  81. Usher M, Cohen JD, Servan-Schreiber D, Rajkowski J, Aston-Jones G (1999) The role of locus coeruleus in the regulation of cognitive performance. Science 283:549–554PubMedCrossRefGoogle Scholar
  82. Van den Brink W (2012) Evidence-based pharmacological treatment of substance use disorders and pathological gambling. Curr Drug Abuse Rev 5:3–31PubMedCrossRefGoogle Scholar
  83. Van der Plas EA, Crone EA, van den Wildenberg WP, Tranel D, Bechara A (2009) Executive control deficits in substance-dependent individuals: a comparison of alcohol, cocaine, and methamphetamine and of men and women. J Clin Exp Neuropsychol 31:706–719PubMedCrossRefGoogle Scholar
  84. Van Gaalen MM, Brueggeman RJ, Bronius PFC, Schoffelmeer ANM, Vanderschuren LJMJ (2006a) Behavioral disinhibition requires dopamine receptor activation. Psychopharmacology 187:73–85PubMedCrossRefGoogle Scholar
  85. Van Gaalen MM, van Koten R, Schoffelmeer ANM, Vanderschuren LJMJ (2006b) Critical involvement of dopaminergic neurotransmission in impulsive decision making. Biol Psychiatry 60:66–73PubMedCrossRefGoogle Scholar
  86. Verdejo-García A, Rivas-Pérez C, Vilar-López R, Pérez-García M (2007) Strategic self-regulation, decision-making and emotion processing in poly-substance abusers in their first year of abstinence. Drug Alcohol Depend 86:139–146PubMedCrossRefGoogle Scholar
  87. Weintraub D, Siderowf AD, Potenza MN, Goveas J, Morales KH, Duda JE et al (2006) Association of dopamine agonist use with impulse control disorders in Parkinson disease. Arch Neurol 63:969–973PubMedCrossRefGoogle Scholar
  88. Winstanley CA (2011) The utility of rat models of impulsivity in developing pharmacotherapies for impulse control disorders. Br J Pharmacol 164:1301–1321PubMedCrossRefGoogle Scholar
  89. Zahrt J, Taylor JR, Mathew RG, Arnsten AF (1997) Supranormal stimulation of D1 dopamine receptors in the rodent prefrontal cortex impairs spatial working memory performance. J Neurosci 17:8528–8535PubMedGoogle Scholar
  90. Zeeb FD, Winstanley CA (2011) Lesions of the basolateral amygdala and orbitofrontal cortex differentially affect acquisition and performance of a rodent gambling task. J Neurosci 31:2197–2204PubMedCrossRefGoogle Scholar
  91. Zeeb FD, Robbins TW, Winstanley CA (2009) Serotonergic and dopaminergic modulation of gambling behavior as assessed using a novel rat gambling task. Neuropsychopharmacology 34:2329–2343PubMedCrossRefGoogle Scholar
  92. Zermatten AM, Van der Linden MP, d’Acremont MM, Jermann FM, Bechara AP (2005) Impulsivity and decision making. J Nerv Ment Dis 193:647–650PubMedCrossRefGoogle Scholar
  93. Zhang XL, Wang GB, Zhao LY, Sun LL, Wang J, Wu P, Lu L, Shi J (2012) Clonidine improved laboratory-measured decision-making performance in abstinent heroin addicts. PLoS One 7:e29084PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Petra J. J. Baarendse
    • 1
  • Catharine A. Winstanley
    • 3
  • Louk J. M. J. Vanderschuren
    • 1
    • 2
    Email author
  1. 1.Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of NeuroscienceUniversity Medical Center UtrechtUtrechtThe Netherlands
  2. 2.Department of Animals in Science and Society, Division of Behavioural Neuroscience, Faculty of Veterinary MedicineUtrecht UniversityUtrechtThe Netherlands
  3. 3.Department of PsychologyUniversity of British ColumbiaVancouverCanada

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