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Psychopharmacology

, Volume 225, Issue 1, pp 75–93 | Cite as

Behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats

  • Tomáš Páleníček
  • Michaela Fujáková
  • Martin Brunovský
  • Jiří Horáček
  • Ingmar Gorman
  • Marie Balíková
  • Lukáš Rambousek
  • Kamila Syslová
  • Petr Kačer
  • Petr Zach
  • Věra Bubeníková-Valešová
  • Filip Tylš
  • Anna Kubešová
  • Jana Puskarčíková
  • Cyril Höschl
Original Investigation

Abstract

Rationale and objectives

Behavioral, neurochemical and pharmaco-EEG profiles of a new synthetic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats were examined.

Materials and methods

Locomotor effects, prepulse inhibition (PPI) of acoustic startle reaction (ASR), dopamine and its metabolite levels in nucleus accumbens (NAc), EEG power spectra and coherence in freely moving rats were analysed. Amphetamine was used as a reference compound.

Results

2C-B had a biphasic effect on locomotion with initial inhibitory followed by excitatory effect; amphetamine induced only hyperlocomotion. Both drugs induced deficits in the PPI; however they had opposite effects on ASR. 2C-B increased dopamine but decreased 3,4-dihydroxyphenylacetic acid (DOPAC) in the NAc. Low doses of 2C-B induced a decrease in EEG power spectra and coherence. On the contrary, high dose of 2C-B 50 mg/kg had a temporally biphasic effect with an initial decrease followed by an increase in EEG power; decrease as well as increase in EEG coherence was observed. Amphetamine mainly induced an increase in EEG power and coherence in theta and alpha bands. Increases in the theta and alpha power and coherence in 2C-B and amphetamine were temporally linked to an increase in locomotor activity and DA levels in NAc.

Conclusions

2C-B is a centrally active compound similar to other hallucinogens, entactogens and stimulants. Increased dopamine and decreased DOPAC in the NAc may reflect its psychotomimetic and addictive potential and monoaminoxidase inhibition. Alterations in brain functional connectivity reflected the behavioral and neurochemical changes produced by the drug; a correlation between EEG changes and locomotor behavior was observed.

Keywords

4-Bromo-2,5-dimethoxyphenethylamine (2C-B) Amphetamine Serotonin Dopamine Nucleus accumbens Behavior Microdialysis EEG power spectra EEG coherence Rats 

Notes

Acknowledgements

This study was supported by the grants IGA MHCR NS 10374, NS 10375, NT 13897, MEYSCR 1M0517, MHCR MZ0PCP2005, MICR VG20122015075 and VG20122015080. We thank Craig Hampson BSc (Hons) for his helpful comments and language correction.

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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Tomáš Páleníček
    • 1
  • Michaela Fujáková
    • 1
    • 5
  • Martin Brunovský
    • 1
  • Jiří Horáček
    • 1
  • Ingmar Gorman
    • 1
  • Marie Balíková
    • 2
  • Lukáš Rambousek
    • 3
    • 4
  • Kamila Syslová
    • 3
  • Petr Kačer
    • 3
  • Petr Zach
    • 5
  • Věra Bubeníková-Valešová
    • 1
  • Filip Tylš
    • 1
    • 5
  • Anna Kubešová
    • 1
    • 5
  • Jana Puskarčíková
    • 1
    • 5
  • Cyril Höschl
    • 1
  1. 1.Prague Psychiatric CenterBohniceCzech Republic
  2. 2.Institute of Forensic Medicine and Toxicology, 1st Faculty of MedicineCharles University in PraguePrague 2Czech Republic
  3. 3.Institute of Chemical TechnologyPrague 6Czech Republic
  4. 4.Institute of PhysiologyAcademy of Sciences of the Czech RepublicPrague 4Czech Republic
  5. 5.3rd Faculty of MedicineCharles University in PraguePrague 10Czech Republic

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