Sulpiride and refractory panic disorder
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The use of antipsychotics in patients with anxiety in recent years has increased, with a recent study showing that over a 12-year period, antipsychotic prescriptions in visits for anxiety disorders increased from 10.6 to 21.3 %, with the biggest increase among panic disorder (PD) patients (from 8 to 21.3 %) (Comer et al. 2011). Reasons for this remain unclear, but possible explanations include changes in patient characteristics, including increasing severity of illnesses among outpatient clients; greater prevalence or recognition of comorbidities (Comer et al. 2011); greater physician emphasis on symptom reduction, with increased acceptance of off-label antipsychotic prescriptions; a possible extrapolation to anxiety subjects by psychiatrists from their clinical experience of treating depressed patients with antipsychotics (Berman et al. 2009); and the availability of new antipsychotics with better side effect profiles, leading to a trend of changing from typical to...
KeywordsAnxiety Disorder Panic Disorder Panic Disorder Sulpiride Amisulpride
The grant for this trial was provided by the Brazilian Council for Scientific and Technological Development (CNPq) and the National Institute for Translational Medicine (INCT-TM). Drs. Nardi, Hallak, and Crippa are recipients of CNPq productivity fellowship awards. The authors declare that they have full control of all primary data and that they agree to allow the journal to review the data if requested.
Conflict of interest
The authors also declare that they have no conflict of interest.